INT88935

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Context Info
Confidence 0.70
First Reported 2000
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 36
Total Number 38
Disease Relevance 31.07
Pain Relevance 5.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SPP1) extracellular region (SPP1) cell adhesion (SPP1)
cytoplasm (SPP1)
Anatomy Link Frequency
osteoblasts 3
epithelial cells 3
plasma 2
fibroblasts 2
lungs 2
SPP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 720 100.00 Very High Very High Very High
Inflammation 104 99.24 Very High Very High Very High
Chronic pancreatitis 13 98.68 Very High Very High Very High
Etanercept 14 98.24 Very High Very High Very High
Kinase C 5 96.24 Very High Very High Very High
Pain 33 95.36 Very High Very High Very High
Acupuncture 61 94.48 High High
COX2 2 94.28 High High
cytokine 64 89.88 High High
metalloproteinase 48 82.76 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 650 100.00 Very High Very High Very High
Cancer 477 100.00 Very High Very High Very High
Metastasis 453 100.00 Very High Very High Very High
Pancreatic Cancer 77 100.00 Very High Very High Very High
Adhesions 132 99.80 Very High Very High Very High
Internal Fibrosis 10 99.60 Very High Very High Very High
INFLAMMATION 98 99.24 Very High Very High Very High
Fibrosis 90 99.22 Very High Very High Very High
Osteoporosis 81 99.22 Very High Very High Very High
Nasopharynx Cancer 145 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Osteopontin influences the invasiveness of pancreatic cancer cells and is increased in neoplastic and inflammatory conditions.
Positive_regulation (increased) of Osteopontin associated with inflammation and pancreatic cancer
1) Confidence 0.70 Published 2005 Journal Cancer Biol. Ther. Section Title Doc Link 15970685 Disease Relevance 1.40 Pain Relevance 0.28
Osteopontin levels were increased more than 20-fold (mean expression 0.62 in control lungs, 16.8 in IPF lungs; Figure 1B).
Positive_regulation (increased) of Osteopontin in lungs associated with fibrosis
2) Confidence 0.69 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.56 Pain Relevance 0.28
Collectively, these results could indicate a mechanism by which osteopontin and MMP-7 are induced by aberrant activation of the WNT/?
Positive_regulation (induced) of osteopontin
3) Confidence 0.69 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.54 Pain Relevance 0.23
Our study confirms that upregulation of SPP1 is a feature intrinsic to androgen-resistant metastatic prostate cancer, independent of the site of metastasis.
Positive_regulation (upregulation) of SPP1 associated with prostate cancer and metastasis
4) Confidence 0.63 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 1.37 Pain Relevance 0.03
In agreement with this, the secreted phosphoprotein and cell adhesion molecule osteopontin (SPP1) is one of the most highly upregulated transcripts in our metastatic samples.
Positive_regulation (upregulated) of osteopontin associated with adhesions
5) Confidence 0.63 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 1.32 Pain Relevance 0
In agreement with this, the secreted phosphoprotein and cell adhesion molecule osteopontin (SPP1) is one of the most highly upregulated transcripts in our metastatic samples.
Positive_regulation (upregulated) of SPP1 associated with adhesions
6) Confidence 0.63 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 1.31 Pain Relevance 0
Elevated plasma osteopontin levels have also been correlated with lower survival and bone metastasis in hormone resistant prostate cancer [25].
Positive_regulation (Elevated) of osteopontin in plasma associated with prostate cancer and metastasis
7) Confidence 0.63 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 1.09 Pain Relevance 0
Several studies in experimental tissue fibrosis have suggested a possible profibrotic role of osteopontin.
Spec (possible) Positive_regulation (role) of osteopontin associated with fibrosis
8) Confidence 0.50 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.60 Pain Relevance 0.21
Osteopontin increases TIMP-1 expression by fibroblasts
Positive_regulation (increases) of Osteopontin in fibroblasts
9) Confidence 0.50 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0 Pain Relevance 0
Similarly, osteopontin is cleaved and activated by MMP-7 [31], and we observe that MMP-7 is induced by osteopontin in epithelial cells, suggesting that this positive feedback mechanism is also applicable to osteopontin and MMP-7.
Positive_regulation (activated) of osteopontin in epithelial cells
10) Confidence 0.50 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.81 Pain Relevance 0.37
To determine the effect of osteopontin on the growth rates of fibroblasts and epithelial cells, cells were stimulated with increasing concentrations of osteopontin, and the cell number was determined after 48 h using the cell proliferation reagent WST-1.
Positive_regulation (increasing) of osteopontin in fibroblasts
11) Confidence 0.46 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.46 Pain Relevance 0.23
Osteopontin expression levels were higher in most IPF lungs than in any control lung (Figure 1B).


