INT88860

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.68
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hspa1a) mitochondrion (Hspa1a) nucleus (Hspa1a)
intracellular (Hspa1a) protein complex (Hspa1a) cytoplasm (Hspa1a)
Anatomy Link Frequency
arterioles 2
cleavage 2
body 2
Hspa1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 1 98.36 Very High Very High Very High
Spinal cord 41 97.72 Very High Very High Very High
ischemia 20 97.24 Very High Very High Very High
aspirin 7 96.84 Very High Very High Very High
cINOD 1 88.52 High High
Kinase C 1 71.48 Quite High
electroacupuncture 5 50.00 Quite Low
isoflurane 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 1 100.00 Very High Very High Very High
Apoptosis 6 98.16 Very High Very High Very High
Spinal Cord Ischemia 15 97.72 Very High Very High Very High
Reperfusion Injury 3 96.84 Very High Very High Very High
Stress 2 93.48 High High
Injury 13 92.70 High High
INFLAMMATION 2 88.32 High High
Death 2 77.24 Quite High
Frailty 6 70.24 Quite High
Pancreatitis 2 68.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to pharmacology of TMP and studies for effects of TMP on cerebral ischemic injury, antiplatelet activation and aggregation, dilating arterioles to improve microcirculation [17,18], scavenging free radicals, increasing the activity of SOD and decreasing lipid peroxidation [10], inhibiting calcium overload [9], reducing the production of nitric oxide and dynorphin A1-13 in ischemic tissue [19,20], decreasing the protein expression of c-fos and increasing the protein expression of bcl-2 and heat shock protein 70(HSP 70) [21,22]may be mechanisms for protection of TMP against spinal cord ischemia /reperfusion injury.
Positive_regulation (increasing) of Gene_expression (expression) of HSP 70 in arterioles associated with reperfusion injury, dynorphin, ischemia, shock, injury and spinal cord
1) Confidence 0.67 Published 2002 Journal BMC Neurol Section Body Doc Link PMC107739 Disease Relevance 0.86 Pain Relevance 0.41
RT-PCR and Western blotting techniques were used to analyze mRNA and protein expression of HSP72 and HSP90 and cleavage of caspase 3 protein.
Positive_regulation (cleavage) of Spec (analyze) Gene_expression (expression) of HSP72 in cleavage
2) Confidence 0.47 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10859212 Disease Relevance 0.75 Pain Relevance 0.30
RESULTS: EA significantly decreased the pancreatic weight/body weight ratio in CCK-induced acute pancreatitis, increased the pancreatic levels of HSP60 and HSP72, and decreased the beta-amylase and lipase levels associated with CCK-induced acute pancreatitis.
Positive_regulation (increased) of Gene_expression (levels) of HSP72 in body
3) Confidence 0.40 Published 2007 Journal Neuroimmunomodulation Section Body Doc Link 17804915 Disease Relevance 0.07 Pain Relevance 0

General Comments

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