INT88839

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Context Info
Confidence 0.35
First Reported 2000
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 2.47
Pain Relevance 6.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (St3gal3) Golgi apparatus (St3gal3)
Anatomy Link Frequency
spinal nerve 3
uterine 2
respiratory bronchioles 1
spinal cord 1
alveolar macrophages 1
St3gal3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 10 99.36 Very High Very High Very High
nociceptor 8 99.32 Very High Very High Very High
Spinal nerve ligature 9 99.12 Very High Very High Very High
Spinal cord 20 98.56 Very High Very High Very High
Root ganglion neuron 1 98.48 Very High Very High Very High
Peripheral nerve injury 6 98.24 Very High Very High Very High
c fibre 25 97.88 Very High Very High Very High
substance P 24 96.68 Very High Very High Very High
agonist 6 95.36 Very High Very High Very High
Dismenorea 3 94.88 High High
Disease Link Frequency Relevance Heat
Nociception 16 99.24 Very High Very High Very High
Ganglion Cysts 1 98.28 Very High Very High Very High
Nervous System Injury 9 98.24 Very High Very High Very High
Hypersensitivity 3 97.44 Very High Very High Very High
Dysmenorrhea 3 94.88 High High
Nicotine Addiction 3 63.76 Quite High
Heart Rate Under Development 1 48.24 Quite Low
Death 1 5.00 Very Low Very Low Very Low
Schizophrenia 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accompanying the loss of terminals and nicotinic binding sites were significant reductions in the expression of alpha 3, alpha 4, alpha 5, beta 2 and beta 4 nicotinic receptor subunits in the superficial layers of the spinal cord as determined by antibody staining and confocal microscopy.
Gene_expression (expression) of alpha 3 in spinal cord associated with spinal cord
1) Confidence 0.35 Published 2004 Journal J. Neurocytol. Section Abstract Doc Link 15906161 Disease Relevance 0.39 Pain Relevance 0.74
We designed a primer and probe for quantitating GlyR alpha 3 gene expression.
Gene_expression (expression) of GlyR alpha 3
2) Confidence 0.04 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2575349 Disease Relevance 0 Pain Relevance 0
After 1-day treatment with 17beta-estradiol, the decrease in the expression of alpha3 and beta1 without a change in Na+/K+-ATPase activity suggests that some isoform other than beta1 exist in rat uteri.
Gene_expression (expression) of alpha3
3) Confidence 0.04 Published 2000 Journal Chin J Physiol Section Abstract Doc Link 10857462 Disease Relevance 0.06 Pain Relevance 0.06
One day of E2 decreased both contraction frequency and alpha3-protein expression without the change in uterine diameter, enzyme activity or other isoforms.
Gene_expression (expression) of alpha3 in uterine
4) Confidence 0.04 Published 2000 Journal Chin J Physiol Section Abstract Doc Link 10857462 Disease Relevance 0.08 Pain Relevance 0.08
Thus the purpose of this study was to examine the correlation between estrogens-modulated uterine contraction and the expression of Na+/K+-ATPase alpha3 isoform in rats.
Gene_expression (expression) of alpha3 in uterine
5) Confidence 0.03 Published 2000 Journal Chin J Physiol Section Abstract Doc Link 10857462 Disease Relevance 0.09 Pain Relevance 0.09
In the dorsal spinal cord, confocal immunohistochemical microscopy revealed that nAChR subunits (alpha3, alpha4, alpha5, beta2 and beta4), NeuN B (neuronal marker) and NK1-r were all co-expressed in the superficial dorsal horn; however alpha3, alpha5, beta2 and beta4 exhibited the highest degree of colocalization with NK1-r expressing neurons.
Gene_expression (co-expressed) of alpha3 in dorsal horn associated with dorsal horn and spinal cord
6) Confidence 0.02 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18037142 Disease Relevance 0 Pain Relevance 0.75
We propose that the increased expression of the alpha3 and alpha5 nicotinic subunits may contribute to the mechanical hypersensitivity observed following spinal nerve ligation.
Gene_expression (expression) of alpha3 in spinal nerve associated with spinal nerve ligature and hypersensitivity
7) Confidence 0.02 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 14741388 Disease Relevance 0.45 Pain Relevance 0.54
We examined the expression of the alpha3, alpha4, alpha5, alpha7, beta2, beta3 and beta4 nicotinic subunits in the spinal cord of normal and spinal nerve ligated rats using immunocytochemistry.
Spec (examined) Gene_expression (expression) of alpha3 in spinal nerve associated with spinal cord
8) Confidence 0.02 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 14741388 Disease Relevance 0.43 Pain Relevance 0.52
The number of cells expressing the alpha3 subunit in the dorsal horn increased bilaterally following spinal nerve injury.
Gene_expression (expressing) of alpha3 in spinal nerve associated with nervous system injury and dorsal horn
9) Confidence 0.02 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 14741388 Disease Relevance 0.41 Pain Relevance 0.58
Alpha2, alpha3, alpha4, alpha5, alpha7, and beta2 subunits were detected at all levels of the intrapulmonary airways; including bronchi, terminal and respiratory bronchioles, alveolar walls, and alveolar macrophages.
Gene_expression (detected) of alpha3 in alveolar macrophages
10) Confidence 0.01 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19115400 Disease Relevance 0.06 Pain Relevance 0.95
Nicotinic acetylcholine receptors containing subunits alpha3 and alpha5 in rat nociceptive dorsal root ganglion neurons.
Gene_expression (containing) of alpha3 in dorsal root ganglion associated with ganglion cysts, nociception, nociceptor and root ganglion neuron
11) Confidence 0.01 Published 2006 Journal J. Mol. Neurosci. Section Title Doc Link 17192625 Disease Relevance 0.38 Pain Relevance 0.22
Alpha2, alpha3, alpha4, alpha5, alpha7, and beta2 subunits were detected at all levels of the intrapulmonary airways; including bronchi, terminal and respiratory bronchioles, alveolar walls, and alveolar macrophages.
Gene_expression (detected) of alpha3 in alveolar walls
12) Confidence 0.00 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19115400 Disease Relevance 0.06 Pain Relevance 0.95
Alpha2, alpha3, alpha4, alpha5, alpha7, and beta2 subunits were detected at all levels of the intrapulmonary airways; including bronchi, terminal and respiratory bronchioles, alveolar walls, and alveolar macrophages.
Gene_expression (detected) of alpha3 in respiratory bronchioles
13) Confidence 0.00 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19115400 Disease Relevance 0.06 Pain Relevance 0.95

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