INT88786

Context Info Confidence 0.46 First Reported 2000 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 11 Total Number 12 Disease Relevance 2.73 Pain Relevance 6.58

plasma membrane (Dlg4) protein complex assembly (Dlg4) response to stress (Dlg4) cytoplasm (Dlg4)

Anatomy Link Frequency synapse 4 spinal cord neurons 2 spinal 1 brain 1 peripheral nerve 1 Dlg4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Spinal cord 14 99.80 nMDA receptor 30 99.76 Morphine 27 99.22 Neurobehavioral 3 98.72 Opioid 5 98.22 spinal dorsal horn 4 98.04 Thermal hyperalgesia 10 96.84 Dorsal horn 4 96.16 Inflammation 10 95.60 Peripheral nerve injury 2 95.48

Disease Link Frequency Relevance Heat Cognitive Disorder 9 98.92 Hyperalgesia 16 96.84 INFLAMMATION 7 95.60 Nervous System Injury 4 95.04 Neuropathic Pain 5 94.20 Nociception 3 93.64 Injury 1 66.48 Disease 14 5.00 Intellectual Impairment 6 5.00 Stress 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results are particularly important for a better understanding of certain opioid-mediated neurobehavioral cognitive changes in offspring associated with altered protein interaction between PSD-95 and NMDAR subunits within the developing brain.

PSD-95 Binding (interaction) of in brain associated with cognitive disorder, neurobehavioral and opioid

1) Confidence 0.46 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.23 Pain Relevance 0.64

Furthermore, the protein interaction of the synaptic complex between the PSD-95 and NMDAR subunit, as indicated by coimmunoprecipitation, was less in prenatal morphine samples than in vehicle controls (P14 and P45).

PSD-95 Binding (interaction) of associated with morphine

2) Confidence 0.46 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.15 Pain Relevance 0.78

In this study, we determined whether prenatal morphine exposure altered the synaptic complex association between PSD-95 and three major NMDAR subunits (NR1, NR2A, and NR2B), at the mRNA and protein levels, within the hippocampal CA1 subregion (an important integration area for mammalian learning and memory) of rat offspring along with the performance of long-term cognitive functions.

PSD-95 Binding (association) of associated with cognitive disorder and morphine

3) Confidence 0.36 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.17 Pain Relevance 0.51

Postsynaptic density-95 (PSD-95)/synapse-associated protein-90 (SAP90), a molecular scaffolding protein that binds and clusters the NMDA receptor perferentially at synapses, was implicated in NMDA-induced thermal hyperalgesia.

SAP90 Binding (binds) of in synapse associated with thermal hyperalgesia and nmda receptor

4) Confidence 0.36 Published 2001 Journal Anesthesiology Section Abstract Doc Link 11465592 Disease Relevance 0.19 Pain Relevance 0.31

Postsynaptic density-95 (PSD-95)/synapse-associated protein-90 (SAP90), a molecular scaffolding protein that binds and clusters the NMDA receptor perferentially at synapses, was implicated in NMDA-induced thermal hyperalgesia.

PSD-95 Binding (binds) of in synapse associated with thermal hyperalgesia and nmda receptor

5) Confidence 0.31 Published 2001 Journal Anesthesiology Section Abstract Doc Link 11465592 Disease Relevance 0.19 Pain Relevance 0.31

Postsynaptic density-95 (PSD-95)/synapse-associated protein-90 (SAP90), a molecular scaffolding protein that binds and clusters the NMDA receptor perferentially at synapses, was implicated in NMDA-induced thermal hyperalgesia.

synapse-associated protein-90 Binding (binds) of in synapse associated with thermal hyperalgesia and nmda receptor

6) Confidence 0.31 Published 2001 Journal Anesthesiology Section Abstract Doc Link 11465592 Disease Relevance 0.19 Pain Relevance 0.31

Our previous work has demonstrated that postsynaptic density protein-95, a molecular scaffolding protein that binds and clusters N-methyl-D-aspartate receptors at neuronal synapses, plays an important role in the development of peripheral nerve injury-induced neuropathic pain.

postsynaptic density protein-95 Binding (binds) of in peripheral nerve associated with nervous system injury, nmda receptor, neuropathic pain and peripheral nerve injury

7) Confidence 0.31 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617977 Disease Relevance 0.56 Pain Relevance 0.46

Coimmunoprecipitation indicates that Shank, a postsynaptic density protein associated with mGluRs, formed a complex involving PSD-95 (postsynaptic density-95), NR2B, and Src in the spinal dorsal horn.

PSD-95 Binding (complex) of in spinal associated with spinal dorsal horn

8) Confidence 0.26 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15483135 Disease Relevance 0.58 Pain Relevance 1.19

In spinal cord neurons, PSD-95/SAP90 interacted with the N-methyl-D-aspartate receptor subunits 2A/2B.

SAP90 Binding (interacted) of in spinal cord neurons associated with nmda receptor and spinal cord

9) Confidence 0.18 Published 2000 Journal Neuroscience Section Abstract Doc Link 10854750 Disease Relevance 0.24 Pain Relevance 1.01

In spinal cord neurons, PSD-95/SAP90 interacted with the N-methyl-D-aspartate receptor subunits 2A/2B.

PSD-95 Binding (interacted) of in spinal cord neurons associated with nmda receptor and spinal cord

10) Confidence 0.18 Published 2000 Journal Neuroscience Section Abstract Doc Link 10854750 Disease Relevance 0.24 Pain Relevance 1.01

Based on drawing an analogy to the interaction between GluN2 and PSD-95, the interaction between GluA1 and SAP97 was identified by directly testing the interaction [90].

PSD-95 Binding (interaction) of

11) Confidence 0.03 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.06

In the synapse, the C-termini of stargazin/TARP and CKAMP44 interact with the synaptic scaffold proteins such as PSD-95 that belongs to the membrane associated guanylate kinase (MAGUK) family

PSD-95 Binding (interact) of in synapse

12) Confidence 0.03 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0

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