INT88810

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 12.62
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF2) extracellular space (FGF2) extracellular region (FGF2)
nucleus (FGF2) cytoplasm (FGF2)
Anatomy Link Frequency
cartilage 6
macrophage 2
fibroblast 2
epithelial cells 2
eosinophil 2
FGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 91 99.44 Very High Very High Very High
cytokine 116 99.22 Very High Very High Very High
Angina 66 99.08 Very High Very High Very High
Inflammation 131 98.64 Very High Very High Very High
metalloproteinase 6 95.00 High High
Nicotine 79 92.32 High High
agonist 3 91.52 High High
antagonist 11 86.44 High High
Arthritis 26 82.04 Quite High
ischemia 17 77.76 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 17 100.00 Very High Very High Very High
Coronary Artery Disease 150 99.68 Very High Very High Very High
Eosinophilic Esophagitis 318 99.66 Very High Very High Very High
Apoptosis 45 99.56 Very High Very High Very High
Diabetes Mellitus 73 99.54 Very High Very High Very High
Rheumatoid Arthritis 95 99.44 Very High Very High Very High
Focal Cartilage Defect 9 99.32 Very High Very High Very High
Asthma 60 99.24 Very High Very High Very High
Cv General 3 Under Development 65 99.08 Very High Very High Very High
INFLAMMATION 128 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subjects were randomized 2:1 to a single dose of bFGF or placebo, injected into the left main coronary artery. bFGF doses ranged from 3 to 100 microg/kg, increasing in half-log increments. bFGF was generally well tolerated at doses of 3 to 30 microg/kg.
Positive_regulation (increasing) of Gene_expression (ranged) of bFGF in coronary artery
1) Confidence 0.50 Published 2000 Journal Am. J. Cardiol. Section Abstract Doc Link 10856385 Disease Relevance 0.73 Pain Relevance 0.25
The statistical analysis revealed a significant increase of the basal level expression for macrophage VEGF and bFGF in the CAD SA (stable angina) patient group compared to the noCAD (control) (p = 0.041 and p = 0.022 respectively) and CAD UA (unstable angina) (p = 0.024 and p = 0.005 respectively) groups, which was highly dependent on the diabetic status of the population.
Positive_regulation (increase) of Gene_expression (expression) of bFGF in macrophage associated with angina, coronary artery disease and diabetes mellitus
2) Confidence 0.40 Published 2003 Journal J Transl Med Section Abstract Doc Link PMC239962 Disease Relevance 1.19 Pain Relevance 0.19
Furthermore we demonstrated with an in vitro cell culture model that the short term effect of glucose and/or statins, which are usually observed in the diabetic CAD patients, did not increase the levels of VEGF and bFGF on monocytes from healthy donors.


