INT88855

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Context Info
Confidence 0.54
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.16
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90aa1) intracellular (Hsp90aa1) protein complex (Hsp90aa1)
cytoplasm (Hsp90aa1) cytosol (Hsp90aa1) protein folding (Hsp90aa1)
Anatomy Link Frequency
dorsal root ganglion 1
Hsp90aa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 12 100.00 Very High Very High Very High
Cannabinoid 2 100.00 Very High Very High Very High
Root ganglion neuron 2 97.72 Very High Very High Very High
aspirin 7 92.08 High High
Inflammation 3 85.36 High High
cINOD 1 80.56 Quite High
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 52 98.92 Very High Very High Very High
Ganglion Cysts 2 97.52 Very High Very High Very High
Shock 7 96.60 Very High Very High Very High
Apoptosis 6 95.76 Very High Very High Very High
Injury 7 88.32 High High
INFLAMMATION 4 85.36 High High
Nociception 4 83.68 Quite High
Pancreatitis 1 41.28 Quite Low
Ulcers 6 23.08 Low Low
Osteoporosis 2 21.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inversely, when ovariectomized female rats were treated with estrogen, the severity of the stress-induced gastric mucosal lesions was reduced with the recovered levels of HSP60, HSP70, and HSP90 in the gastric mucosa.
Negative_regulation (recovered) of HSP90 associated with stress
1) Confidence 0.54 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.73 Pain Relevance 0
HSP72 mRNA and protein expression was unchanged in adapted mucosa, whereas HSP90 mRNA and protein levels decreased.
Negative_regulation (decreased) of HSP90
2) Confidence 0.49 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10859212 Disease Relevance 0.76 Pain Relevance 0.32
HSP90 inhibitors alter capsaicin- and ATP-induced currents in rat dorsal root ganglion neurons.
Negative_regulation (inhibitors) of HSP90 in dorsal root ganglion associated with ganglion cysts, qutenza, cannabinoid and root ganglion neuron
3) Confidence 0.41 Published 2002 Journal Neuroreport Section Title Doc Link 11930156 Disease Relevance 0.34 Pain Relevance 0.64
In this study we demonstrate that inhibitors of HSP90 alter currents mediated by the ligand gated channels, P2X and VR1.
Negative_regulation (inhibitors) of HSP90
4) Confidence 0.41 Published 2002 Journal Neuroreport Section Abstract Doc Link 11930156 Disease Relevance 0.33 Pain Relevance 0.38

General Comments

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