INT88873

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Context Info
Confidence 0.56
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 9.93
Pain Relevance 5.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
macrophages 5
RAW 264 3
A549 2
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 166 100.00 Very High Very High Very High
cytokine 11 100.00 Very High Very High Very High
chemokine 4 100.00 Very High Very High Very High
Paracetamol 19 99.98 Very High Very High Very High
tramadol 2 99.98 Very High Very High Very High
COX2 3 98.96 Very High Very High Very High
diclofenac 4 97.44 Very High Very High Very High
Analgesic 12 97.20 Very High Very High Very High
headache 2 97.08 Very High Very High Very High
aspirin 10 96.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 170 100.00 Very High Very High Very High
Cancer 160 100.00 Very High Very High Very High
Necrosis 11 100.00 Very High Very High Very High
Death 8 100.00 Very High Very High Very High
Myocardial Infarction 3 100.00 Very High Very High Very High
Adhesions 5 99.36 Very High Very High Very High
Headache 2 97.08 Very High Very High Very High
Common Cold 1 96.60 Very High Very High Very High
Neuralgia 1 96.08 Very High Very High Very High
Pressure And Volume Under Development 24 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that inhibiting nuclear factor-kappa B gene expression with nuclear factor-kappa B decoy may suppress inflammatory pain.
Negative_regulation (inhibiting) of Gene_expression (expression) of nuclear factor-kappa B
1) Confidence 0.56 Published 2006 Journal Spine Section Body Doc Link 17139220 Disease Relevance 0.08 Pain Relevance 0
B-p65 and -p50 expression after exposure in Ppar?
Negative_regulation (exposure) of Gene_expression (expression) of p50
2) Confidence 0.39 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.43 Pain Relevance 0.09
This was associated with decreased phosphorylation of NF-kappaB inhibitor protein, IkappaBalpha, and decreased expression of several NFkappaB-regulated genes.
Negative_regulation (decreased) of Gene_expression (expression) of NF-kappaB
3) Confidence 0.39 Published 2008 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 17473852 Disease Relevance 0.87 Pain Relevance 0.29
Total levels of the NF-kappaB inhibitor Ikappa-Balpha were reduced during exposure to VP-16.
Negative_regulation (reduced) of Gene_expression (levels) of NF-kappaB
4) Confidence 0.37 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11322928 Disease Relevance 0.12 Pain Relevance 0.03
Anti-inflammatory activities of ent-16alphaH,17-hydroxy-kauran-19-oic acid isolated from the roots of Siegesbeckia pubescens are due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB inactivation.
Negative_regulation (inactivation) of in macrophages Gene_expression (expression) of NF-kappaB in RAW 264 associated with inflammation and analgesic
5) Confidence 0.34 Published 2007 Journal Eur. J. Pharmacol. Section Title Doc Link 17207792 Disease Relevance 0.56 Pain Relevance 0.35
Anti-inflammatory activities of ent-16alphaH,17-hydroxy-kauran-19-oic acid isolated from the roots of Siegesbeckia pubescens are due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB inactivation.
Negative_regulation (inhibition) of Gene_expression (expression) of NF-kappaB in RAW 264 associated with inflammation and analgesic
6) Confidence 0.34 Published 2007 Journal Eur. J. Pharmacol. Section Title Doc Link 17207792 Disease Relevance 0.56 Pain Relevance 0.35
In constitutive NF-kappaB-expressing cells, treatment with P(3)-25 inhibited the expression of NF-kappaB-dependent reporter gene, adhesion molecules, and cyclooxygenase.
Negative_regulation (inhibited) of Gene_expression (expression) of NF-kappaB-dependent associated with adhesions
7) Confidence 0.32 Published 2007 Journal Cell Death Differ. Section Abstract Doc Link 16645640 Disease Relevance 0.45 Pain Relevance 0.09
Gold compounds have received great attention as an anti-inflammatory agents through their ability to inhibit expression of NF-kappa B and subsequent inflammatory reactions [6-8].
Negative_regulation (inhibit) of Gene_expression (expression) of NF-kappa B associated with inflammation
8) Confidence 0.25 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2914719 Disease Relevance 1.06 Pain Relevance 0.10
The expression levels of p65 and p50, as two subunits of NF-?
