INT88790

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.53
Pain Relevance 4.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlg4) protein complex assembly (Dlg4) response to stress (Dlg4)
cytoplasm (Dlg4)
Anatomy Link Frequency
spinal cord 4
tail 2
Dlg4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 11 100.00 Very High Very High Very High
depression 6 100.00 Very High Very High Very High
Morphine 33 99.70 Very High Very High Very High
nMDA receptor 12 99.20 Very High Very High Very High
Central nervous system 3 98.68 Very High Very High Very High
Thermal hyperalgesia 5 97.92 Very High Very High Very High
tail-flick 2 97.16 Very High Very High Very High
tolerance 8 95.56 Very High Very High Very High
Dextromethorphan 6 93.00 High High
intrathecal 1 90.60 High High
Disease Link Frequency Relevance Heat
Depression 6 100.00 Very High Very High Very High
Hyperalgesia 6 97.92 Very High Very High Very High
Injury 1 91.24 High High
Morphine Dependence 4 88.04 High High
Neuropathic Pain 5 86.24 High High
Nervous System Injury 4 83.44 Quite High
Opiate Addiction 2 70.48 Quite High
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Co-administration of morphine twice daily and PSD-95 antisense oligodeoxynucleotide (50 microg/10 microl) once daily for 4 days not only markedly reduced the PSD-95 expression and its binding to NMDA receptors in spinal cord but also significantly prevented the development of morphine tolerance.
Negative_regulation (reduced) of Gene_expression (expression) of PSD-95 in spinal cord associated with nmda receptor, tolerance, spinal cord and morphine
1) Confidence 0.59 Published 2004 Journal Neuroscience Section Abstract Doc Link 14667437 Disease Relevance 0 Pain Relevance 1.29
RESULTS: The expression of BDNF and PSD-95 in hippocampal CA1 decreased in the withdrawn group with morphine dependence for 1 week as compared with that in normal saline (NS) group (P < 0.01), and it increased in the withdrawn group with morphine dependence for 2 weeks as compared with that in morphine-dependent group for 1 week (P < 0.05) but still decreased as compared with that in NS group (P < 0.01), and it decreased in the withdrawn group with morphine dependence for 4 weeks as compared with the other three groups (P < 0.01).
Negative_regulation (decreased) of Gene_expression (expression) of PSD-95
2) Confidence 0.42 Published 2008 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 18630696 Disease Relevance 0.09 Pain Relevance 0
CONCLUSION: The expression of BDNF and PSD-95 in hippocampal CA1 decreases in morphine-depended rats withdrawn for 1 week.
Negative_regulation (decreases) of Gene_expression (expression) of PSD-95
3) Confidence 0.42 Published 2008 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 18630696 Disease Relevance 0.07 Pain Relevance 0
The rats injected intrathecally with postsynaptic density protein-95 antisense oligodeoxynucleotide every 24 h for 4 days from day 7 to day 10 post-surgery exhibited not only a marked decrease in spinal cord postsynaptic density protein-95 protein expression but also a significant reduction in mechanical and thermal hyperalgesia on day 11 post-surgery.
Negative_regulation (decrease) of Gene_expression (expression) of postsynaptic density protein-95 in spinal cord associated with thermal hyperalgesia and spinal cord
4) Confidence 0.37 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617977 Disease Relevance 0.76 Pain Relevance 0.65
The results revealed that prenatal morphine exposure caused a maximal decrease in PSD-95 expression at P14 followed by an age-dependent improvement.
Negative_regulation (decrease) of Gene_expression (expression) of PSD-95 associated with morphine
5) Confidence 0.35 Published 2006 Journal Hippocampus Section Abstract Doc Link 16598705 Disease Relevance 0.23 Pain Relevance 1.05
Collectively, the study demonstrates that maternal exposure to morphine decreases the magnitude of PSD-95, nNOS, the phosphorylation of CREB(Serine-133), and LTD expression in hippocampal CA1 subregion of young offspring (e.g., P14).
Negative_regulation (magnitude) of Gene_expression (expression) of PSD-95 associated with depression and morphine
6) Confidence 0.35 Published 2006 Journal Hippocampus Section Abstract Doc Link 16598705 Disease Relevance 0.27 Pain Relevance 0.93
Here, we present evidence that suppression of the expression of PSD-95/SAP90 in the spinal cord significantly attenuated facilitation of the tail-flick reflex triggered through N-methyl-D-aspartate receptor activation but not baseline tail-flick reflex latency.
Negative_regulation (suppression) of Gene_expression (expression) of PSD-95 in tail associated with nmda receptor, tail-flick and spinal cord
7) Confidence 0.29 Published 2000 Journal Neuroscience Section Abstract Doc Link 10854750 Disease Relevance 0.13 Pain Relevance 0.74

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