INT88805
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Western blot analysis showed that indomethacin treatment led both to decrease in procaspase-3 and to cleavage of its substrate poly(ADP-ribose) polymerase (PARP). | |||||||||||||||
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In addition, PAB also inhibited bcl-x(L) expression, induced cleavage of procaspase-3 and its substrate poly(ADP-ribose) polymerase (PARP), which together caused DNA fragmentation and nuclear chromatin condensation. | |||||||||||||||
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The dose-dependent induction of apoptosis by ropivacaine was demonstrated by DNA fragmentation analysis and the proteolytic cleavage of a caspase-3 substrate-poly (ADP-ribose) polymerase (PARP). | |||||||||||||||
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Furthermore, this apoptosis was accompanied by the cleavage of procaspase-9 and -3, and poly(ADP-ribose) polymerase (PARP) in the MCF-7 cells, and procaspase-8 and -3 and PARP in the MDA-MB-231 cells. | |||||||||||||||
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A pan-caspase inhibitor, z-VAD-fmk, suppressed this increase in apoptosis and also suppressed the cleavage of caspase-8, caspase-3, and PARP, suggesting a caspase-dependent mechanism. | |||||||||||||||
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The combined nimesulide-radiation treatment increased apoptosis, induced the cleavage of caspase-3, caspase-9, and poly(ADP-ribose) polymerase (PARP), activated caspase-8, and induced cleavage of Bid. | |||||||||||||||
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Derivatives induced apoptosis was mediated by the cleavage and activation of caspase-9 and caspase-3, but not caspase 8, implicating the mitochondrial pathway for apoptosis induction. | |||||||||||||||
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m can disturb intracellular ATP synthesis, generation of reactive oxygen species (ROS), altered mitochondrial redox ratio, translocation of cyto c to the cytosol, and degradation of caspase-3/PARP[9-12]. | |||||||||||||||
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This results in unique profiles of stress-induced MAPK activation and caspase-3 cleavage, as well as downstream events such as cell death.
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We also found that NCTD significantly increased the cleavage of pro-caspase-3 to the active form in a dose-dependent manner (Table 1 & Figure 6B). | |||||||||||||||
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Expression of caspase-3 was graded in a semiquantitative manner using a two-tier scale: (0) = staining cells <30% of the inflammatory infiltrate or (1+) = staining >30% of the inflammatory infiltrate.
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Caspase-3 is an executor caspase that can be cleaved or activated by either caspase-9, the initiator caspase of the mitochondrial pathway, or caspase-8, the initiator caspase of the death receptor pathway. | |||||||||||||||
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Therefore, the fact that we did not find cells immunopositive for both TH and cleaved caspase-3, does not clarify the issue. | |||||||||||||||
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The study will be a randomised controlled trial comparing graded activity and motor control exercise for patients with chronic low back pain. | |||||||||||||||
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These results were correlated with caspase-3 and PARP cleavage and Bcl-2 degradation. | |||||||||||||||
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Interestingly, pretreatment with Ocimum gratissimum extract reduced the level of cleaved caspase-3 and cleaved caspase-9, but only slightly affected the level of cleaved caspase-8, suggesting that OGE's protective effects mainly influence the mitochondrial pathway. | |||||||||||||||
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In addition, the cleavage of the caspase-3 substrate PARP (115 kDa) and generation of the small fragment (23-kDa) in the co-treated cells were also significantly enhanced (Figure 2C and 2D). | |||||||||||||||
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One hundred and seventy two participants will be randomly allocated to receive either a program of motor control exercises or graded activity. | |||||||||||||||
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Procaspase 3 was most markedly decreased in the NT group (0.62±0.08 a.u.) compared to sham control (1.25±0.18 a.u.) indicating cleavage of inactive procaspase 3 to caspase 3 (p<0.001; Figure 4C, D). | |||||||||||||||
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This finding was supported by staining for annexin V and cleaved caspase-3 [37]. | |||||||||||||||
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