INT88870

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.64
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDXP) plasma membrane (PDXP) cytoplasm (PDXP)
Anatomy Link Frequency
urine 1
PDXP (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 95.88 Very High Very High Very High
Neurotransmitter 4 91.20 High High
corticosteroid 1 79.36 Quite High
depression 1 77.60 Quite High
gABA 1 75.80 Quite High
Serotonin 8 75.44 Quite High
Arthritis 2 19.96 Low Low
Inflammation 2 18.84 Low Low
antidepressant 1 8.40 Low Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cervical Intraepithelial Neoplasia 17 100.00 Very High Very High Very High
Aging 25 99.16 Very High Very High Very High
Papillomavirus Infection 180 99.08 Very High Very High Very High
Pain 4 95.88 Very High Very High Very High
Hypertension 2 95.08 Very High Very High Very High
Lifespan 31 94.88 High High
Cancer 51 92.16 High High
Stress 26 91.88 High High
Injury 3 88.24 High High
Osteoporosis 1 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, physiological levels of PLP interact with glucocorticoid receptors to down-regulate their activity.
Negative_regulation (down-regulate) of PLP
1) Confidence 0.43 Published 2000 Journal Med. Hypotheses Section Abstract Doc Link 10859691 Disease Relevance 0.58 Pain Relevance 0.36
SQDB, GS, and CIN all significantly reduced levels of reactive oxygen species.
Negative_regulation (reduced) of CIN
2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2825258 Disease Relevance 1.29 Pain Relevance 0.04
In this group there was an 18% reduction in CIN 2/3 or AIS due to any HPV type.
Negative_regulation (reduction) of CIN associated with papillomavirus infection and cervical intraepithelial neoplasia
3) Confidence 0.02 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971720 Disease Relevance 2.02 Pain Relevance 0
Serum ALP doubled, and both urine PEA and serum PLP decreased.
Negative_regulation (decreased) of serum PLP in urine
4) Confidence 0.00 Published 2010 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 20089612 Disease Relevance 0.76 Pain Relevance 0.18

General Comments

This test has worked.

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