INT88745

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2000
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.61
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRM3) signal transducer activity (GRM3)
Anatomy Link Frequency
spinal 1
cerebral cortex 1
cerebellum 1
hippocampus 1
GRM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 11 100.00 Very High Very High Very High
Hippocampus 3 99.26 Very High Very High Very High
cerebral cortex 3 99.00 Very High Very High Very High
antidepressant 3 98.40 Very High Very High Very High
Pain 88 98.14 Very High Very High Very High
spinal dorsal horn 2 97.44 Very High Very High Very High
fluoxetine 7 93.60 High High
Glutamate 9 92.84 High High
anesthesia 3 90.92 High High
sSRI 1 90.88 High High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 4 99.44 Very High Very High Very High
Pain 118 98.14 Very High Very High Very High
Injury 10 95.52 Very High Very High Very High
Convulsion 6 94.40 High High
Status Epilepticus 6 89.20 High High
INFLAMMATION 40 87.84 High High
Hyperalgesia 11 87.32 High High
Neuropathic Pain 20 86.20 High High
Neuroblastoma 3 80.80 Quite High
Nociception 9 74.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The patient's serum reacted with rat cerebral cortex, hippocampus, and cerebellum, but not with cells expressing the glutamate receptor GluR3.
Gene_expression (expressing) of GluR3 in cerebral cortex associated with glutamate receptor, hippocampus and cerebral cortex
1) Confidence 0.75 Published 2000 Journal Neurology Section Abstract Doc Link 10851386 Disease Relevance 0.35 Pain Relevance 0.24
These cells expressed mGlu3 receptors negatively coupled to adenylyl cyclase.
Gene_expression (expressed) of mGlu3
2) Confidence 0.75 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18082849 Disease Relevance 0.17 Pain Relevance 0.74
The patient's serum reacted with rat cerebral cortex, hippocampus, and cerebellum, but not with cells expressing the glutamate receptor GluR3.
Gene_expression (expressing) of GluR3 in hippocampus associated with glutamate receptor, hippocampus and cerebral cortex
3) Confidence 0.26 Published 2000 Journal Neurology Section Abstract Doc Link 10851386 Disease Relevance 0.35 Pain Relevance 0.24
The patient's serum reacted with rat cerebral cortex, hippocampus, and cerebellum, but not with cells expressing the glutamate receptor GluR3.
Gene_expression (expressing) of GluR3 in cerebellum associated with glutamate receptor, hippocampus and cerebral cortex
4) Confidence 0.26 Published 2000 Journal Neurology Section Abstract Doc Link 10851386 Disease Relevance 0.35 Pain Relevance 0.24
Metabotropic group II receptors (mGluR2 and mGluR3) also modulate pain transmission. mGluR2 is located in sensory neurones and presynaptic nerve terminals whereas mGluR3 is found all over the brain. mGluR3 can be selectively increased in the spinal dorsal horn neurones after peripheral UV injury [94]. mGluR2/3 receptor activation appears necessary to reduce nerve terminal excitability and to modulate pain transmission since treatment with the agonist L-acetyl carnitine reduced inflammatory hyperalgesia and mechanical allodynia and increased the expression of mGluR2/3.
Gene_expression (found) of mGluR3 in spinal associated with pain, hyperalgesia, allodynia, inflammation, spinal dorsal horn, injury and agonist
5) Confidence 0.17 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.30 Pain Relevance 1.22
We did find low, non-significant levels of Grm3, 6, and 8.
Gene_expression (levels) of Grm3
6) Confidence 0.12 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0.08 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox