INT8890

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Context Info
Confidence 0.63
First Reported 1992
Last Reported 2009
Negated 0
Speculated 3
Reported most in Abstract
Documents 10
Total Number 13
Disease Relevance 4.02
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col1a1) extracellular region (Col1a1) proteinaceous extracellular matrix (Col1a1)
molecular_function (Col1a1) cytoplasm (Col1a1)
Anatomy Link Frequency
myocardium 1
osteoblasts 1
nucleus 1
osteocytes 1
annulus 1
Col1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 2 99.38 Very High Very High Very High
metalloproteinase 25 96.52 Very High Very High Very High
agonist 16 95.32 Very High Very High Very High
anesthesia 8 93.12 High High
Morphine 2 87.64 High High
fibrosis 8 86.44 High High
antagonist 5 83.76 Quite High
cerebral cortex 2 75.00 Quite High
opioid receptor 2 75.00 Quite High
Spinal cord 6 73.48 Quite High
Disease Link Frequency Relevance Heat
Overactive Bladder 6 99.52 Very High Very High Very High
Myocardial Infarction 50 95.68 Very High Very High Very High
Spinal Cord Injury 62 93.92 High High
Hypertension 4 93.12 High High
Intervertebral Disk Degeneration 117 90.64 High High
Infarction 31 90.48 High High
Fibrosis 9 86.44 High High
Hypertrophy 4 85.76 High High
Pressure Volume 2 Under Development 1 82.32 Quite High
Ataxia 1 80.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mRNA transcripts of type I collagen and osteocalcin were localized in osteoblasts and osteocytes, some of which expressed MMPs 2, 8, and 13.
Transcription (transcripts) of type I collagen in osteocytes associated with metalloproteinase
1) Confidence 0.63 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.36
Quantitative analysis and localization of mRNA transcripts of type I collagen, osteocalcin, MMP 2, MMP 8, and MMP 13 during bone healing in a rat calvarial experimental defect model.
Transcription (transcripts) of type I collagen
2) Confidence 0.63 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Title Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.31
Amlodipine, but not nifedipine, prevented an increase in the relative amount of V3 myosin heavy chain isoform and suppressed an increase in mRNA levels of beta-myosin heavy chain, skeletal alpha-actin, and type 1 collagen.
Transcription (levels) of type 1 collagen
3) Confidence 0.33 Published 1998 Journal Hypertension Section Abstract Doc Link 9449387 Disease Relevance 0.29 Pain Relevance 0.14
Mann found that presence of the T allele in the COLIA1 Sp1 binding site has functional effects on the collagen gene regulation that leads to a higher COLIA1 mRNA expression level, an increase COLIA1 protein expression level and COLIA1/COLIA2 protein ratios 25.
Transcription (expression) of COLIA1
4) Confidence 0.30 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.70 Pain Relevance 0
Mann found that presence of the T allele in the COLIA1 Sp1 binding site has functional effects on the collagen gene regulation that leads to a higher COLIA1 mRNA expression level, an increase COLIA1 protein expression level and COLIA1/COLIA2 protein ratios 25.
Transcription (expression) of COLIA1
5) Confidence 0.22 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.70 Pain Relevance 0
Mann found that presence of the T allele in the COLIA1 Sp1 binding site has functional effects on the collagen gene regulation that leads to a higher COLIA1 mRNA expression level, an increase COLIA1 protein expression level and COLIA1/COLIA2 protein ratios 25.
Transcription (expression) of COLIA1
6) Confidence 0.22 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.76 Pain Relevance 0
The mRNA transcripts of type I collagen and osteocalcin were localized in osteoblasts and osteocytes, some of which expressed MMPs 2, 8, and 13.
Transcription (transcripts) of type I collagen in osteoblasts associated with metalloproteinase
7) Confidence 0.21 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.36
This loss of compliance appears to be related to changes in composition of collagen type I and III within the detrusor tissue, shown by increased ratios of collagen type III/collagen type I mRNA transcripts within the detrusor tissue [3].
Transcription (transcripts) of collagen type I associated with overactive bladder
8) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 1.20 Pain Relevance 0.11
The effect of long term opioid treatment on the steady-state level of G-protein mRNA (G alpha s, G alpha i-1 and G alpha i-2) was analyzed using an RNAase protection hybridization assay.
Spec (analyzed) Transcription (level) of alpha i-1 associated with opioid
9) Confidence 0.06 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1382177 Disease Relevance 0 Pain Relevance 0.50
Loaded (c8-9) and internal-control discs (c6-7 and c10-11) were dissected and annulus and nucleus tissue were separately analyzed by real-time RT-PCR for levels of anabolic (collagen-1A1, collagen-2A1, aggrecan) and catabolic (MMP-3, MMP-13, ADAMTs-4) mRNA.
Spec (analyzed) Transcription (levels) of collagen-1A1 in nucleus
10) Confidence 0.06 Published 2004 Journal J. Orthop. Res. Section Abstract Doc Link 15475197 Disease Relevance 0 Pain Relevance 0.09
1 in infarcted (a) and noninfarcted (b) myocardium, and of collagen type I (c), type III (d), bFGF (e) and VEGF (f) mRNA expression in infarcted myocardium.
Transcription (expression) of collagen type I in myocardium
11) Confidence 0.05 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.37 Pain Relevance 0
No effects on the amounts of G alpha s mRNA, G alpha i-1 mRNA or G alpha i-2 mRNA were detected after 5 days of delta receptor stimulation.
Transcription (detected) of alpha i-1
12) Confidence 0.05 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1382177 Disease Relevance 0 Pain Relevance 0.52
Loaded (c8-9) and internal-control discs (c6-7 and c10-11) were dissected and annulus and nucleus tissue were separately analyzed by real-time RT-PCR for levels of anabolic (collagen-1A1, collagen-2A1, aggrecan) and catabolic (MMP-3, MMP-13, ADAMTs-4) mRNA.
Spec (analyzed) Transcription (levels) of collagen-1A1 in annulus
13) Confidence 0.02 Published 2004 Journal J. Orthop. Res. Section Abstract Doc Link 15475197 Disease Relevance 0 Pain Relevance 0.09

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