INT88805

Context Info Confidence 0.86 First Reported 2000 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 24 Total Number 24 Disease Relevance 18.38 Pain Relevance 3.70

nucleoplasm (CASP3) mitochondrion (CASP3) cytoplasm (CASP3) cytosol (CASP3) peptidase activity (CASP3) nucleolus (CASP3)

Anatomy Link Frequency cleavage 10 poly 2 HL-60 1 MDA-MB-231 1 CASP3 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 214 98.92 Chronic low back pain 44 98.16 COX-2 inhibitor 54 97.04 bradykinin 75 94.64 cINOD 37 92.28 Pain 72 91.36 backache 50 90.64 Angina 1 85.28 cytokine 41 84.96 local anesthetic 1 78.20

Disease Link Frequency Relevance Heat Apoptosis 696 99.72 Stress 168 99.42 INFLAMMATION 226 98.92 Death 196 98.80 Photosensitivity Disorders 1 98.80 Low Back Pain 94 97.84 Lung Cancer 17 95.96 Carcinoma 5 95.12 Disease 378 94.32 Leukemia 12 94.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Western blot analysis showed that indomethacin treatment led both to decrease in procaspase-3 and to cleavage of its substrate poly(ADP-ribose) polymerase (PARP).

Protein_catabolism (cleavage) of caspase-3 in poly

1) Confidence 0.86 Published 2000 Journal Int J Colorectal Dis Section Abstract Doc Link 10855553 Disease Relevance 1.00 Pain Relevance 0.53

In addition, PAB also inhibited bcl-x(L) expression, induced cleavage of procaspase-3 and its substrate poly(ADP-ribose) polymerase (PARP), which together caused DNA fragmentation and nuclear chromatin condensation.

Protein_catabolism (cleavage) of procaspase-3 in cleavage

2) Confidence 0.86 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17258704 Disease Relevance 0.70 Pain Relevance 0.15

The dose-dependent induction of apoptosis by ropivacaine was demonstrated by DNA fragmentation analysis and the proteolytic cleavage of a caspase-3 substrate-poly (ADP-ribose) polymerase (PARP).

Protein_catabolism (cleavage) of caspase-3 in poly associated with apoptosis

3) Confidence 0.49 Published 2004 Journal Cell Res. Section Abstract Doc Link 15538973 Disease Relevance 0.64 Pain Relevance 0.08

Furthermore, this apoptosis was accompanied by the cleavage of procaspase-9 and -3, and poly(ADP-ribose) polymerase (PARP) in the MCF-7 cells, and procaspase-8 and -3 and PARP in the MDA-MB-231 cells.

Protein_catabolism (cleavage) of procaspase-9 in MDA-MB-231 associated with apoptosis

4) Confidence 0.46 Published 2006 Journal Oncol. Rep. Section Abstract Doc Link 16685380 Disease Relevance 1.07 Pain Relevance 0.09

A pan-caspase inhibitor, z-VAD-fmk, suppressed this increase in apoptosis and also suppressed the cleavage of caspase-8, caspase-3, and PARP, suggesting a caspase-dependent mechanism.

Protein_catabolism (cleavage) of caspase-3 in cleavage associated with apoptosis

5) Confidence 0.43 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19360361 Disease Relevance 0.58 Pain Relevance 0.27

The combined nimesulide-radiation treatment increased apoptosis, induced the cleavage of caspase-3, caspase-9, and poly(ADP-ribose) polymerase (PARP), activated caspase-8, and induced cleavage of Bid.

Protein_catabolism (cleavage) of caspase-3 in cleavage associated with apoptosis

6) Confidence 0.43 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19360361 Disease Relevance 0.59 Pain Relevance 0.30

Derivatives induced apoptosis was mediated by the cleavage and activation of caspase-9 and caspase-3, but not caspase 8, implicating the mitochondrial pathway for apoptosis induction.