Neg (not) Positive_regulation (increase) of Gene_expression (levels) of bFGF in monocytes associated with coronary artery disease and diabetes mellitus
3) Confidence 0.40 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.34 Pain Relevance 0.25
QT-PCR data showed that untreated EoE subjects had an increased expression of bFGF that was up to eight-fold higher (n = 35) compared to the HCs (n = 8, 1×, p < 0.05), and compared to when on treatment (n = 9 EoE subjects, 1.5×, p < 0.001).
Positive_regulation (increased) of Gene_expression (expression) of bFGF associated with eosinophilic esophagitis
4) Confidence 0.38 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.91 Pain Relevance 0
Among the four epidermal growth factors, 18 angiogenic genes and six cytokines, only seven genes (namely IL-8, VEGF, bFGF, angiopoietin 1, flt-1, Tie-2 and Tie-1) are overexpressed in WIBC-9 when compared with non-inflammatory models [37].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of bFGF associated with inflammation and cytokine
5) Confidence 0.38 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.27 Pain Relevance 0.20
In biopsies from asthmatic patients, Hoshino et al [52], showed higher expression of basic fibroblast growth factor (bFGF) and angiogenin, with significant correlations between the vascular area and the number of angiogenic factor-positive cells within the airways.
Positive_regulation (higher) of Gene_expression (expression) of bFGF in fibroblast associated with asthma
6) Confidence 0.35 Published 2010 Journal Respir Res Section Body Doc Link PMC2955663 Disease Relevance 0.41 Pain Relevance 0.17
PGE2 induced by COX-2 exerts several biological properties that may be advantageous for tumorigenesis: 1) Promoting angiogenesis (increased VEGF, bFGF, and PDGF production), 2) Anti-apoptosis mechanism (via increased bcl-2 and Akt activity), 3) Stimulating tumor metastasis (by increasing matrix metalloproteinases) and 4) Decreased immune surveillance (decreased cytokine production and NK activity).
Positive_regulation (increased) of Gene_expression (production) of bFGF associated with metalloproteinase, apoptosis, metastasis and cytokine
7) Confidence 0.31 Published 2004 Journal Front. Biosci. Section Abstract Doc Link 15353307 Disease Relevance 0.74 Pain Relevance 0.28
Extracts from ischemic rat brain have induced the production of BDNF, bFGF, VEGF and HGF in human MSCs in culture [73].
Positive_regulation (induced) of Gene_expression (production) of bFGF in HGF
8) Confidence 0.29 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.68 Pain Relevance 0.10
A recent study indicates that the expression of FGF2 by oral epithelial cells could be responsible for the vascularization of the cornea after ocular surface reconstruction using oral epithelial cells [35].
Positive_regulation (responsible) of Gene_expression (expression) of FGF2 in epithelial cells
9) Confidence 0.29 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0.25 Pain Relevance 0.04
PO disrupted bFGF-induced angiogenesis in CAM assay
Positive_regulation (induced) of Gene_expression (disrupted) of bFGF
10) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.17 Pain Relevance 0.03
The increased global expression of bFGF led to the investigation of the local expression bFGF of the esophageal biopsies of the subjects.
Positive_regulation (increased) of Gene_expression (expression) of bFGF
11) Confidence 0.27 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.67 Pain Relevance 0
The eosinophils may be operating in a positive feedback loop in which the expression bFGF is encouraging the increased activation of the eosinophil, which then leads to more bFGF expression and better chemotaxis.
Positive_regulation (leads) of Gene_expression (expression) of bFGF in eosinophil
12) Confidence 0.26 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.08 Pain Relevance 0
This might be explained as a consequence of the surgical manipulation of the cartilage defect boarder and the arthrotomy as it has been shown for bFGF, IGF-I or IL-1?
Positive_regulation (been) of Gene_expression (shown) of bFGF in cartilage associated with focal cartilage defect
13) Confidence 0.23 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.10 Pain Relevance 0.05
This might be explained as a consequence of the surgical manipulation of the cartilage defect boarder and the arthrotomy as it has been shown for bFGF, IGF-I or IL-1?
Positive_regulation (for) of Gene_expression (shown) of bFGF in cartilage associated with focal cartilage defect
14) Confidence 0.23 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.10 Pain Relevance 0.05
This might be explained as a consequence of the surgical manipulation of the cartilage defect boarder and the arthrotomy as it has been shown for bFGF, IGF-I or IL-1?
Positive_regulation (has) of Gene_expression (shown) of bFGF in cartilage associated with focal cartilage defect
15) Confidence 0.23 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.10 Pain Relevance 0.05
As demonstrated in Figure 7C, FGF-2 (10 ?
Positive_regulation (demonstrated) of Gene_expression (demonstrated) of FGF-2
16) Confidence 0.18 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.17 Pain Relevance 0
Furthermore, nAChR activation led to upregulation of VEGF-A and bFGF gene expression and enhanced hESC-EC survival and neovasculature formation after delivery in ischemic heart tissue.
Positive_regulation (upregulation) of Gene_expression (expression) of bFGF gene in heart
17) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 0.42 Pain Relevance 0.30
Early onset RA patients had significantly elevated synovial levels of IL-2, IL-4, IL-13, IL-17, EGF, and bFGF when compared with patients with established RA.
Positive_regulation (elevated) of Gene_expression (levels) of bFGF associated with rheumatoid arthritis
18) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.54 Pain Relevance 0.98
Since clinical introduction in the 1950s, ultrasound at intensities ranging from 1 to 50 mW/cm2 has been demonstrated to be osteogenic, chondrogenic, and angiogenic, thus accelerating skeletal healing in animal[10,11] and human clinical studies [1-3]In vitro cell-culture experiments have shown LIPUS upregulates osteoblastic production of IL-8, basic-FGF, VEGF, TGF-?
Positive_regulation (upregulates) of Gene_expression (production) of basic-FGF associated with osteoporosis
19) Confidence 0.01 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2414658 Disease Relevance 0.74 Pain Relevance 0.04

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