INT88785

Context Info Confidence 0.06 First Reported 2000 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 2.51 Pain Relevance 1.55

cytoskeletal protein binding (Epb4.1l5) cytoskeleton (Epb4.1l5) cytoplasm (Epb4.1l5)

Anatomy Link Frequency sciatic nerve 1 spinal cords 1 Epb4.1l5 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Sciatic nerve 45 99.34 Eae 101 98.92 Hyperalgesia 10 95.84 Neuropathic pain 40 90.12 Pain 7 88.28 Spinal cord 11 75.00 Central nervous system 1 74.92 analgesia 1 64.80 Inflammation 26 37.44 cytokine 70 36.40

Disease Link Frequency Relevance Heat Injury 126 99.88 Hyperalgesia 28 95.84 Neuropathic Pain 72 90.12 Pain 9 88.28 Diabetic Nephropathy 1 85.16 Aging 1 78.24 Nervous System Injury 41 77.00 Syndrome 1 72.52 INFLAMMATION 26 37.44 Wallerian Degeneration 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

On various days post injury, the L4-L5 levels of their spinal cords were reacted for localization of an antibody to OX-42, a marker for microlgia.

Positive_regulation (reacted) of L4-L5 in spinal cords associated with injury

1) Confidence 0.06 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10854727 Disease Relevance 1.50 Pain Relevance 0.88

The sham operation for 3 days induced a significant increase of IL-10 protein in the ipsilateral L4-L5 DRG.

Positive_regulation (increase) of L4-L5

2) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.36 Pain Relevance 0.22

Unilateral CCI of the sciatic nerve induced a significant bilateral increase of IL-10 protein level in L4-L5 DRG as early as 1 day from the operation.

Positive_regulation (increase) of L4-L5 in sciatic nerve associated with eae and sciatic nerve

3) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.65 Pain Relevance 0.45

General Comments

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