Positive_regulation (higher) of Osteopontin in lung associated with fibrosis
12) Confidence 0.46 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.80 Pain Relevance 0.40
After 12 h, the medium was replaced by medium with 0.1% FBS alone or 0.1% FBS plus increasing concentrations of osteopontin (0.4, 1, and 2 ?
Positive_regulation (increasing) of osteopontin
13) Confidence 0.46 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0 Pain Relevance 0
Osteopontin was localized to alveolar epithelial cells in IPF lungs and was also significantly elevated in bronchoalveolar lavage from IPF patients.
Positive_regulation (elevated) of Osteopontin in epithelial cells associated with fibrosis
14) Confidence 0.46 Published 2005 Journal PLoS Medicine Section Abstract Doc Link PMC1198037 Disease Relevance 0.66 Pain Relevance 0.33
In this study, we tested the hypothesis that the disruption of bone homeostasis by tumor cells is due in part to the ability of tumor cells to upregulate osteopontin (OPN) mRNA in osteoblasts.
Positive_regulation (upregulate) of osteopontin in osteoblasts associated with cancer
15) Confidence 0.46 Published 2000 Journal J. Cell. Biochem. Section Abstract Doc Link 10861858 Disease Relevance 1.19 Pain Relevance 0.11
By real time quantitative PCR, there was a 2.2-fold and 1.6-fold increase of OPN mRNA in pancreatic cancers (n = 23) and chronic pancreatitis samples (n = 22), respectively, compared to normal pancreatic tissues (n = 20).
Positive_regulation (increase) of OPN associated with pancreatic cancer and chronic pancreatitis
16) Confidence 0.44 Published 2005 Journal Cancer Biol. Ther. Section Abstract Doc Link 15970685 Disease Relevance 1.48 Pain Relevance 0.31
Interestingly, Stanborough and collaborators also identified SPP1 as upregulated in their metastatic samples, however, their interpretation was that this increase was part of the bone response to the metastases.
Positive_regulation (upregulated) of SPP1 associated with metastasis
17) Confidence 0.43 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 1.22 Pain Relevance 0.03
SPP1 (osteopontin), a secreted, integrin-binding glycoprotein with adhesive properties, has been shown to be correlated with metastasis to the bone and with poor prognosis in various cancers and is highly upregulated in all the metastatic samples in our study.
Positive_regulation (upregulated) of osteopontin associated with cancer and metastasis
18) Confidence 0.43 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 1.17 Pain Relevance 0
SPP1 (osteopontin), a secreted, integrin-binding glycoprotein with adhesive properties, has been shown to be correlated with metastasis to the bone and with poor prognosis in various cancers and is highly upregulated in all the metastatic samples in our study.
Positive_regulation (upregulated) of SPP1 associated with cancer and metastasis
19) Confidence 0.43 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 1.17 Pain Relevance 0
In pancreatic cancer, Koopmann et al demonstrated that serum OPN levels were significantly elevated in patients with pancreatic adenocarcinoma prior to surgical resection compared to healthy controls.
Positive_regulation (elevated) of OPN associated with adenocarcinoma and pancreatic cancer
20) Confidence 0.42 Published 2009 Journal J Transl Med Section Body Doc Link PMC2796647 Disease Relevance 1.07 Pain Relevance 0.03

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