INT88721

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.16
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HPRT1) small molecule metabolic process (HPRT1) transferase activity, transferring glycosyl groups (HPRT1)
cytoplasm (HPRT1)
Anatomy Link Frequency
muscle 2
HPRT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 30 95.92 Very High Very High Very High
cytokine 9 94.88 High High
anesthesia 3 69.12 Quite High
imagery 2 11.88 Low Low
cINOD 10 5.00 Very Low Very Low Very Low
COX-2 inhibitor 8 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 4 98.88 Very High Very High Very High
Necrosis 1 97.44 Very High Very High Very High
Cancer 80 97.08 Very High Very High Very High
Familial Dysautonomia 121 96.80 Very High Very High Very High
INFLAMMATION 32 95.92 Very High Very High Very High
Lung Injury 8 91.44 High High
Hyperinsulinism 1 87.92 High High
Esophageal Cancer 14 85.20 High High
Cytomegalovirus Infection 1 83.20 Quite High
Congenital Anomalies 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(Vandesompele et al., 2002) At least three out of the following four housekeeping genes were used for each experiment: glyceraldehyde-3 phosphate dehydrogenase (GAPDH), hypoxanthine phosphoribosyltransferase 1 (HPRT1), human porphobilinogen deaminase (PBGD) and TATA box binding protein (TBP).
Positive_regulation (experiment) of Gene_expression (used) of hypoxanthine phosphoribosyltransferase 1
1) Confidence 0.49 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1481577 Disease Relevance 0.28 Pain Relevance 0
(Vandesompele et al., 2002) At least three out of the following four housekeeping genes were used for each experiment: glyceraldehyde-3 phosphate dehydrogenase (GAPDH), hypoxanthine phosphoribosyltransferase 1 (HPRT1), human porphobilinogen deaminase (PBGD) and TATA box binding protein (TBP).
Positive_regulation (experiment) of Gene_expression (used) of HPRT1
2) Confidence 0.49 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1481577 Disease Relevance 0.28 Pain Relevance 0
For normalization of the data the average of the expression level of four house-keeping genes, GAPDH, HPRT, beta-actin and beta-tubulin, was used.



Positive_regulation (used) of Gene_expression (expression) of HPRT
3) Confidence 0.49 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0 Pain Relevance 0
mRNA and hypoxanthine phosphoribosyltransferase (HPRT) mRNA expression was quantified using QRTPCR.
Positive_regulation (quantified) of Gene_expression (expression) of HPRT
4) Confidence 0.49 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2873469 Disease Relevance 0.48 Pain Relevance 0.14
Here we show that infection of human 1306, HPRT-negative cells with RAd-HPRT, expressed high enough levels of HPRT enzyme activity, as to reverse their abnormal biochemical phenotype, thus enhancing hypoxanthine incorporation and restoring purine recycling, increasing GTP levels, decreasing adenine incorporation, and allowing cell survival in HAT medium in which only cells expressing high levels of HPRT can survive.
Positive_regulation (levels) of Gene_expression (expressing) of HPRT associated with infection
5) Confidence 0.47 Published 1999 Journal Metab Brain Dis Section Abstract Doc Link 10850548 Disease Relevance 0.49 Pain Relevance 0.07
The HPRT1 transcript was selected as the reference gene on an empirical basis—HPRT1 expression in these men (1863±111 arbitrary units, mean±SEM) and women (1881±138 arbitrary units) was similar according to the microarray data (this choice does not necessarily mean that HPRT1 expression always is constant in muscle).
Positive_regulation (selected) of Gene_expression (expression) of HPRT1 in muscle
6) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.09 Pain Relevance 0
Since gene expression quantification using RT-qPCR requires a steady reference gene, we selected three genes frequently used for normalization of the data, ABL1, RPLP0, and HPRT1.
Positive_regulation (requires) of Gene_expression (expression) of HPRT1
7) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.54 Pain Relevance 0

General Comments

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