Protein_catabolism (cleavage) of caspase-3 in cleavage associated with apoptosis

7) Confidence 0.35 Published 2005 Journal Int. J. Cancer Section Abstract Doc Link 15499625 Disease Relevance 1.33 Pain Relevance 0.12

m can disturb intracellular ATP synthesis, generation of reactive oxygen species (ROS), altered mitochondrial redox ratio, translocation of cyto c to the cytosol, and degradation of caspase-3/PARP[9-12].

Protein_catabolism (degradation) of caspase-3

8) Confidence 0.26 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0.91 Pain Relevance 0

This results in unique profiles of stress-induced MAPK activation and caspase-3 cleavage, as well as downstream events such as cell death.

Protein_catabolism (cleavage) of caspase-3 in cleavage associated with stress and death

9) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.58 Pain Relevance 0.12

We also found that NCTD significantly increased the cleavage of pro-caspase-3 to the active form in a dose-dependent manner (Table 1 & Figure 6B).

Protein_catabolism (cleavage) of caspase-3 in cleavage

10) Confidence 0.17 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0.86 Pain Relevance 0

Expression of caspase-3 was graded in a semiquantitative manner using a two-tier scale: (0) = staining cells <30% of the inflammatory infiltrate or (1+) = staining >30% of the inflammatory infiltrate.

Protein_catabolism (graded) of caspase-3 associated with inflammation

11) Confidence 0.15 Published 2006 Journal Head Face Med Section Body Doc Link PMC1524725 Disease Relevance 0.63 Pain Relevance 0.24

Caspase-3 is an executor caspase that can be cleaved or activated by either caspase-9, the initiator caspase of the mitochondrial pathway, or caspase-8, the initiator caspase of the death receptor pathway.

Protein_catabolism (cleaved) of Caspase-3 associated with death

12) Confidence 0.14 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.64 Pain Relevance 0

Therefore, the fact that we did not find cells immunopositive for both TH and cleaved caspase-3, does not clarify the issue.

Protein_catabolism (cleaved) of caspase-3

13) Confidence 0.09 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525922 Disease Relevance 0.14 Pain Relevance 0.07

The study will be a randomised controlled trial comparing graded activity and motor control exercise for patients with chronic low back pain.

Protein_catabolism (graded) of activity associated with low back pain and chronic low back pain

14) Confidence 0.08 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2409320 Disease Relevance 0.50 Pain Relevance 0.50

These results were correlated with caspase-3 and PARP cleavage and Bcl-2 degradation.

Protein_catabolism (degradation) of caspase-3 in cleavage

15) Confidence 0.07 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.58 Pain Relevance 0.15

Interestingly, pretreatment with Ocimum gratissimum extract reduced the level of cleaved caspase-3 and cleaved caspase-9, but only slightly affected the level of cleaved caspase-8, suggesting that OGE's protective effects mainly influence the mitochondrial pathway.

Protein_catabolism (cleaved) of caspase-3

16) Confidence 0.06 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.15 Pain Relevance 0

In addition, the cleavage of the caspase-3 substrate PARP (115 kDa) and generation of the small fragment (23-kDa) in the co-treated cells were also significantly enhanced (Figure 2C and 2D).

Protein_catabolism (cleavage) of caspase-3 in cleavage

17) Confidence 0.06 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 1.06 Pain Relevance 0

One hundred and seventy two participants will be randomly allocated to receive either a program of motor control exercises or graded activity.

Protein_catabolism (graded) of activity

18) Confidence 0.05 Published 2008 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2409320 Disease Relevance 0.55 Pain Relevance 0.55

Procaspase 3 was most markedly decreased in the NT group (0.62±0.08 a.u.) compared to sham control (1.25±0.18 a.u.) indicating cleavage of inactive procaspase 3 to caspase 3 (p<0.001; Figure 4C, D).

Protein_catabolism (cleavage) of procaspase 3 in cleavage

19) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764338 Disease Relevance 0.25 Pain Relevance 0.04

This finding was supported by staining for annexin V and cleaved caspase-3 [37].

Protein_catabolism (cleaved) of caspase-3

20) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.03 Pain Relevance 0.03

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