INT88852

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Context Info
Confidence 0.65
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 28
Total Number 30
Disease Relevance 23.57
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleolus (Casp3) nucleus (Casp3) intracellular (Casp3)
Anatomy Link Frequency
cleavage 6
poly 3
neurons 2
brain 2
pancreatic islet 1
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 236 97.60 Very High Very High Very High
aspirin 15 95.48 Very High Very High Very High
Glutamate 146 93.96 High High
Arthritis 5 90.32 High High
Hippocampus 145 88.76 High High
cINOD 7 87.16 High High
local anesthetic 5 86.80 High High
antagonist 8 85.20 High High
metalloproteinase 7 84.64 Quite High
analgesia 1 81.72 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 567 99.96 Very High Very High Very High
Death 295 99.78 Very High Very High Very High
Diabetes Mellitus 393 99.20 Very High Very High Very High
Cancer 259 99.04 Very High Very High Very High
Stress 83 98.94 Very High Very High Very High
Hepatotoxicity 9 98.60 Very High Very High Very High
Ulcers 9 98.60 Very High Very High Very High
Cv Unclassified Under Development 196 97.60 Very High Very High Very High
Heart Disease 2 95.72 Very High Very High Very High
Hypoxia 105 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RT-PCR and Western blotting techniques were used to analyze mRNA and protein expression of HSP72 and HSP90 and cleavage of caspase 3 protein.
Protein_catabolism (cleavage) of caspase 3 in cleavage
1) Confidence 0.65 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10859212 Disease Relevance 0.75 Pain Relevance 0.30
The number of apoptotic cells, visualized with antibody against cleaved caspase-3, was increased in both ospemifene and tamoxifen-treated MIN-Os but the differences were not statistically significant (P = 0.198 and 0.4768 respectively, Fig. 3c).


Protein_catabolism (cleaved) of caspase-3 in apoptotic cells associated with cancer and apoptosis
2) Confidence 0.64 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.25 Pain Relevance 0
Ulcerated tissues were processed to assess ulcer area, malondialdehyde, proliferating cell nuclear antigen (PCNA) and cleaved caspase-3.
Protein_catabolism (cleaved) of caspase-3 associated with ulcers
3) Confidence 0.54 Published 2009 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18853145 Disease Relevance 0.84 Pain Relevance 0.15
The primary antibody was raised against amino acids 163 to 175 of murine caspase-3 and this neo-epitope is present on the p18 subunit of cleaved caspase-3.
Protein_catabolism (cleaved) of caspase-3
4) Confidence 0.52 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.60 Pain Relevance 0.26
Immunofluorescence analysis using the specific antibody against cleaved caspase-3 was performed at 10 d after surgery.
Protein_catabolism (cleaved) of caspase-3
5) Confidence 0.51 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2442085 Disease Relevance 0.10 Pain Relevance 0
Cleaved Caspase-3 is an important regulator of apoptosis and its proteolytically cleaved form is known to be upregulated in neurons undergoing apoptosis [44,45].
Protein_catabolism (Cleaved) of Caspase-3 in neurons associated with apoptosis
6) Confidence 0.51 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2442085 Disease Relevance 0.68 Pain Relevance 0
The levels of caspase-3 cleaved fragments were analyzed by Western blot.
Protein_catabolism (cleaved) of caspase-3
7) Confidence 0.41 Published 2008 Journal Am. J. Chin. Med. Section Abstract Doc Link 18711767 Disease Relevance 0.88 Pain Relevance 0.35
induced cleavage of caspase-3 and promoted apoptosis in cultured brain microvascular endothelial cells.
Protein_catabolism (cleavage) of caspase-3 in brain associated with apoptosis
8) Confidence 0.40 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.92 Pain Relevance 0.18
Indeed, our other results showed that cleaved caspase-3 was significantly decreased by PZH preventive treatment in ischemia (Figure 3).
Protein_catabolism (cleaved) of caspase-3 associated with ischemia
9) Confidence 0.34 Published 2010 Journal Chin Med Section Body Doc Link PMC2984508 Disease Relevance 1.39 Pain Relevance 0.19
Student's t-test was performed to evaluate the differences between groups for cell death assay and cleaved caspase-3 immunostaining results between the two SHRsp groups.
Protein_catabolism (cleaved) of caspase-3 associated with death
10) Confidence 0.34 Published 2010 Journal Chin Med Section Body Doc Link PMC2984508 Disease Relevance 0.33 Pain Relevance 0
Immunostaining for cleaved caspase-3
Protein_catabolism (cleaved) of caspase-3
11) Confidence 0.34 Published 2010 Journal Chin Med Section Body Doc Link PMC2984508 Disease Relevance 0.32 Pain Relevance 0.17
Specific caspase-3 activity was assessed using a caspase-3 assay, which could measure the cleavage of the caspase-3 specific substrate Ac-DEVD-pNA (Fig. 4).
Protein_catabolism (cleavage) of caspase-3 in cleavage
12) Confidence 0.27 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2089075 Disease Relevance 1.05 Pain Relevance 0
Conversely, caspase-3 is a protease that degrades the cell’s cytoskeleton during a phenomenon that is exclusively apoptotic [30,31].
Protein_catabolism (degrades) of caspase-3 associated with apoptosis
13) Confidence 0.26 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956113 Disease Relevance 0.65 Pain Relevance 0
Moreover, DMF+CCl(4) caused PARP cleavage and caspase-3 activation, but decreased the level of Bcl-xL, all of which confirmed apoptosis of hepatocytes.
Protein_catabolism (cleavage) of caspase-3 in hepatocytes associated with apoptosis
14) Confidence 0.26 Published 2010 Journal Chem. Biol. Interact. Section Abstract Doc Link 20097184 Disease Relevance 0.87 Pain Relevance 0.08
Specific caspase-3 activity was assessed using a caspase-3 assay, which could measure the cleavage of the caspase-3 specific substrate Ac-DEVD-pNA (Fig. 4).
Protein_catabolism (cleavage) of caspase-3 in cleavage
15) Confidence 0.24 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2089075 Disease Relevance 1.09 Pain Relevance 0
The protein-cleaving action of caspase-3 is important because blocking caspase-3 will reduce overall protein degradation in muscle [40].
Protein_catabolism (degradation) of caspase-3 in muscle
16) Confidence 0.20 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.77 Pain Relevance 0.11
However, McKinnon et al. [24] used antibodies from Idun Inc. and detected procaspase-3 and cleaved caspase-3.
Protein_catabolism (cleaved) of caspase-3
17) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.24 Pain Relevance 0
Cleaved caspase-3 was strongly present in the I/Ri group and iCORM-2 treated group, whereas caspase-3 cleavage was markedly inhibited in CORM-2 treated rats.
Protein_catabolism (cleavage) of caspase-3 in cleavage
18) Confidence 0.18 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.99 Pain Relevance 0
Apoptosis was accompanied by an increase in caspase-3 activity and cleavage of caspase-3 and poly(ADP-ribose) polymerase.
Protein_catabolism (cleavage) of caspase-3 in poly associated with apoptosis
19) Confidence 0.17 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11532860 Disease Relevance 1.45 Pain Relevance 0.34
To further support this possibility, we performed triple immunostaining against ChAT, p75 and p53 or cleaved caspase-3 in rat brain sections starting from day one up to two weeks after axotomy.
Protein_catabolism (cleaved) of caspase-3 in brain
20) Confidence 0.17 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.50 Pain Relevance 0.10

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