INT88746

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Context Info
Confidence 0.51
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.14
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2)
cell-cell signaling (IL2)
Anatomy Link Frequency
T-cell 8
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 4 98.92 Very High Very High Very High
antagonist 36 97.96 Very High Very High Very High
cytokine 120 97.92 Very High Very High Very High
opioid receptor 7 97.16 Very High Very High Very High
mu opioid receptor 2 92.52 High High
Kinase C 2 91.68 High High
Morphine 3 90.96 High High
Inflammation 117 89.60 High High
Serotonin 1 87.44 High High
Sumatriptan 1 86.56 High High
Disease Link Frequency Relevance Heat
Eczema 58 98.88 Very High Very High Very High
Colon Cancer 5 94.48 High High
Organ Transplantation 7 89.80 High High
INFLAMMATION 123 89.60 High High
Asthma 317 86.64 High High
Syndrome 3 82.40 Quite High
Contact Dermatitis 1 81.60 Quite High
Psoriasis 80 81.08 Quite High
Telangiectasia 3 80.80 Quite High
Frailty 2 79.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of IL-2 gene transcription is a critical event for T-cell proliferation and effector functions.
Positive_regulation (induction) of Transcription (transcription) of IL-2 in T-cell
1) Confidence 0.51 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2955679 Disease Relevance 0 Pain Relevance 0
This complex of ciclosporin and cyclophilin inhibits calcineurin, which is responsible for activating the transcription of interleukin-2.
Positive_regulation (activating) of Transcription (transcription) of interleukin-2
2) Confidence 0.26 Published 2009 Journal Clin Transplant Section Abstract Doc Link 19930311 Disease Relevance 0.34 Pain Relevance 0.22
CD3/28 mAb-induced interleukin-2 transcription was also inhibited by the opioids fentanyl and loperamide.
Positive_regulation (mAb-induced) of Transcription (transcription) of interleukin-2 associated with opioid
3) Confidence 0.22 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18463202 Disease Relevance 0 Pain Relevance 0.94
Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor, which is expressed in activated, but not resting T cells and is required for IL-2 gene transcription.
Positive_regulation (required) of Transcription (transcription) of IL-2 gene in T cells
4) Confidence 0.11 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.14 Pain Relevance 0.04
Once a match occurs, T cell gets activated, with increase in the synthesis of mRNA for IL-2 and IL-2 receptor (CD25).
Positive_regulation (increase) of Transcription (synthesis) of IL-2 in T cell
5) Confidence 0.09 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 0.27 Pain Relevance 0.11
Recently immune modulating agents have been demonstrated to increase the proliferative response of PBMC in vitro, probably by inhibition of adenylate cyclase activity and induction of IL-2 mRNA expression.
Positive_regulation (induction) of Transcription (expression) of IL-2
6) Confidence 0.08 Published 1997 Journal Cancer Biother. Radiopharm. Section Abstract Doc Link 10851450 Disease Relevance 0.41 Pain Relevance 0.13
Inhibition of calcineurin results in decreased transcription of IL-2, with resulting decreases in T-cell activation and cytokine production.
Positive_regulation (results) of Transcription (transcription) of IL-2 in T-cell associated with cytokine
7) Confidence 0.02 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770385 Disease Relevance 0.97 Pain Relevance 0.15

General Comments

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