INT88726

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 36
Total Number 36
Disease Relevance 10.12
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HPRT1) small molecule metabolic process (HPRT1) transferase activity, transferring glycosyl groups (HPRT1)
cytoplasm (HPRT1)
Anatomy Link Frequency
leukocytes 2
muscle 2
connective tissues 2
blood 1
ligament 1
HPRT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 113 97.72 Very High Very High Very High
metalloproteinase 112 96.88 Very High Very High Very High
Inflammation 127 95.92 Very High Very High Very High
cytokine 112 94.36 High High
anesthesia 24 89.80 High High
adenocard 8 89.44 High High
Pain 48 73.72 Quite High
qutenza 28 73.48 Quite High
COX-2 inhibitor 42 72.52 Quite High
cerebral cortex 2 66.20 Quite High
Disease Link Frequency Relevance Heat
Syndrome 92 100.00 Very High Very High Very High
Crystal Associated Disease 49 99.96 Very High Very High Very High
Sprains And Strains 92 99.44 Very High Very High Very High
Heart Rate Under Development 21 99.40 Very High Very High Very High
Infection 114 98.88 Very High Very High Very High
Cytomegalovirus Infection 8 97.92 Very High Very High Very High
Osteoarthritis 127 97.72 Very High Very High Very High
Necrosis 4 97.44 Very High Very High Very High
Cancer 200 97.08 Very High Very High Very High
Cold Sores 91 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have constructed an adenoviral vector expressing the human HPRT cDNA under the transcriptional control of a short human cytomegalovirus major immediate early promoter (RAd-HPRT).
Gene_expression (expressing) of HPRT cDNA associated with cytomegalovirus infection
1) Confidence 0.78 Published 1999 Journal Metab Brain Dis Section Abstract Doc Link 10850548 Disease Relevance 0.40 Pain Relevance 0.09
Here we show that infection of human 1306, HPRT-negative cells with RAd-HPRT, expressed high enough levels of HPRT enzyme activity, as to reverse their abnormal biochemical phenotype, thus enhancing hypoxanthine incorporation and restoring purine recycling, increasing GTP levels, decreasing adenine incorporation, and allowing cell survival in HAT medium in which only cells expressing high levels of HPRT can survive.
Gene_expression (expressing) of HPRT associated with infection
2) Confidence 0.78 Published 1999 Journal Metab Brain Dis Section Abstract Doc Link 10850548 Disease Relevance 0.49 Pain Relevance 0.07
Most HPRT-deficient patients present HPRT mRNA expression [60], and molecular diagnosis can be accomplished by cDNA sequencing [61].
Gene_expression (expression) of HPRT mRNA
3) Confidence 0.77 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2234399 Disease Relevance 0.13 Pain Relevance 0
For normalization of the data the average of the expression level of four house-keeping genes, GAPDH, HPRT, beta-actin and beta-tubulin, was used.



Gene_expression (expression) of HPRT
4) Confidence 0.75 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0 Pain Relevance 0
This partial deficiency was termed Kelly-Seegmiller syndrome or HPRT-related gout (OMIM 300323).
Gene_expression (syndrome) of HPRT-related associated with syndrome and crystal associated disease
5) Confidence 0.67 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2234399 Disease Relevance 1.08 Pain Relevance 0
(Vandesompele et al., 2002) At least three out of the following four housekeeping genes were used for each experiment: glyceraldehyde-3 phosphate dehydrogenase (GAPDH), hypoxanthine phosphoribosyltransferase 1 (HPRT1), human porphobilinogen deaminase (PBGD) and TATA box binding protein (TBP).
Gene_expression (used) of HPRT1
6) Confidence 0.65 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1481577 Disease Relevance 0.28 Pain Relevance 0
(Vandesompele et al., 2002) At least three out of the following four housekeeping genes were used for each experiment: glyceraldehyde-3 phosphate dehydrogenase (GAPDH), hypoxanthine phosphoribosyltransferase 1 (HPRT1), human porphobilinogen deaminase (PBGD) and TATA box binding protein (TBP).
Gene_expression (used) of hypoxanthine phosphoribosyltransferase 1
7) Confidence 0.65 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1481577 Disease Relevance 0.28 Pain Relevance 0
mRNA and hypoxanthine phosphoribosyltransferase (HPRT) mRNA expression was quantified using QRTPCR.
Gene_expression (expression) of HPRT
8) Confidence 0.65 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2873469 Disease Relevance 0.48 Pain Relevance 0.14
Hypoxanthine and guanine may enter in a salvage pathway, using hypoxanthine-guanine phosphoribosyltranferase (HGPRT), an enzyme that reconverts these purines bases into respective nucleotides.
Gene_expression (using) of HGPRT
9) Confidence 0.65 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 0.71 Pain Relevance 0.11
Results were expressed as the ratio of target gene to HPRT gene expression.