Negative_regulation (two) of Gene_expression (subunits) of p50
9) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.07 Pain Relevance 0
The expression levels of p65 and p50, as two subunits of NF-?
Negative_regulation (levels) of Gene_expression (subunits) of p50
10) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.12 Pain Relevance 0
The expression levels of p65 and p50, as two subunits of NF-?
Negative_regulation (levels) of Gene_expression (expression) of p50
11) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.12 Pain Relevance 0
The expression levels of p65 and p50, as two subunits of NF-?
Negative_regulation (levels) of Gene_expression (The) of p50
12) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.12 Pain Relevance 0
It was clearly evident from Western blot analysis of the total protein lysate derived from the dorsolateral prostate tissues with PIN lesions that expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, and BclII is down-regulated more effectively by celecoxib.
Negative_regulation (down-regulated) of Gene_expression (expression) of nuclear factor-kappaB
13) Confidence 0.21 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0 Pain Relevance 0
EMSA results showed that the NF-kappa B activation was not prevented by SB203580 in infected A549 cells, indicating that p38 MAPK and NF-kappa B are independent pathways regulating PGE2 expression in our experimental systems.
Negative_regulation (prevented) of Gene_expression (activation) of NF-kappa B in A549
14) Confidence 0.19 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 0.53 Pain Relevance 0
However, incubation of hepatic cells with salicylate, aspirin, indomethacin, ibuprofen, or 5,5-dimethyl-3(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone (DFU), a fluorinated derivative of rofecoxib, failed to impair IkappaB kinase activity, the processing of NF-kappaB, and the expression of NF-kappaB-dependent genes, such as NOS-2.
Negative_regulation (impair) of Gene_expression (expression) of NF-kappaB-dependent associated with aspirin
15) Confidence 0.14 Published 2002 Journal Hepatology Section Abstract Doc Link 11826407 Disease Relevance 0.50 Pain Relevance 0.61
Also, the ectopic expression of p65, which is a component of NF-kappaB, suppressed CRT.
Negative_regulation (suppressed) of Gene_expression (expression) of NF-kappaB
16) Confidence 0.11 Published 2005 Journal FEBS Lett. Section Abstract Doc Link 16051228 Disease Relevance 0.32 Pain Relevance 0.43
Ethyl acetate extract from Angelica Dahuricae Radix inhibits lipopolysaccharide-induced production of nitric oxide, prostaglandin E2 and tumor necrosis factor-alphavia mitogen-activated protein kinases and nuclear factor-kappaB in macrophages.
Negative_regulation (inhibits) of Gene_expression (production) of nuclear factor-kappaB in macrophages associated with necrosis, cancer and cox2
17) Confidence 0.11 Published 2007 Journal Pharmacol. Res. Section Title Doc Link 17229575 Disease Relevance 1.36 Pain Relevance 0.42
V-PYRRO/NO also suppressed the expression of acute phase protein genes and genes related to cell-death pathways, such as c-jun/AP-1, nuclear factor-kappaB, early response growth factor-1, heme oxygenase-1, caspase-3, growth arrest, and DNA-damaging protein-153.
Negative_regulation (suppressed) of Gene_expression (expression) of factor-kappaB associated with death
18) Confidence 0.10 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15010501 Disease Relevance 0.74 Pain Relevance 0.24
In endothelial cells, G2A expression blocks NF-kB activation and chemokine expression, thus inhibiting macrophage accumulation [45], which suggests that G2A expression may have a protective role for prevention of early events of inflammation.
Negative_regulation (blocks) of Gene_expression (expression) of NF-kB in macrophage associated with chemokine and inflammation
19) Confidence 0.09 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.95 Pain Relevance 0.64
Acetaminophen inhibited iNOS mRNA expression, promoter activity of iNOS gene and nuclear factor-kappa B (NF-kappaB) binding activity induced by LPS plus IFN-gamma, whereas salicylates did not show any effect on them.
Negative_regulation (inhibited) of Gene_expression (expression) of nuclear factor-kappa B associated with paracetamol
20) Confidence 0.08 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10860828 Disease Relevance 0.22 Pain Relevance 0.95

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