INT88705

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Context Info
Confidence 0.22
First Reported 2000
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 2.07
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ece1) peptidase activity (Ece1) Golgi apparatus (Ece1)
plasma membrane (Ece1)
Anatomy Link Frequency
blood 1
Ece1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 200 87.36 High High
Hippocampus 5 51.20 Quite High
Neuropeptide 11 25.00 Low Low
Inflammation 6 25.00 Low Low
Pain 1 25.00 Low Low
Cholecystokinin 5 5.32 Low Low
cytokine 5 5.00 Very Low Very Low Very Low
Enkephalin 5 5.00 Very Low Very Low Very Low
Glutamate 5 5.00 Very Low Very Low Very Low
bradykinin 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypophosphatemia 1 100.00 Very High Very High Very High
Disease 206 75.00 Quite High
Targeted Disruption 80 52.72 Quite High
Alzheimer's Dementia 45 50.00 Quite Low
Amyloid Plaque 15 45.80 Quite Low
Cognitive Disorder 20 40.76 Quite Low
Toxicity 10 5.00 Very Low Very Low Very Low
Necrosis 10 5.00 Very Low Very Low Very Low
Adhesions 10 5.00 Very Low Very Low Very Low
Cancer 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Four alternative splice variants of ECE-1, localized both at the cell membrane and intracellularly, have been reported in humans (ECE-1a, ECE-1b, ECE-1c, and ECE-1d) [116, 117].
Localization (localized) of ECE-1a
1) Confidence 0.22 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.39 Pain Relevance 0.11
Four alternative splice variants of ECE-1, localized both at the cell membrane and intracellularly, have been reported in humans (ECE-1a, ECE-1b, ECE-1c, and ECE-1d) [116, 117].
Localization (localized) of ECE-1b
2) Confidence 0.22 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.39 Pain Relevance 0.11
Four alternative splice variants of ECE-1, localized both at the cell membrane and intracellularly, have been reported in humans (ECE-1a, ECE-1b, ECE-1c, and ECE-1d) [116, 117].
Localization (localized) of ECE-1
3) Confidence 0.22 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.34 Pain Relevance 0.11
The mammalian neprilysin (NEP) family comprises at least seven members: NEP itself, Kell blood group antigen (KELL), the endothelin-converting enzymes (ECE-1 and ECE-2), the enzyme PEX, associated with X-linked hypophosphataemia, "X-converting enzyme" (XCE) a CNS-expressed orphan peptidase and a soluble, secreted endopeptidase (SEP).
Localization (secreted) of ECE-1 in blood associated with hypophosphatemia
4) Confidence 0.13 Published 2000 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10849750 Disease Relevance 0.17 Pain Relevance 0
Four alternative splice variants of ECE-1, localized both at the cell membrane and intracellularly, have been reported in humans (ECE-1a, ECE-1b, ECE-1c, and ECE-1d) [116, 117].
Localization (localized) of ECE-1d
5) Confidence 0.10 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.39 Pain Relevance 0.11
Four alternative splice variants of ECE-1, localized both at the cell membrane and intracellularly, have been reported in humans (ECE-1a, ECE-1b, ECE-1c, and ECE-1d) [116, 117].
Localization (localized) of ECE-1c
6) Confidence 0.10 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.39 Pain Relevance 0.11

General Comments

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