INT88947

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 2000
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 22
Total Number 25
Disease Relevance 7.00
Pain Relevance 4.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleolus (Pgr) nucleus (Pgr)
enzyme binding (Pgr) cytoplasm (Pgr)
Anatomy Link Frequency
brain 12
mammary gland 6
Visceral 2
hearts 2
preoptic area 2
Pgr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 113 99.98 Very High Very High Very High
amygdala 212 99.00 Very High Very High Very High
Potency 4 98.74 Very High Very High Very High
Enkephalin 2 98.72 Very High Very High Very High
antagonist 124 97.64 Very High Very High Very High
Dopamine 282 93.84 High High
anesthesia 25 93.12 High High
addiction 18 91.52 High High
Endogenous opioid 8 90.32 High High
Pain 19 88.32 High High
Disease Link Frequency Relevance Heat
Stress 60 100.00 Very High Very High Very High
Nociception 6 100.00 Very High Very High Very High
Cancer 380 98.32 Very High Very High Very High
Decapitation 15 94.80 High High
Colon Disease 1 94.76 High High
Breast Cancer 78 94.60 High High
Noninfiltrating Intraductal Carcinoma 2 94.32 High High
Ductal Carcinoma 2 92.48 High High
Targeted Disruption 29 88.80 High High
Pain 15 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The tumor was highly positive for estrogen receptor (ER) expression (95%), but less than 10% positive for progesterone receptor (PR) expression.
Positive_regulation (positive) of Gene_expression (expression) of PR associated with cancer
1) Confidence 0.64 Published 2008 Journal Cases J Section Body Doc Link PMC2565669 Disease Relevance 1.39 Pain Relevance 0.10
The potency of Group A compounds, but not Group B or C compounds, for ECG actions indicative of Na(+) channel blockade (prolongation of PR and QRS intervals) were significantly increased under "simulated ischaemic" conditions ([K(+)] 10 mM and pH 6.4) in isolated rat hearts.
Positive_regulation (increased) of Gene_expression (actions) of PR in hearts associated with potency
2) Confidence 0.48 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10862826 Disease Relevance 0.15 Pain Relevance 0.12
The tumor was highly positive for estrogen receptor (ER) expression (95%), but less than 10% positive for progesterone receptor (PR) expression.
Positive_regulation (positive) of Gene_expression (expression) of progesterone receptor associated with cancer
3) Confidence 0.46 Published 2008 Journal Cases J Section Body Doc Link PMC2565669 Disease Relevance 1.39 Pain Relevance 0.10
The endocrine disrupters butyl benzyl phthalate and bisphenol A increase the expression of progesterone receptor messenger ribonucleic acid in the preoptic area of adult ovariectomized rats.
Positive_regulation (increase) of Gene_expression (expression) of progesterone receptor in preoptic area associated with enkephalin
4) Confidence 0.42 Published 2001 Journal Neuroendocrinology Section Title Doc Link 11474214 Disease Relevance 0 Pain Relevance 0.20
Therefore, we performed proliferation-specific analyses and determined expression of the progesterone receptor (PR), which is stimulated in the mammary gland after E2 exposure (Tekmal et al. 2005).
Positive_regulation (stimulated) of Spec (determined) Gene_expression (expression) of PR in mammary gland
5) Confidence 0.39 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.23 Pain Relevance 0.17
In agreement with our data, they observed estrogenic effects of GEN in the mammary gland (PR expression was increased) and a mild uterotrophic effect of GEN.
Positive_regulation (increased) of Gene_expression (expression) of PR in mammary gland
6) Confidence 0.39 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.09 Pain Relevance 0
Concomitant with the increased activity of the Raf/Ras/MAPK cascade, we found a significant increase in the expression of the PR in mammary tissues from IGF-I-treated parous rats.
Positive_regulation (increase) of Gene_expression (expression) of PR
7) Confidence 0.34 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.29 Pain Relevance 0
Therefore, we performed proliferation-specific analyses and determined expression of the progesterone receptor (PR), which is stimulated in the mammary gland after E2 exposure (Tekmal et al. 2005).
Positive_regulation (stimulated) of Spec (determined) Gene_expression (expression) of progesterone receptor in mammary gland
8) Confidence 0.28 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.23 Pain Relevance 0.17
We conducted pilot studies that confirm that the dose of PSK 3668 used in these experiments does not increase PR expression, a marker of ER activity, within the developing brain.
Neg (not) Positive_regulation (increase) of Gene_expression (expression) of PR in brain
9) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0.06 Pain Relevance 0.27
g 2 h prior to estradiol treatment was sufficient to block estradiol-induced PR expression in the neonatal female rat brain.
Positive_regulation (induced) of Gene_expression (expression) of PR in brain
10) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0.07 Pain Relevance 0.31
, while significantly increasing the expression of the PR and pS2 – an activity that is blocked with antiestrogen [55,56].
Positive_regulation (increasing) of Gene_expression (expression) of PR
11) Confidence 0.25 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.32 Pain Relevance 0
Therefore, the effects of IGF-I on PR expression may differ depending on whether they are achieved through stimulating ER-?
Positive_regulation (on) of Gene_expression (expression) of PR
12) Confidence 0.25 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.19 Pain Relevance 0
Therefore, the effects of IGF-I on PR expression may differ depending on whether they are achieved through stimulating ER-?
Positive_regulation (depending) of Gene_expression (expression) of PR
13) Confidence 0.25 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.19 Pain Relevance 0
Those investigators showed that the phosphatidylinositol 3-kinase (PI3-K)/Act pathway was involved in regulating the enhanced PR expression.
Positive_regulation (enhanced) of Gene_expression (expression) of PR
14) Confidence 0.25 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.28 Pain Relevance 0
Like phosphorylation of ERK1/2, the expression of PR in mammary tissues was significantly elevated in animals treated with IGF-I, but PR expression was lowest in untreated parous animals (Fig. 9).
Positive_regulation (elevated) of Gene_expression (expression) of PR
15) Confidence 0.23 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.07 Pain Relevance 0
Experimental evidence found that A. castus demonstrates a significant competitive binding to estrogen receptors alpha (ER alpha) and beta (ER beta) as well as stimulating Progesterone Receptor expression (25).
Positive_regulation (stimulating) of Gene_expression (expression) of Progesterone Receptor
16) Confidence 0.20 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529385 Disease Relevance 0.40 Pain Relevance 0.36
PSK 3668 administered systemically blocks ER binding [33] and ER-induced PR expression [34] in the adult rat brain, as well as female sexual behavior [32].
Positive_regulation (induced) of Gene_expression (expression) of PR in brain
17) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0.05 Pain Relevance 0.27
Interestingly, neonatal treatment with the D1-like agonist increased PR expression only within the central amygdala (CeA) and the bed nucleus of the stria terminalis (BST) of the developing female rat brain and these increases were blocked by an ER antagonist [15], which is consistent with PR dependence upon ER expression in developing brain [16].
Positive_regulation (increased) of Gene_expression (expression) of PR in brain associated with addiction, antagonist, agonist and amygdala
18) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0 Pain Relevance 0.67
In addition to masculinizing the development of social play, dopaminergic activation of ERs also increases the expression of the ER-dependent progestin receptor (PR) within restricted brain regions.
Positive_regulation (increases) of Gene_expression (expression) of PR in brain
19) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0 Pain Relevance 0.64
This dose of SKF 38393 has been previously shown to activate ERs within the developing rat brain to increase PR expression and social play behavior [15].
Positive_regulation (increase) of Gene_expression (expression) of PR in brain
20) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0.09 Pain Relevance 0.52

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox