INT88748

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Context Info
Confidence 0.47
First Reported 2000
Last Reported 2005
Negated 0
Speculated 0
Reported most in Title
Documents 7
Total Number 8
Disease Relevance 0
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hcrt)
Anatomy Link Frequency
locus coeruleus 2
nucleus ambiguus 2
ovary 1
Hcrt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 24 100.00 Very High Very High Very High
Locus ceruleus 16 98.96 Very High Very High Very High
Endogenous opioid 2 98.72 Very High Very High Very High
Central nervous system 2 89.84 High High
Opioid 8 89.04 High High
antagonist 4 88.48 High High
narcan 6 80.48 Quite High
tetrodotoxin 4 77.04 Quite High
GABAergic 8 76.32 Quite High
agonist 2 72.96 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the interaction of the orexigenic neuropeptide, hypocretin-1 (Hcrt-1, also known as orexin-A), with endogenous opioids (also orexigenic neuropeptides).
hypocretin-1 Binding (interaction) of associated with endogenous opioid and neuropeptide
1) Confidence 0.47 Published 2004 Journal Peptides Section Abstract Doc Link 15063013 Disease Relevance 0 Pain Relevance 0.56
We investigated the interaction of the orexigenic neuropeptide, hypocretin-1 (Hcrt-1, also known as orexin-A), with endogenous opioids (also orexigenic neuropeptides).
Hcrt-1 Binding (interaction) of associated with endogenous opioid and neuropeptide
2) Confidence 0.47 Published 2004 Journal Peptides Section Abstract Doc Link 15063013 Disease Relevance 0 Pain Relevance 0.56
The binding of [(125)I] orexin-A (Ox-A) to particulates from Chinese hamster ovary (CHO) cells expressing the cloned orexin-A receptor, or from rat forebrain areas, was sensitive to blockers of phosphatidylinositol-specific phospholipase C (PtdIns-PLC) U-73122 and ET-18-OCH(3), little affected by phospholipase A(2) inhibitor quinacrine, and not sensitive to D609, a xanthate inhibitor of phosphatidylcholine-selective PLC.
orexin-A Binding (binding) of in ovary
3) Confidence 0.47 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10860858 Disease Relevance 0 Pain Relevance 0.06
Hypocretin/orexin depolarizes and decreases potassium conductance in locus coeruleus neurons.
Hypocretin/orexin Binding (decreases) of in locus coeruleus associated with locus ceruleus and neuropeptide
4) Confidence 0.37 Published 2000 Journal Neuroreport Section Title Doc Link 10852238 Disease Relevance 0 Pain Relevance 0.57
Hypocretin/orexin depolarizes and decreases potassium conductance in locus coeruleus neurons.
Hypocretin/orexin Binding (decreases) of in locus coeruleus associated with locus ceruleus and neuropeptide
5) Confidence 0.37 Published 2000 Journal Neuroreport Section Title Doc Link 10852238 Disease Relevance 0 Pain Relevance 0.57
Sensitivity of orexin-A binding to phospholipase C inhibitors, neuropeptide Y, and secretin.
orexin-A Binding (binding) of associated with neuropeptide
6) Confidence 0.36 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 10860858 Disease Relevance 0 Pain Relevance 0.30
Hypocretin-1 (orexin-A) facilitates inhibitory and diminishes excitatory synaptic pathways to cardiac vagal neurons in the nucleus ambiguus.
orexin-A Binding (diminishes) of in nucleus ambiguus associated with neuropeptide
7) Confidence 0.36 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 15947034 Disease Relevance 0 Pain Relevance 0.30
Hypocretin-1 (orexin-A) facilitates inhibitory and diminishes excitatory synaptic pathways to cardiac vagal neurons in the nucleus ambiguus.
Hypocretin-1 Binding (diminishes) of in nucleus ambiguus associated with neuropeptide
8) Confidence 0.34 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 15947034 Disease Relevance 0 Pain Relevance 0.30

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