INT88725

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Context Info
Confidence 0.62
First Reported 1999
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 1.28
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HPRT1) small molecule metabolic process (HPRT1) transferase activity, transferring glycosyl groups (HPRT1)
cytoplasm (HPRT1)
Anatomy Link Frequency
blood 1
chondrocytes 1
skeletal muscle 1
brain 1
HPRT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 4 87.52 High High
Dopamine 3 81.68 Quite High
cerebral cortex 2 66.92 Quite High
Neuropathic pain 36 50.00 Quite Low
Calcitonin gene-related peptide 2 15.20 Low Low
Neuropeptide 2 13.92 Low Low
withdrawal 14 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
Eae 10 5.00 Very Low Very Low Very Low
Osteoarthritis 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 1 100.00 Very High Very High Very High
Infection 3 98.32 Very High Very High Very High
Sprains And Strains 2 93.76 High High
Neurodegenerative Disease 10 82.48 Quite High
Syndrome 1 77.88 Quite High
Targeted Disruption 28 77.16 Quite High
Disease 42 75.00 Quite High
Congenital Anomalies 3 75.00 Quite High
Neuropathic Pain 38 50.00 Quite Low
Repression 2 13.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have constructed an adenoviral vector expressing the human HPRT cDNA under the transcriptional control of a short human cytomegalovirus major immediate early promoter (RAd-HPRT).
Regulation (control) of RAd-HPRT associated with cytomegalovirus infection
1) Confidence 0.62 Published 1999 Journal Metab Brain Dis Section Abstract Doc Link 10850548 Disease Relevance 0.42 Pain Relevance 0.09
In our study we have examined the effect of HPRT deficiency on the differentiation of neurons in hNSCs isolated from human LND fetal brain.
Spec (examined) Regulation (effect) of HPRT in brain
2) Confidence 0.45 Published 2010 Journal Hum. Mol. Genet. Section Abstract Doc Link 20159777 Disease Relevance 0.13 Pain Relevance 0.12
For diacerein-treated chondrocytes, GAPDH, B2M, HPRT1 and SDHA were not significantly affected by any culture condition used.


Neg (not) Regulation (affected) of HPRT1 in chondrocytes
3) Confidence 0.29 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1820791 Disease Relevance 0 Pain Relevance 0
RtTA was targeted into the ubiquitously expressed Rosa26 locus, or Sox10 locus, and Runx1a-IRES-EGFP cDNA driven by the tetracycline-responsive element (TRE) targeted upstream the hypoxanthine phosphoribosyltransferase (HPRT) locus.
Regulation (targeted) of hypoxanthine phosphoribosyltransferase
4) Confidence 0.26 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.29 Pain Relevance 0
RtTA was targeted into the ubiquitously expressed Rosa26 locus, or Sox10 locus, and Runx1a-IRES-EGFP cDNA driven by the tetracycline-responsive element (TRE) targeted upstream the hypoxanthine phosphoribosyltransferase (HPRT) locus.
Regulation (targeted) of HPRT
5) Confidence 0.26 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.29 Pain Relevance 0
As shown, the M values of GNB2L1, HPRT1, and YWHAZ were lower than 0.5; therefore, these genes were concluded to be stably expressed reference genes in human skeletal muscle.
Regulation (values) of HPRT1 in skeletal muscle
6) Confidence 0.26 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0.14 Pain Relevance 0.03
As shown, the M values of GNB2L1, HPRT1, and YWHAZ were lower than 0.5; therefore, these genes were concluded to be stably expressed reference genes in human blood.
Regulation (values) of HPRT1 in blood
7) Confidence 0.26 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0 Pain Relevance 0

General Comments

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