Gene_expression (expression) of HPRT
10) Confidence 0.58 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0 Pain Relevance 0
Data were normalized to an index of three reference genes (GAPDH, UBC, HPRT1) that were pre-evaluated to be stably expressed across samples [39].
Gene_expression (expressed) of HPRT1
11) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.05 Pain Relevance 0
Most HPRT-deficient patients present HPRT mRNA expression [60], and molecular diagnosis can be accomplished by cDNA sequencing [61].
Gene_expression (present) of HPRT-deficient
12) Confidence 0.58 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2234399 Disease Relevance 0.12 Pain Relevance 0
All four house-keeping genes considered in this study (Act-B, GAPDH, hCyPB, HPRT1) were classified as optimal controls and showed stable expression in human leukocytes samples.
Gene_expression (expression) of HPRT1 in leukocytes
13) Confidence 0.52 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588574 Disease Relevance 0 Pain Relevance 0
All the four house-keeping genes tested in this work (Act-B, GAPDH, hCyPB, HPRT1) were classified as optimal controls and showed a constant expression in human leukocytes samples.
Gene_expression (expression) of HPRT1 in leukocytes
14) Confidence 0.52 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2588574 Disease Relevance 0.07 Pain Relevance 0.15
The HPRT1 transcript was selected as the reference gene on an empirical basis—HPRT1 expression in these men (1863±111 arbitrary units, mean±SEM) and women (1881±138 arbitrary units) was similar according to the microarray data (this choice does not necessarily mean that HPRT1 expression always is constant in muscle).
Gene_expression (expression) of HPRT1 in muscle
15) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.09 Pain Relevance 0
The HPRT1 transcript was selected as the reference gene on an empirical basis—HPRT1 expression in these men (1863±111 arbitrary units, mean±SEM) and women (1881±138 arbitrary units) was similar according to the microarray data (this choice does not necessarily mean that HPRT1 expression always is constant in muscle).
Gene_expression (expression) of HPRT1 in muscle
16) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.08 Pain Relevance 0
On the other hand, right branch shows overexpression areas with genes such as CASP 10, CD30-L, and CD-40-L (TNF family), ras-like small, FGF 3 and 5, TDGF1, ERK5, MIF, IFNGR2, MIG, IFN-alpha, beta, gamma, IL-3, -4, -9 and -13, IP-10, HPRT, DCC, TEK, netrin-2, cadherins 4, 8, 12 and 13 [33], MMP3, 8, 10, 12 and 13 (metalloproteinase), COL11A2, CCNG1, CDC-6, ATM, N-MYC, and p53.
Gene_expression (overexpression) of HPRT in TEK associated with metalloproteinase
17) Confidence 0.50 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.79 Pain Relevance 0.05
The geNorm algorithm is employed to investigate the expression stability of 9 commonly used reference genes (glyceraldehyde-3-phosphate dehydrogenase [GAPDH], beta-actin [ACTB], beta-2-microglobulin [B2M] hydroxymethylbilane synthase [HMBS], hypoxanthine guanine phosphoribosyl transferase [HPRT], ribosomal protein L13a [RPL13A], succinate dehydrogenase flavoprotein subunit A [SDHA], TATA box binding protein [TBP] and tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [YWHAZ]) [11] in normal and diseased canine connective tissues.
Gene_expression (expression) of HPRT in connective tissues
18) Confidence 0.48 Published 2007 Journal BMC Vet Res Section Body Doc Link PMC1884148 Disease Relevance 0.67 Pain Relevance 0.22
The geNorm algorithm is employed to investigate the expression stability of 9 commonly used reference genes (glyceraldehyde-3-phosphate dehydrogenase [GAPDH], beta-actin [ACTB], beta-2-microglobulin [B2M] hydroxymethylbilane synthase [HMBS], hypoxanthine guanine phosphoribosyl transferase [HPRT], ribosomal protein L13a [RPL13A], succinate dehydrogenase flavoprotein subunit A [SDHA], TATA box binding protein [TBP] and tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [YWHAZ]) [11] in normal and diseased canine connective tissues.
Gene_expression (expression) of hypoxanthine guanine phosphoribosyl transferase in connective tissues
19) Confidence 0.48 Published 2007 Journal BMC Vet Res Section Body Doc Link PMC1884148 Disease Relevance 0.67 Pain Relevance 0.22
2-fold in the GRB10/HPRT1 or ACVR2B/HPRT1 ratio.


Gene_expression (/) of HPRT1
20) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0 Pain Relevance 0

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