INT88725

Context Info Confidence 0.62 First Reported 1999 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 5 Total Number 7 Disease Relevance 1.28 Pain Relevance 0.24

cytosol (HPRT1) small molecule metabolic process (HPRT1) transferase activity, transferring glycosyl groups (HPRT1) cytoplasm (HPRT1)

Anatomy Link Frequency blood 1 chondrocytes 1 skeletal muscle 1 brain 1 HPRT1 (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 4 87.52 Dopamine 3 81.68 cerebral cortex 2 66.92 Neuropathic pain 36 50.00 Calcitonin gene-related peptide 2 15.20 Neuropeptide 2 13.92 withdrawal 14 5.00 cytokine 11 5.00 Eae 10 5.00 Osteoarthritis 9 5.00

Disease Link Frequency Relevance Heat Cytomegalovirus Infection 1 100.00 Infection 3 98.32 Sprains And Strains 2 93.76 Neurodegenerative Disease 10 82.48 Syndrome 1 77.88 Targeted Disruption 28 77.16 Disease 42 75.00 Congenital Anomalies 3 75.00 Neuropathic Pain 38 50.00 Repression 2 13.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We have constructed an adenoviral vector expressing the human HPRT cDNA under the transcriptional control of a short human cytomegalovirus major immediate early promoter (RAd-HPRT).

Regulation (control) of RAd-HPRT associated with cytomegalovirus infection

1) Confidence 0.62 Published 1999 Journal Metab Brain Dis Section Abstract Doc Link 10850548 Disease Relevance 0.42 Pain Relevance 0.09

In our study we have examined the effect of HPRT deficiency on the differentiation of neurons in hNSCs isolated from human LND fetal brain.

Spec (examined) Regulation (effect) of HPRT in brain

2) Confidence 0.45 Published 2010 Journal Hum. Mol. Genet. Section Abstract Doc Link 20159777 Disease Relevance 0.13 Pain Relevance 0.12

For diacerein-treated chondrocytes, GAPDH, B2M, HPRT1 and SDHA were not significantly affected by any culture condition used.

Neg (not) Regulation (affected) of HPRT1 in chondrocytes

3) Confidence 0.29 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1820791 Disease Relevance 0 Pain Relevance 0

RtTA was targeted into the ubiquitously expressed Rosa26 locus, or Sox10 locus, and Runx1a-IRES-EGFP cDNA driven by the tetracycline-responsive element (TRE) targeted upstream the hypoxanthine phosphoribosyltransferase (HPRT) locus.

Regulation (targeted) of hypoxanthine phosphoribosyltransferase

4) Confidence 0.26 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.29 Pain Relevance 0

RtTA was targeted into the ubiquitously expressed Rosa26 locus, or Sox10 locus, and Runx1a-IRES-EGFP cDNA driven by the tetracycline-responsive element (TRE) targeted upstream the hypoxanthine phosphoribosyltransferase (HPRT) locus.

Regulation (targeted) of HPRT

5) Confidence 0.26 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.29 Pain Relevance 0

As shown, the M values of GNB2L1, HPRT1, and YWHAZ were lower than 0.5; therefore, these genes were concluded to be stably expressed reference genes in human skeletal muscle.

Regulation (values) of HPRT1 in skeletal muscle

6) Confidence 0.26 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0.14 Pain Relevance 0.03

As shown, the M values of GNB2L1, HPRT1, and YWHAZ were lower than 0.5; therefore, these genes were concluded to be stably expressed reference genes in human blood.

Regulation (values) of HPRT1 in blood

7) Confidence 0.26 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.