INT88867

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Context Info
Confidence 0.62
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 28.31
Pain Relevance 3.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
MCs 2
skin 1
MCS (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 432 100.00 Very High Very High Very High
Inflammation 14 100.00 Very High Very High Very High
Endogenous opioid 1 100.00 Very High Very High Very High
Spinal cord 14 98.24 Very High Very High Very High
Pain 275 97.04 Very High Very High Very High
Somatostatin 2 96.04 Very High Very High Very High
medulla 1 95.80 Very High Very High Very High
cytokine 5 84.16 Quite High
Periaqueductal grey 1 79.44 Quite High
Anterior cingulate 1 77.56 Quite High
Disease Link Frequency Relevance Heat
Chronic Fatigue Syndrome 888 100.00 Very High Very High Very High
Sleep Disorders 432 100.00 Very High Very High Very High
Multiple Chemical Sensitivity 408 100.00 Very High Very High Very High
INFLAMMATION 19 100.00 Very High Very High Very High
Erythema 6 98.72 Very High Very High Very High
Pressure And Volume Under Development 4 98.32 Very High Very High Very High
Pruritus 6 97.40 Very High Very High Very High
Pain 223 97.04 Very High Very High Very High
Urological Neuroanatomy 2 95.96 Very High Very High Very High
Diabetes Mellitus 108 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mast cells (MCs), when activated, release a spectrum of mediators, among them histamine, which is involved in a variety of biological effects with clinical relevance, e.g. allergic hypersensitivity, itch, edema, local erythema and many types of dermatoses.
Localization (release) of MCs in MCs associated with pressure and volume under development, erythema, skin diseases, pruritus and hypersensitivity
1) Confidence 0.62 Published 2000 Journal Med. Hypotheses Section Abstract Doc Link 10859662 Disease Relevance 1.82 Pain Relevance 0.24
The release of inflammatory substances, such as histamine, from MCs in the skin results in a local erythema, edema and sensation of itch and pain, and the release of somatostatin from the dendritic cells may give rise to subjective sensations of on-going inflammation and sensitivity to ordinary light.
Localization (release) of MCs in skin associated with pain, pressure and volume under development, erythema, inflammation, pruritus and somatostatin
2) Confidence 0.62 Published 2000 Journal Med. Hypotheses Section Abstract Doc Link 10859662 Disease Relevance 1.93 Pain Relevance 0.32
Participants were categorized into four groups based on their diagnostic status of CFS alone; CFS and MCS (CFS-MCS); CFS and FM (CFS-FM); and CFS, MCS, and FM (CFS-MCS-FM).
Localization (status) of CFS-MCS-FM associated with multiple chemical sensitivity, chronic fatigue syndrome and fibrositis
3) Confidence 0.61 Published 2007 Journal Dyn Med Section Body Doc Link PMC1890280 Disease Relevance 3.55 Pain Relevance 0.44
No significant differences were found across diagnostic categories (CFS alone; CFS-MCS; CFS-FM; and CFS-MCS- FM) for the sociodemographic variables of race, marital status, gender, age, socioeconomic status, or whether or not an individual had children.
Localization (alone) of CFS-MCS associated with multiple chemical sensitivity, chronic fatigue syndrome and fibrositis
4) Confidence 0.61 Published 2007 Journal Dyn Med Section Body Doc Link PMC1890280 Disease Relevance 3.45 Pain Relevance 0.43
No significant differences were found across diagnostic categories (CFS alone; CFS-MCS; CFS-FM; and CFS-MCS- FM) for the sociodemographic variables of race, marital status, gender, age, socioeconomic status, or whether or not an individual had children.
Localization (alone) of CFS-MCS associated with multiple chemical sensitivity, chronic fatigue syndrome and fibrositis
5) Confidence 0.61 Published 2007 Journal Dyn Med Section Body Doc Link PMC1890280 Disease Relevance 3.45 Pain Relevance 0.43
Participants were categorized into four groups based on their diagnostic status of CFS alone; CFS and MCS (CFS-MCS); CFS and FM (CFS-FM); and CFS, MCS, and FM (CFS-MCS-FM).
Localization (status) of MCS associated with multiple chemical sensitivity, chronic fatigue syndrome and fibrositis
6) Confidence 0.61 Published 2007 Journal Dyn Med Section Body Doc Link PMC1890280 Disease Relevance 3.45 Pain Relevance 0.43
Participants were categorized into four groups based on their diagnostic status of CFS alone; CFS and MCS (CFS-MCS); CFS and FM (CFS-FM); and CFS, MCS, and FM (CFS-MCS-FM).
Localization (status) of CFS-MCS associated with multiple chemical sensitivity, chronic fatigue syndrome and fibrositis
7) Confidence 0.61 Published 2007 Journal Dyn Med Section Body Doc Link PMC1890280 Disease Relevance 3.47 Pain Relevance 0.43
Participants were categorized into four groups based on their diagnostic status of CFS alone; CFS and MCS (CFS-MCS); CFS and FM (CFS-FM); and CFS, MCS, and FM (CFS-MCS-FM).
Localization (status) of MCS associated with multiple chemical sensitivity, chronic fatigue syndrome and fibrositis
8) Confidence 0.61 Published 2007 Journal Dyn Med Section Body Doc Link PMC1890280 Disease Relevance 3.53 Pain Relevance 0.44
Recent evidence also points to a possible secretion of endogenous opioids triggered by chronic MCS.
Spec (possible) Localization (secretion) of MCS associated with endogenous opioid
9) Confidence 0.61 Published 2007 Journal Neuroimage Section Abstract Doc Link 17644413 Disease Relevance 0.45 Pain Relevance 0.66
The authors believe that developing stereotactic image guidance with such a navigation system could improve the success rate of MCS.


