INT88770

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.17
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LIPC) extracellular region (LIPC)
Anatomy Link Frequency
liver 1
LIPC (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 9 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: The aim of this investigation was to study the inhibition of 11 nonsteroidal anti-inflammatory drugs (NSAIDs) on the human liver phenol sulfotransferases (HL-PST) and catechol sulfotransferase (HL-CST).
Negative_regulation (inhibition) of HL-PST in liver associated with inflammation and cinod
1) Confidence 0.37 Published 2000 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 10853883 Disease Relevance 0.17 Pain Relevance 0.28
With 4-nitrophenol as the variable substrate, the inhibition of salicylic acid on HL-PST was non-competitive and the Ki and Kies were 18 microM and 21 microM (n = 5; P = 0.548), respectively.
Negative_regulation (inhibition) of HL-PST
2) Confidence 0.27 Published 2000 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 10853883 Disease Relevance 0 Pain Relevance 0
RESULTS: With the exception of piroxicam, NSAIDs inhibited HL-PST, and the estimates of the inhibitory concentration for 50% of responses (IC50; microM) were: 0.02 (mefenamic acid), 3.7 (diflunisal), 5.4 (nimesulide), 9.5 (diclofenac), 30 (salicylic acid), 41 (ketoprofen), 74 (indomethacin), 159 (ibuprofen), 245 (ketoralac) and 473 (naproxen).
Negative_regulation (inhibited) of HL-PST
3) Confidence 0.27 Published 2000 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 10853883 Disease Relevance 0 Pain Relevance 0

General Comments

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