INT88785

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Context Info
Confidence 0.06
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.51
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Epb4.1l5) cytoskeleton (Epb4.1l5) cytoplasm (Epb4.1l5)
Anatomy Link Frequency
sciatic nerve 1
spinal cords 1
Epb4.1l5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 45 99.34 Very High Very High Very High
Eae 101 98.92 Very High Very High Very High
Hyperalgesia 10 95.84 Very High Very High Very High
Neuropathic pain 40 90.12 High High
Pain 7 88.28 High High
Spinal cord 11 75.00 Quite High
Central nervous system 1 74.92 Quite High
analgesia 1 64.80 Quite High
Inflammation 26 37.44 Quite Low
cytokine 70 36.40 Quite Low
Disease Link Frequency Relevance Heat
Injury 126 99.88 Very High Very High Very High
Hyperalgesia 28 95.84 Very High Very High Very High
Neuropathic Pain 72 90.12 High High
Pain 9 88.28 High High
Diabetic Nephropathy 1 85.16 High High
Aging 1 78.24 Quite High
Nervous System Injury 41 77.00 Quite High
Syndrome 1 72.52 Quite High
INFLAMMATION 26 37.44 Quite Low
Wallerian Degeneration 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On various days post injury, the L4-L5 levels of their spinal cords were reacted for localization of an antibody to OX-42, a marker for microlgia.
Positive_regulation (reacted) of L4-L5 in spinal cords associated with injury
1) Confidence 0.06 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10854727 Disease Relevance 1.50 Pain Relevance 0.88
The sham operation for 3 days induced a significant increase of IL-10 protein in the ipsilateral L4-L5 DRG.
Positive_regulation (increase) of L4-L5
2) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.36 Pain Relevance 0.22
Unilateral CCI of the sciatic nerve induced a significant bilateral increase of IL-10 protein level in L4-L5 DRG as early as 1 day from the operation.
Positive_regulation (increase) of L4-L5 in sciatic nerve associated with eae and sciatic nerve
3) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.65 Pain Relevance 0.45

General Comments

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