INT88856

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Context Info
Confidence 0.39
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.31
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90aa1) intracellular (Hsp90aa1) protein complex (Hsp90aa1)
cytoplasm (Hsp90aa1) cytosol (Hsp90aa1) protein folding (Hsp90aa1)
Anatomy Link Frequency
cleavage 2
Hsp90aa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 7 97.84 Very High Very High Very High
cINOD 1 89.52 High High
fibrosis 2 87.92 High High
Inflammation 6 84.24 Quite High
cytokine 1 83.20 Quite High
alcohol 12 82.32 Quite High
Chronic pancreatitis 10 5.00 Very Low Very Low Very Low
Cholecystokinin 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 59 97.92 Very High Very High Very High
Apoptosis 13 97.12 Very High Very High Very High
Pancreatitis 48 91.52 High High
Injury 9 90.12 High High
INFLAMMATION 9 89.32 High High
Fibrosis 2 87.92 High High
Shock 6 76.20 Quite High
Alcoholic Pancreatitis 4 50.00 Quite Low
Ulcers 6 35.52 Quite Low
Osteoporosis 2 33.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, an ovariectomy reduced the expression of HSP60, HSP70, and HSP90 and significantly increased the severity of the WI-stress-induced gastric mucosal lesions in the female rats.
Negative_regulation (reduced) of Gene_expression (expression) of HSP90 associated with stress
1) Confidence 0.39 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.79 Pain Relevance 0
RT-PCR and Western blotting techniques were used to analyze mRNA and protein expression of HSP72 and HSP90 and cleavage of caspase 3 protein.
Spec (analyze) Negative_regulation (analyze) of Spec (analyze) Gene_expression (expression) of HSP90 in cleavage
2) Confidence 0.36 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10859212 Disease Relevance 0.75 Pain Relevance 0.28
Studying non-pancreatic tissues it was shown that quercetin inhibits synthesis of HSP110, HSp90, HSP40, and HSP28, in addition to HSP70.
Negative_regulation (inhibits) of Gene_expression (synthesis) of HSp90
3) Confidence 0.11 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872306 Disease Relevance 0.77 Pain Relevance 0.17

General Comments

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