INT8881

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Context Info
Confidence 0.61
First Reported 1982
Last Reported 2009
Negated 6
Speculated 3
Reported most in Abstract
Documents 38
Total Number 41
Disease Relevance 17.49
Pain Relevance 27.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tacr1) response to stress (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
neurons 9
spinal cord 6
hippocampus 5
brain 4
spinal 4
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 352 100.00 Very High Very High Very High
Spinal cord 221 100.00 Very High Very High Very High
Inflammation 207 100.00 Very High Very High Very High
Pain 202 100.00 Very High Very High Very High
qutenza 109 100.00 Very High Very High Very High
Dorsal horn 102 100.00 Very High Very High Very High
antagonist 33 100.00 Very High Very High Very High
Morphine 28 100.00 Very High Very High Very High
antidepressant 18 100.00 Very High Very High Very High
Analgesic 12 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 246 100.00 Very High Very High Very High
INFLAMMATION 211 100.00 Very High Very High Very High
Stress 82 100.00 Very High Very High Very High
Death 6 99.92 Very High Very High Very High
Ganglion Cysts 487 99.84 Very High Very High Very High
Nociception 288 99.84 Very High Very High Very High
Inflammatory Pain 28 99.68 Very High Very High Very High
Dyspepsia 6 99.50 Very High Very High Very High
Wound Healing 5 99.08 Very High Very High Very High
Pressure And Volume Under Development 10 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neonatal capsaicin treatment affects rat thymocyte proliferation and cell death by modulating substance P and neurokinin-1 receptor expression.
Regulation (modulating) of Gene_expression (expression) of neurokinin-1 receptor in thymocyte associated with qutenza, death and substance p
1) Confidence 0.61 Published 2004 Journal Neuroimmunomodulation Section Title Doc Link 15067207 Disease Relevance 0.43 Pain Relevance 1.26
Overall, our results strongly suggest that the immunomodulatory effects of neonatal CPS treatment on rat thymocyte functions are dependent on vanilloid-mediated regulation of SP and NK-1R functional expression by neuronal and immune cells.
Regulation (regulation) of Gene_expression (expression) of NK-1R in neuronal associated with qutenza and substance p
2) Confidence 0.61 Published 2004 Journal Neuroimmunomodulation Section Abstract Doc Link 15067207 Disease Relevance 0.19 Pain Relevance 1.12
Central and peripheral expression of neurokinin-1 and neurokinin-3 receptor and substance P-encoding messenger RNAs: peripheral regulation during formalin-induced inflammation and lack of neurokinin receptor expression in primary afferent sensory neurons.
Regulation (regulation) of Gene_expression (expression) of neurokinin-1 in sensory neurons associated with inflammation and substance p
3) Confidence 0.45 Published 1999 Journal Neuroscience Section Title Doc Link 10430499 Disease Relevance 0.40 Pain Relevance 0.43
Central and peripheral expression of neurokinin-1 and neurokinin-3 receptor and substance P-encoding messenger RNAs: peripheral regulation during formalin-induced inflammation and lack of neurokinin receptor expression in primary afferent sensory neurons.
Regulation (regulation) of Gene_expression (expression) of neurokinin receptor in sensory neurons associated with inflammation and substance p
4) Confidence 0.45 Published 1999 Journal Neuroscience Section Title Doc Link 10430499 Disease Relevance 0.42 Pain Relevance 0.47
Morphine application altered neurokinin-1 and neurokinin-2 receptor expression in inflammatory and parenchymal cells essential for wound healing in a cell-specific manner, demonstrating a direct effect of morphine on neurokinin receptor regulation within an array of cells involved in wound healing.
Regulation (altered) of Gene_expression (expression) of neurokinin-1 in parenchymal cells associated with inflammation, wound healing and morphine
5) Confidence 0.43 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19428329 Disease Relevance 1.24 Pain Relevance 1.49
Therefore, we investigated the effects of immobilization stress or inflammatory stimuli on NK-1 receptor and BDNF gene expression in the rat hippocampus.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of NK-1 receptor in hippocampus associated with stress, hippocampus and inflammatory stimuli
6) Confidence 0.43 Published 2005 Journal Neuroscience Section Abstract Doc Link 15964488 Disease Relevance 1.19 Pain Relevance 0.65
Injection of a modest dose (175 ng) of SP-sap into the lumbar subarachnoid space produced a partial loss of lamina I/II NK-1R-expressing dorsal horn neurons but did not affect NK-1R-expressing neurons in deeper laminae.
Neg (not) Regulation (affect) of Gene_expression (expressing) of NK-1R-expressing in neurons associated with dorsal horn neuron
7) Confidence 0.39 Published 2003 Journal Neuroscience Section Abstract Doc Link 12763083 Disease Relevance 0.15 Pain Relevance 0.46
Effects of analgesic or antidepressant drugs on pain- or stress-evoked hippocampal and spinal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression in the rat.
