INT88734

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Context Info
Confidence 0.27
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 2.01
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CREM) signal transduction (CREM) nucleus (CREM)
DNA binding (CREM)
CREM (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 30 82.32 Quite High
Pain 73 56.04 Quite High
Post herpetic neuralgia 110 50.00 Quite Low
cINOD 6 50.00 Quite Low
nud 3 50.00 Quite Low
rheumatoid arthritis 2 50.00 Quite Low
antagonist 2 40.00 Quite Low
beta blocker 1 37.44 Quite Low
Neuropathic pain 5 32.76 Quite Low
Osteoarthritis 40 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malaria 279 98.88 Very High Very High Very High
Disease 50 94.24 High High
Polyps 31 87.88 High High
Death 33 81.52 Quite High
Obesity 15 80.16 Quite High
Herpes Zoster 123 72.88 Quite High
Disorder Of Lipid Metabolism 14 70.16 Quite High
Fever 51 68.80 Quite High
Ulcers 4 61.20 Quite High
Pain 70 56.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Each ICER was highly sensitive to variation in the cost of the tests themselves.
Regulation (sensitive) of ICER
1) Confidence 0.27 Published 2000 Journal Can. J. Gastroenterol. Section Body Doc Link 10851277 Disease Relevance 0.06 Pain Relevance 0
According to the sensitivity analyses, QALYs had the highest influence on ICER.
Regulation (influence) of ICER
2) Confidence 0.12 Published 2009 Journal Int J Technol Assess Health Care Section Body Doc Link 19366498 Disease Relevance 0 Pain Relevance 0
The 95% confidence interval for this ratio was estimated using Fieller's Theorem, a technique that includes any correlation between cost and outcome.12 Cost-effectiveness acceptability curves (CEACs), which allow decision-makers to assess the overall probability of a particular threshold, were also estimated.13 A CEAC shows combinations of ceiling values for the ICER and the probabilities that the ICER falls below any given ceiling ratio based on the observed size and variance of differences in cost and events in the trial.
Spec (probabilities) Regulation (values) of ICER
3) Confidence 0.10 Published 2010 Journal European Journal of Heart Failure Section Body Doc Link PMC2796144 Disease Relevance 0 Pain Relevance 0
ICER was sensitive to changes in cost of RDT.
Regulation (sensitive) of ICER
4) Confidence 0.08 Published 2009 Journal Malar J Section Body Doc Link PMC2787522 Disease Relevance 0.27 Pain Relevance 0
ICER was sensitive to deterministic values of malaria prevalence.
Regulation (sensitive) of ICER associated with malaria
5) Confidence 0.08 Published 2009 Journal Malar J Section Body Doc Link PMC2787522 Disease Relevance 0.45 Pain Relevance 0
ICER was very sensitive to a 50% rise in cost of ACT (Table 11).
Regulation (sensitive) of ICER
6) Confidence 0.08 Published 2009 Journal Malar J Section Body Doc Link PMC2787522 Disease Relevance 0.32 Pain Relevance 0
However, using the yardstick that any intervention whose ICER is in excess of three times the per capita GNP is not cost effective, then adding any of the screening programmes to treatment will not be considered as being cost effective.
Neg (not) Regulation (effective) of ICER
7) Confidence 0.06 Published 2010 Journal Cost Eff Resour Alloc Section Body Doc Link PMC2850877 Disease Relevance 0.29 Pain Relevance 0
In women less than age 55, the ICER of MoM HRA is less sensitive to the incremental cost of the HRA implants compared to THA, due to the higher probability of HRA failure in women than in men.Fig. 5A–DThese graphs show two-way sensitivity analyses of incremental cost of HRA compared to primary THA and difference in QoL after conversion from HRA to THA compared to primary THA for (A) men younger than 55 years, (B) men aged 65 to 74 years, (C) women younger than 55 years, and (D) women aged 65 to 74 years.
Regulation (sensitive) of ICER
8) Confidence 0.04 Published 2010 Journal Clin Orthop Relat Res Section Body Doc Link PMC2914258 Disease Relevance 0 Pain Relevance 0
The one-way sensitivity analysis of the ICER to the difference in QoL after conversion from HRA to THA compared to primary THA indicated that the ICER for MoM HRA was very sensitive to the differences in QoL after conversion from HRA to THA for both men and women less than age 55, but not for men age 55–64 (Fig. 3).
Regulation (sensitive) of ICER
9) Confidence 0.04 Published 2010 Journal Clin Orthop Relat Res Section Body Doc Link PMC2914258 Disease Relevance 0 Pain Relevance 0
The sensitivity of the base case ICER to alternative values of significant input parameters was explored by varying these within feasible ranges.
Regulation (sensitivity) of ICER
10) Confidence 0.04 Published 2010 Journal Cost Eff Resour Alloc Section Body Doc Link PMC2881001 Disease Relevance 0.28 Pain Relevance 0.11
The DNA response element conferring PPAR regulation was located to intron 3 of the Angptl4 gene [127].
Regulation (regulation) of DNA response element
11) Confidence 0.00 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.34 Pain Relevance 0.11

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