INT88787

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.83
Pain Relevance 4.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlg4) protein complex assembly (Dlg4) response to stress (Dlg4)
cytoplasm (Dlg4)
Anatomy Link Frequency
spinal cord 2
shell 1
Dlg4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 10 100.00 Very High Very High Very High
Dorsal horn 2 99.20 Very High Very High Very High
Morphine 27 99.06 Very High Very High Very High
tail-flick 4 98.92 Very High Very High Very High
gABA 5 98.62 Very High Very High Very High
nMDA receptor 20 97.36 Very High Very High Very High
Nucleus accumbens 7 96.60 Very High Very High Very High
Central nervous system 2 89.04 High High
Hyperalgesia 2 77.20 Quite High
dopamine receptor 2 76.00 Quite High
Disease Link Frequency Relevance Heat
Cognitive Disorder 6 92.76 High High
Hyperalgesia 6 77.20 Quite High
Apoptosis 1 62.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The real-time polymerase chain reaction results showed that prenatal morphine exposure caused significant decreases in mRNA levels of the PSD-95 and three NMDAR subunits (NR1, NR2A, and NR2B) in offspring (P14 and P45).
Transcription (levels) of PSD-95 associated with morphine
1) Confidence 0.69 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.16 Pain Relevance 0.65
In this study, we determined whether prenatal morphine exposure altered the synaptic complex association between PSD-95 and three major NMDAR subunits (NR1, NR2A, and NR2B), at the mRNA and protein levels, within the hippocampal CA1 subregion (an important integration area for mammalian learning and memory) of rat offspring along with the performance of long-term cognitive functions.
Transcription (mRNA) of PSD-95 associated with cognitive disorder and morphine
2) Confidence 0.51 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.17 Pain Relevance 0.52
Moreover, PSD-95/SAP90's messenger RNA and protein were enriched in the spinal cord and selectively distributed in the superficial dorsal horn, where PSD-95/SAP90 overlapped with the N-methyl-D-aspartate receptor.
Transcription (distributed) of SAP90 in spinal cord associated with nmda receptor, dorsal horn and spinal cord
3) Confidence 0.34 Published 2000 Journal Neuroscience Section Abstract Doc Link 10854750 Disease Relevance 0.22 Pain Relevance 0.99
Moreover, PSD-95/SAP90's messenger RNA and protein were enriched in the spinal cord and selectively distributed in the superficial dorsal horn, where PSD-95/SAP90 overlapped with the N-methyl-D-aspartate receptor.
Transcription (distributed) of PSD-95 in spinal cord associated with nmda receptor, dorsal horn and spinal cord
4) Confidence 0.34 Published 2000 Journal Neuroscience Section Abstract Doc Link 10854750 Disease Relevance 0.22 Pain Relevance 0.99
Comparison of gene expression between the shell and core subregions of vehicle-treated rats revealed significantly higher relative abundance of GABA-A alpha1, Galphai2 and post-synaptic density protein 95 transcript (PSD-95) mRNA levels in the shell, whereas Ggamma2 and synuclein 1 were more abundant in the core of the NAc.
Transcription (levels) of PSD-95 in shell associated with nucleus accumbens and gaba
5) Confidence 0.25 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.06 Pain Relevance 0.95

General Comments

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