Regulation (Effects) of Gene_expression (expression) of neurokinin-1 receptor in brain associated with stress, pain, antidepressant and analgesic
8) Confidence 0.38 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16956981 Disease Relevance 1.28 Pain Relevance 1.61
DE inhalation affected the SP signaling processes, including stored SP depletion and the gene/protein overexpression for neurokinin-1 receptor.
Regulation (affected) of Gene_expression (overexpression) of neurokinin-1 receptor associated with substance p
9) Confidence 0.38 Published 2003 Journal Arch. Toxicol. Section Abstract Doc Link 13680092 Disease Relevance 0.51 Pain Relevance 0.84
Since RTX treatment does not alter NK-1 receptor expression, this reduced SP synthesis is likely to play a central role in the analgesic actions of RTX.
Neg (not) Regulation (alter) of Gene_expression (expression) of NK-1 receptor associated with analgesic and substance p
10) Confidence 0.36 Published 1999 Journal Brain Res. Section Abstract Doc Link 9878727 Disease Relevance 0 Pain Relevance 0.77
The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration.
Regulation (modulated) of in spinal cord Gene_expression (expression) of neurokinin receptor in ganglia associated with pain, opiate and spinal cord
11) Confidence 0.33 Published 1995 Journal Neuroscience Section Title Doc Link 7536308 Disease Relevance 0.40 Pain Relevance 0.95
The SP-induced changes of neurokinin-1 receptor expression in the cytosolic and membrane fractions
Regulation (changes) of Gene_expression (expression) of neurokinin-1 associated with substance p
12) Confidence 0.30 Published 2007 Journal Mol Pain Section Body Doc Link PMC2235838 Disease Relevance 0.40 Pain Relevance 0.63
In this study we investigated in the rat the long-term changes in NK-1r expression by spinoparabrachial LI neurons following the unilateral injection in the hindpaw plantar surface of complete Freund's adjuvant (CFA).
Spec (investigated) Regulation (changes) of Gene_expression (expression) of NK-1r in neurons
13) Confidence 0.27 Published 2009 Journal J. Comp. Neurol. Section Abstract Doc Link 19296480 Disease Relevance 0.31 Pain Relevance 0.46
Altered neurokinin-1 receptor gene expression provides a useful marker of long-term nociceptive activation and may mediate peripheral mechanisms of hyperalgesia and cellular sensitization during inflammation.
Regulation (Altered) of Gene_expression (expression) of neurokinin-1 receptor associated with nociception, hyperalgesia and inflammation
14) Confidence 0.27 Published 1999 Journal Neuroscience Section Abstract Doc Link 10430499 Disease Relevance 0.42 Pain Relevance 0.59
Addition of indomethacin to co-cultures inhibited the effect of FLS cells from acutely inflamed joints on neurokinin 1 receptor expression, suggesting an important role for prostaglandins.
Regulation (effect) of Gene_expression (expression) of neurokinin 1 receptor in joints
15) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860064 Disease Relevance 0.99 Pain Relevance 0.74
Lesions of the chorda tympani, which led to the degeneration of taste buds in fungiform papillae, had no effect on the immunohistochemical appearance of substance P in these papilla or on the substance P levels in the anterior part of the tongue.
Neg (no) Regulation (effect) of Gene_expression (appearance) of substance P in taste buds associated with substance p
16) Confidence 0.24 Published 1982 Journal Neuroscience Section Abstract Doc Link 6186943 Disease Relevance 0 Pain Relevance 0.55
Levels of substance P-like immunoreactivity (SP-LI) of the rat urinary bladder were unaffected up to 1 h from exposure to capsaicin (1 microM) in vitro.
Neg (unaffected) Regulation (unaffected) of Gene_expression (Levels) of substance P-like immunoreactivity in urinary bladder associated with qutenza and substance p
17) Confidence 0.24 Published 1987 Journal Brain Res. Section Abstract Doc Link 2449263 Disease Relevance 0 Pain Relevance 0.63
AIM: To evaluate the effect of capsaicin on substance P (SP) expression during induced inflammation in rat pulp tissue.
Regulation (effect) of Gene_expression (expression) of substance P associated with inflammation, qutenza and substance p
18) Confidence 0.24 Published 2005 Journal Int Endod J Section Abstract Doc Link 15606820 Disease Relevance 0.17 Pain Relevance 0.35
The effect of capsaicin on substance P expression in pulp tissue inflammation.
Regulation (effect) of Gene_expression (expression) of substance P associated with inflammation, qutenza and substance p
19) Confidence 0.24 Published 2005 Journal Int Endod J Section Title Doc Link 15606820 Disease Relevance 0.10 Pain Relevance 0.49
Soma areas for the retrogradely labelled cells that were NK1r-negative ranged between 137 and 1129 ?
Regulation (ranged) of Gene_expression (areas) of NK1r in Soma
20) Confidence 0.22 Published 2009 Journal Neuroscience Section Body Doc Link PMC2784948 Disease Relevance 0 Pain Relevance 0

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