INT88878

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Context Info
Confidence 0.06
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Nfkb1, Nos2) cytosol (Nfkb1, Nos2) signal transduction (Nfkb1, Nos2)
nucleus (Nfkb1, Nos2) mitochondrion (Nfkb1) aging (Nos2)
Nfkb1 (Mus musculus)
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 4 99.56 Very High Very High Very High
Analgesic 2 99.14 Very High Very High Very High
Paracetamol 9 98.74 Very High Very High Very High
aspirin 3 88.36 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that acetaminophen may exert analgesic or anti-inflammatory effect by inhibiting iNOS expression induced by LPS plus IFN-gamma at transcriptional level by suppression of NF-kappaB binding activity, whereas salicylates exert its effect by inhibiting iNOS expression at the translational or posttranslational level.
Negative_regulation (suppression) of NF-kappaB Positive_regulation (induced) of Gene_expression (expression) of iNOS associated with paracetamol, inflammation and analgesic
1) Confidence 0.06 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10860828 Disease Relevance 0.10 Pain Relevance 0.81

General Comments

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