INT88917

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Context Info
Confidence 0.60
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 14.64
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp8) peptidase activity (Casp8) mitochondrion (Casp8)
nucleolus (Casp8) nucleus (Casp8) protein complex (Casp8)
Anatomy Link Frequency
myocytes 1
retinas 1
Semen 1
cleavage 1
RG2 1
Casp8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 46 98.08 Very High Very High Very High
ischemia 161 94.00 High High
Inflammation 27 93.52 High High
cytokine 58 92.48 High High
Hippocampus 16 88.40 High High
Chronic pancreatitis 1 81.92 Quite High
monoamine 9 70.96 Quite High
metalloproteinase 8 70.52 Quite High
fluoxetine 11 70.40 Quite High
sSRI 5 69.92 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 556 100.00 Very High Very High Very High
Death 242 100.00 Very High Very High Very High
Neurodegenerative Disease 16 100.00 Very High Very High Very High
Diabetes Mellitus 143 99.82 Very High Very High Very High
Stress 28 99.76 Very High Very High Very High
Alzheimer's Dementia 10 98.48 Very High Very High Very High
Primary Sclerosing Cholangitis 8 96.48 Very High Very High Very High
Cv Unclassified Under Development 111 94.00 High High
Necrosis 35 93.84 High High
INFLAMMATION 33 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondly, there is a path where receptors form groups in a death-receptor path, forming death-inducing signaling complex and finally activating the Casp8 and Casp3 (caspase-3) genes [23].
Positive_regulation (activating) of Casp8 associated with death
1) Confidence 0.60 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872860 Disease Relevance 1.05 Pain Relevance 0.08
However, in the Post group, unlike the Casp8 and the Casp4 gene expression in relation to apoptosis has increased.
Positive_regulation (increased) of Casp8 associated with apoptosis
2) Confidence 0.44 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872860 Disease Relevance 1.28 Pain Relevance 0.12
Surprisingly, unlike other antidepressants, we found that the standardized herbal medicine, Nelumbinis Semen, is free of factors that can induce neurodegenerative diseases such as caspase 8, ?
Positive_regulation (induce) of caspase 8 in Semen associated with antidepressant and neurodegenerative disease
3) Confidence 0.35 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC3009642 Disease Relevance 0.29 Pain Relevance 0.78
NE treatment increased caspase-9 activity to 197 +/- 62% over control myocytes (P < 0.0001), whereas no caspase-8 activation was detectable.
Neg (no) Positive_regulation (activation) of caspase-8 in myocytes
4) Confidence 0.27 Published 2000 Journal Anesthesiology Section Body Doc Link 10861165 Disease Relevance 0 Pain Relevance 0
Apoptosis was determined by TdT-UTP nick end-labeling reaction, annexin V binding, and caspase-8 activation.
Positive_regulation (activation) of caspase-8 associated with apoptosis
5) Confidence 0.18 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12181199 Disease Relevance 1.69 Pain Relevance 0.08
A previous report has demonstrated that translocation of FL-Bid to mitochondria may also occur in response to an activation of death receptors when caspase-8 activation is blocked by the addition of a caspase-8 inhibitor [43].
Positive_regulation (activation) of caspase-8 associated with death
6) Confidence 0.16 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.71 Pain Relevance 0.03
Once complexed, p55/TNFR1-TRADD may either facilitate apoptosis by activation of caspase-8 or enhance cell survival through disinhibition of the nuclear transcription factor, NF?
Positive_regulation (activation) of caspase-8 associated with apoptosis
7) Confidence 0.13 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.38 Pain Relevance 0.04
Certain steps in the cascade, such as the activation of caspase-8 to induce apoptosis and the release of NF?
Positive_regulation (activation) of caspase-8 associated with apoptosis
8) Confidence 0.13 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.47 Pain Relevance 0.09
Treatment with 1.25 µM Fe-SP revealed a similar result, with some activation of caspase-9, and -3, and inactivation of PARP-1 while the activation of caspase-8 was as strong as observed for 2.5 µM Fe-SP.
Positive_regulation (activation) of caspase-8
9) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386551 Disease Relevance 0.58 Pain Relevance 0
We observed strong cleavage/activation of initiator caspase-8, typical for the involvement of the extrinsic apoptotic pathway [27], [28], upon Fe-SP treatment of SKOV-3 cells.
Positive_regulation (activation) of caspase-8 in cleavage associated with apoptosis
10) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386551 Disease Relevance 0.96 Pain Relevance 0
Fe-SP treatment led to the activation of markers of the extrinsic (Caspase-8) and intrinsic (Caspase-9) pathway of apoptosis as well as of executioner Caspase-3 while PARP-1 was deactivated.
Positive_regulation (activation) of Caspase-8 associated with apoptosis
11) Confidence 0.10 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2386551 Disease Relevance 0.64 Pain Relevance 0
The activation of caspase 8 and caspase 3 in retinas of diabetic rats according to our results and the reduction of this activation by inhibition of TNF-?
Positive_regulation (activation) of caspase 8 in retinas associated with diabetes mellitus
12) Confidence 0.10 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2716944 Disease Relevance 1.38 Pain Relevance 0.04
The p75/TNFR2-TRADD construct is less stable than p55/TNFR1-TRADD and is considered to have a more focused role in cell survival by upregulating anti-apoptotic factors or preventing activation of caspase-8.
Positive_regulation (activation) of caspase-8 associated with apoptosis
13) Confidence 0.10 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.41 Pain Relevance 0.06
Caspase 8 is activated following death receptor clustering or integrin dysfunction and this is prevented by decoy proteins, the Fas-associated death-domain-like IL-1?
Positive_regulation (activated) of Caspase 8 associated with death
14) Confidence 0.07 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.84 Pain Relevance 0
The significant inhibition of the diabetes-induced activation of caspase 8 and 3 in our model leads to the conclusion that TNF-?
Positive_regulation (activation) of caspase 8 associated with diabetes mellitus
15) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2716944 Disease Relevance 1.66 Pain Relevance 0.03
Levels of caspase 8 in DBTRG-05MG and DBTRG 8401 were increased in a dose-dependent manner from 6 to 48 h after BP treatment, whereas the maximum expression of caspase 8 in RG2 cells at 24 h (Fig. 2d).
Positive_regulation (increased) of caspase 8 in RG2
16) Confidence 0.05 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.66 Pain Relevance 0
In addition, activation of death receptor-induced apoptosis-related caspase 8 protein was monitored.
Positive_regulation (activation) of caspase 8 associated with apoptosis and death
17) Confidence 0.04 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.59 Pain Relevance 0
Many signal transduction pathways such as Fas receptor-mediated signaling pathway via caspase-8, via activation of granzyme B, or the damage of mitochondria that results in cytochrome c release, have been implicated in the initiation of caspase-3 cascade [20-25].
Positive_regulation (activation) of caspase-8
18) Confidence 0.03 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 1.05 Pain Relevance 0.03

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