INT88948

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2000
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 9.18
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Anatomy Link Frequency
macrophage 1
endothelial cells 1
liver 1
colon 1
vessels 1
Ace (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 9 99.90 Very High Very High Very High
Inflammation 14 99.72 Very High Very High Very High
cytokine 2 99.20 Very High Very High Very High
Neuritis 1 97.76 Very High Very High Very High
Multiple sclerosis 3 96.08 Very High Very High Very High
Peripheral nervous system 4 91.84 High High
Demyelination 1 64.88 Quite High
antagonist 7 60.68 Quite High
Potency 2 35.28 Quite Low
COX-2 inhibitor 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Left Ventricular Dysfunction 4 100.00 Very High Very High Very High
Metastasis 240 99.96 Very High Very High Very High
Colon Cancer 249 99.74 Very High Very High Very High
INFLAMMATION 16 99.72 Very High Very High Very High
Proteinuria 18 99.70 Very High Very High Very High
Cancer 233 99.30 Very High Very High Very High
Fibrosis 7 98.84 Very High Very High Very High
Coronary Heart Disease 9 98.68 Very High Very High Very High
Neuritis 1 97.76 Very High Very High Very High
Stress 3 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The macrophage product angiotensin converting enzyme (ACE) is released during inflammation.
Localization (eleased ) of ACE in macrophage associated with inflammation
1) Confidence 0.69 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10863022 Disease Relevance 1.11 Pain Relevance 0.61
Despite the seemingly valid rationale for the trandolapril dosing, some critics have hypothesized that patients with stable coronary disease and preserved left ventricular function may need higher doses of ACE inhibitor than those with left ventricular dysfunction, as the latter group has increased secretion of growth factors, cytokines, signaling pathways and neurohormones (Pitt 2004).
Localization (secretion) of ACE associated with left ventricular dysfunction, coronary heart disease and cytokine
2) Confidence 0.65 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.38 Pain Relevance 0.05
In the normal liver adjacent to CRC metastases, ACE localized to the hepatic endothelial cells of liver veins and some sinusoidal endothelial cells in both sham operated animals and in tumor-bearing control and captopril treated animals.
Localization (localized) of ACE in liver associated with cancer, colon cancer and metastasis
3) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.13 Pain Relevance 0
Cell counts were performed on day 16 and 21 tumors, but not in the adjacent liver as ACE positive staining localized to non-sinusoidal endothelial cells in all treatments and conditions and differences in staining intensity could not be assessed with the antibody used.


Localization (localized) of ACE in endothelial cells associated with cancer
4) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 0.67 Pain Relevance 0
Immunohistochemical staining for ACE localized this protein to the stromal desmoplasia surrounding angiogenic vessels in CRC metastases (Figure 3).
Localization (localized) of ACE in vessels associated with fibrosis, colon cancer and metastasis
5) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.22 Pain Relevance 0
Thus, combination therapy with NSAIDs and ACE inhibitors targeting IGF-IR might be a novel and potentially promising strategy for the chemoprevention of colon cancer.
Localization (targeting) of ACE in colon associated with colon cancer and cinod
6) Confidence 0.51 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14583467 Disease Relevance 0.31 Pain Relevance 0.39
We found ACE (kininase II) present in the human placenta [20, 21] and showed that maternal serum ACE activity did not change in preeclampsia compared with normal pregnancy [19].
Localization (found) of kininase II in placenta associated with pre-eclampsia
7) Confidence 0.25 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.62 Pain Relevance 0
secreted intothe systemic circulation and cleaved by REN and ACE to
Localization (secreted) of ACE
8) Confidence 0.12 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0.80 Pain Relevance 0.06
These patients were treated with MMF (mean dose 1173 mg daily) and prednisolone (mean dose 31 mg daily), in addition to other measures to reduce proteinuria (including an ACE inhibitor and/or anigotensin receptor blocker).
Localization (blocker) of ACE associated with proteinuria
9) Confidence 0.10 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721349 Disease Relevance 0.88 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox