INT88724

Context Info Confidence 0.27 First Reported 1999 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.04 Pain Relevance 0.09

cytosol (HPRT1) small molecule metabolic process (HPRT1) transferase activity, transferring glycosyl groups (HPRT1) cytoplasm (HPRT1)

HPRT1 (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 1 89.80 Inflammatory response 1 28.52 Lasting pain 1 5.00 fibrosis 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Cytomegalovirus Infection 2 98.16 Cold Sores 18 97.42 Infection 3 90.16 Epstein-barr Virus 6 83.92 Syndrome 1 80.16 Congenital Anomalies 1 75.00 Herpes Simplex Virus 4 59.68 Factor Viii Deficiency 8 45.84 Neurological Disease 1 42.96 Coagulation Disorder 2 41.60

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We have constructed an adenoviral vector expressing the human HPRT cDNA under the transcriptional control of a short human cytomegalovirus major immediate early promoter (RAd-HPRT).

Regulation (under) of Gene_expression (expressing) of HPRT cDNA associated with cytomegalovirus infection

1) Confidence 0.27 Published 1999 Journal Metab Brain Dis Section Abstract Doc Link 10850548 Disease Relevance 0.40 Pain Relevance 0.09

Thus, HSV-1 HAC amplicons containing alphoid DNA for episomal maintenance and a HPRT minigene have efficiently transduced cultured cells, producing stable HPRT expression for over three months.

Regulation (producing) of Gene_expression (expression) of HPRT associated with cold sores

2) Confidence 0.21 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.64 Pain Relevance 0

General Comments

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