INT88774

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Context Info
Confidence 0.01
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.13
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (AGT) aging (AGT) Golgi apparatus (Agtrap)
endoplasmic reticulum (Agtrap) extracellular matrix organization (AGT) cell-cell signaling (AGT)
Anatomy Link Frequency
blood 1
plasma 1
AGT (Homo sapiens)
Agtrap (Mus musculus)
Pain Link Frequency Relevance Heat
beta blocker 1 51.60 Quite High
Calcium channel 3 46.88 Quite Low
headache 1 25.12 Quite Low
Bioavailability 3 25.00 Low Low
Potency 1 25.00 Low Low
backache 1 25.00 Low Low
Angina 2 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Disease 1 98.64 Very High Very High Very High
Heart Disease 1 97.64 Very High Very High Very High
Pressure And Volume Under Development 10 97.48 Very High Very High Very High
Increased Venous Pressure Under Development 1 95.84 Very High Very High Very High
Hypertrophy 2 95.24 Very High Very High Very High
Diabetes Mellitus 11 95.20 Very High Very High Very High
Hypotension 4 94.28 High High
Hypertension 8 93.48 High High
Coronary Heart Disease 1 89.64 High High
Myocardial Infarction 17 85.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ARBs specifically block the interaction of angiotensin II at the AT1 receptor, thereby relaxing smooth muscle, increasing salt and water excretion, reducing plasma volume, and decreasing cellular hypertrophy.
angiotensin II Neg (block) Binding (interaction) of AT1 receptor in plasma associated with hypertrophy
1) Confidence 0.01 Published 2000 Journal J Hum Hypertens Section Abstract Doc Link 10854085 Disease Relevance 0.88 Pain Relevance 0.03
The binding of angiotensin II to an AT1 receptor produces a number of potentially harmful effects that include increased blood pressure, progression of atherosclerosis, myocardial-, and vascular hypertrophy.
angiotensin II Binding (binding) of AT1 receptor in blood associated with hypertrophy, pressure and volume under development and increased venous pressure under development
2) Confidence 0.00 Published 2010 Journal J Hum Hypertens Section Body Doc Link PMC2834374 Disease Relevance 1.25 Pain Relevance 0

General Comments

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