Localization (rate) of MCS
10) Confidence 0.61 Published 2001 Journal Neurosurg Focus Section Body Doc Link 16519423 Disease Relevance 0 Pain Relevance 0
Indeed, inappropriate targeting probably explains the reported variable success rate of MCS and certainly underestimates the actual efficacy.
Localization (rate) of MCS
11) Confidence 0.61 Published 2001 Journal Neurosurg Focus Section Body Doc Link 16519423 Disease Relevance 0 Pain Relevance 0
Activated MCs release a wide variety of bioactive mediators.
Localization (release) of MCs in MCs
12) Confidence 0.48 Published 2009 Journal Dig Dis Section Abstract Doc Link 20203509 Disease Relevance 0.19 Pain Relevance 0.04
Separate linear regression analyses were carried out for the PCS and MCS, which were treated as dependent variables.
Localization (treated) of MCS
13) Confidence 0.38 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2819993 Disease Relevance 0.56 Pain Relevance 0
In all cases of HLT and LLT in whom myocardial MCs were elevated, cardiomyocytic production of TNF-?
Localization (myocardial) of MCs
14) Confidence 0.33 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350147 Disease Relevance 0.24 Pain Relevance 0
The sections were counter-stained with light green in the case of MCs subtypes and C9, or MayerÂ’s Hematoxylin, for TNF-?
Localization (case) of MCs
15) Confidence 0.33 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350147 Disease Relevance 0.06 Pain Relevance 0
Seven of eight assessable cases of MCs (87.5%) showed a statistically significant increase in expression of eIF2?
Localization (cases) of MCs
16) Confidence 0.25 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.17 Pain Relevance 0
No significant associations were also observed between MCS and daily hours of TV/video watching except for T-3 and T-7, where an inverse association was observed.
Neg (except) Localization (observed) of MCS
17) Confidence 0.11 Published 2010 Journal Int J Behav Nutr Phys Act Section Body Doc Link PMC2996342 Disease Relevance 0 Pain Relevance 0
The results of the correlations between the individual items and two components of PCS and MCS are presented in Table 2.
Localization (presented) of MCS
18) Confidence 0.10 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2612648 Disease Relevance 0 Pain Relevance 0
Mean PCS and MCS scores obtained by using Turkish and US algorithms were also presented in Table 5.
Localization (presented) of MCS
19) Confidence 0.07 Published 2006 Journal BMC Public Health Section Body Doc Link PMC1615878 Disease Relevance 0.21 Pain Relevance 0
For both PCS and MCS, as household incomes decreased, respondentsÂ’ HRQoL decreased, such that those with incomes < $22,500 reported the greatest impact on HRQoL (p < 0.001 vs. ?
Localization (reported) of MCS
20) Confidence 0.04 Published 2008 Journal International Journal of Clinical Practice Section Body Doc Link PMC2423273 Disease Relevance 0.78 Pain Relevance 0

General Comments

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