INT88820

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 5.48
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F3) aging (F3) cytoplasm (F3)
Anatomy Link Frequency
monocytes 8
macrophages 4
platelet 2
endothelial cells 1
endothelium 1
F3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 27 99.90 Very High Very High Very High
cva 1 97.24 Very High Very High Very High
Angina 6 86.00 High High
Inflammation 12 84.20 Quite High
aspirin 5 25.00 Low Low
cINOD 2 25.00 Low Low
ischemia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Versed 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerotic Plaque 4 99.48 Very High Very High Very High
Disseminated Intravascular Coagulation 25 97.80 Very High Very High Very High
Cv General 3 Under Development 7 97.24 Very High Very High Very High
Acute Coronary Syndrome 10 96.40 Very High Very High Very High
Rupture 4 96.20 Very High Very High Very High
Coagulation Disorder 3 95.84 Very High Very High Very High
Thrombosis 23 94.72 High High
Multiple Organ Failure 1 92.52 High High
Shock 5 91.44 High High
Sepsis 34 86.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Monocytes play an important role in the induction of tissue-factor expression 2, which is seen as a key event in the development of DIC in septic patients.
Positive_regulation (induction) of Gene_expression (expression) of tissue-factor in Monocytes associated with disseminated intravascular coagulation
1) Confidence 0.67 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1925152 Disease Relevance 1.22 Pain Relevance 0.05
Several mediators involved in the process of atherosclerotic plaque formation are capable of inducing tissue factor expression in cells such as monocytes, macrophages and endothelial cells, which under normal conditions do not express tissue factor or to a limited extent only.
Positive_regulation (inducing) of Gene_expression (expression) of tissue factor in macrophages associated with atherosclerotic plaque
2) Confidence 0.32 Published 2002 Journal Cardiovasc. Res. Section Abstract Doc Link 11827681 Disease Relevance 0.73 Pain Relevance 0.09
The increased expression of tissue factor is not limited to the plaque but is also found in circulating monocytes in patients with acute coronary syndromes.
Positive_regulation (increased) of Gene_expression (expression) of tissue factor in monocytes associated with acute coronary syndrome
3) Confidence 0.21 Published 2002 Journal Cardiovasc. Res. Section Abstract Doc Link 11827681 Disease Relevance 0.75 Pain Relevance 0.08
Several mediators involved in the process of atherosclerotic plaque formation are capable of inducing tissue factor expression in cells such as monocytes, macrophages and endothelial cells, which under normal conditions do not express tissue factor or to a limited extent only.
Positive_regulation (inducing) of in endothelial cells Gene_expression (expression) of tissue factor in macrophages associated with atherosclerotic plaque
4) Confidence 0.11 Published 2002 Journal Cardiovasc. Res. Section Abstract Doc Link 11827681 Disease Relevance 0.73 Pain Relevance 0.09
Several mediators involved in the process of atherosclerotic plaque formation are capable of inducing tissue factor expression in cells such as monocytes, macrophages and endothelial cells, which under normal conditions do not express tissue factor or to a limited extent only.
Positive_regulation (inducing) of in monocytes Gene_expression (expression) of tissue factor in macrophages associated with atherosclerotic plaque
5) Confidence 0.11 Published 2002 Journal Cardiovasc. Res. Section Abstract Doc Link 11827681 Disease Relevance 0.73 Pain Relevance 0.09
These cytokines can elicit Tissue Factor production on endothelium and monocytes.
Positive_regulation (elicit) of Gene_expression (production) of Tissue Factor in monocytes associated with cytokine
6) Confidence 0.01 Published 1999 Journal Baillieres Best Pract. Res. Clin. Haematol. Section Abstract Doc Link 10856974 Disease Relevance 0.63 Pain Relevance 0.35
The increase in platelet tissue factor expression 3.5 hr after UFP exposure (relative to baseline) approached significance [see Supplemental Material, Figure 2A (doi:10.1289/ehp.1002237)] (p = 0.07) and correlated strongly with the previously mentioned significant increases, at this time point, in expression of platelet CD40L (r = 0.91, p < 0.001).
Positive_regulation (increase) of Gene_expression (expression) of tissue factor in platelet
7) Confidence 0.00 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.05 Pain Relevance 0
These cytokines can elicit Tissue Factor production on endothelium and monocytes.
Positive_regulation (elicit) of in endothelium Gene_expression (production) of Tissue Factor in monocytes associated with cytokine
8) Confidence 0.00 Published 1999 Journal Baillieres Best Pract. Res. Clin. Haematol. Section Abstract Doc Link 10856974 Disease Relevance 0.63 Pain Relevance 0.35

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