INT88949

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Context Info
Confidence 0.60
First Reported 2000
Last Reported 2011
Negated 6
Speculated 1
Reported most in Abstract
Documents 79
Total Number 80
Disease Relevance 47.68
Pain Relevance 19.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12a) extracellular region (Il12a) cytoplasm (Il12a)
Anatomy Link Frequency
macrophages 7
lung 6
T-cells 3
spleen 2
peritoneal macrophages 2
Il12a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1379 100.00 Very High Very High Very High
Inflammation 867 100.00 Very High Very High Very High
Morphine 60 99.98 Very High Very High Very High
withdrawal 48 99.80 Very High Very High Very High
Peripheral nervous system 4 99.76 Very High Very High Very High
Paracetamol 15 99.68 Very High Very High Very High
chemokine 100 99.42 Very High Very High Very High
agonist 88 99.28 Very High Very High Very High
Clonidine 1 99.08 Very High Very High Very High
Catecholamine 1 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 957 100.00 Very High Very High Very High
Infection 1815 99.96 Very High Very High Very High
Mycobacterial Infection 84 99.96 Very High Very High Very High
Splenomegaly 14 99.90 Very High Very High Very High
Targeted Disruption 137 99.88 Very High Very High Very High
Influenza Virus Infection 130 99.84 Very High Very High Very High
Disease 640 99.76 Very High Very High Very High
Cold Sores 1298 99.72 Very High Very High Very High
Candida Infection 151 99.52 Very High Very High Very High
Injury 78 99.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The enhancement of IL-12 by morphine might be related to morphine-induced sepsis.
Positive_regulation (enhancement) of IL-12 associated with sepsis and morphine
1) Confidence 0.60 Published 2000 Journal J. Leukoc. Biol. Section Abstract Doc Link 11073113 Disease Relevance 0.33 Pain Relevance 0.99
After 2 h of intratracheal administration of tIL-12 or non-transgenic control extracts, mice lungs showed occasional patches of eosinophilic fibrilar material into alveolar spaces with few neutrophils (Figure 2A), while no significant histological changes were seen in mice that received rIL-12.
Positive_regulation (received) of rIL-12 in lungs associated with targeted disruption and rhinitis
2) Confidence 0.50 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2888828 Disease Relevance 0.68 Pain Relevance 0.12
However, RU486 did not restore IFN-alpha or IL-12.
Neg (not) Positive_regulation (restore) of IL-12
3) Confidence 0.49 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 15589048 Disease Relevance 0.25 Pain Relevance 0.44
Our results clearly indicate that plant-expressed IL-12, like recombinant IL-12, was successfully delivered to the lungs, as observed by the IL-12 increase in mice treated with tomato fruit crude extracts or recombinant IL-12.
Positive_regulation (increase) of IL-12 in lungs
4) Confidence 0.47 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2888828 Disease Relevance 0.37 Pain Relevance 0
However, lung levels of the chemokine, eotaxin, and the cytokine, IL-12, were significantly elevated in the acetaminophen challenged animals that were fed, but not in the fasted group.
Neg (not) Positive_regulation (elevated) of IL-12 in lung associated with chemokine, paracetamol and cytokine
5) Confidence 0.46 Published 2003 Journal Exp. Mol. Pathol. Section Abstract Doc Link 14611809 Disease Relevance 0.76 Pain Relevance 0.95
This study was designed to determine if alpha(2)-adrenoceptor agonists are involved in the induction of interleukin-12 production by macrophages. alpha(2)-adrenoceptor agonists such as clonidine, guanfacine, and oxymetazoline significantly induced interleukin-12 secretion and interleukin-12 mRNA expression by macrophages in a concentration-dependent manner.
Positive_regulation (induced) of interleukin-12 in macrophages associated with agonist and clonidine
6) Confidence 0.46 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.42
ELISA data showed that both IL-12 p40 and p70 were increased by morphine.
Positive_regulation (increased) of IL-12 associated with morphine
7) Confidence 0.44 Published 2000 Journal J. Leukoc. Biol. Section Abstract Doc Link 11073113 Disease Relevance 0.26 Pain Relevance 1.09
Morphine enhances interleukin-12 and the production of other pro-inflammatory cytokines in mouse peritoneal macrophages.
Positive_regulation (enhances) of interleukin-12 in peritoneal macrophages associated with inflammation, cytokine and morphine
8) Confidence 0.44 Published 2000 Journal J. Leukoc. Biol. Section Title Doc Link 11073113 Disease Relevance 0.23 Pain Relevance 0.82
The enhancement of IL-12 at both the mRNA and protein levels was antagonized by naltrexone, indicating that the modulation of this cytokine by morphine is via a classic opioid receptor.
Positive_regulation (enhancement) of IL-12 associated with opioid receptor, morphine and cytokine
9) Confidence 0.44 Published 2000 Journal J. Leukoc. Biol. Section Abstract Doc Link 11073113 Disease Relevance 0.26 Pain Relevance 1.10
Additional studies are being performed which address whether PTU treatment of patients with plaque psoriasis leads to reduced in situ IL-12 expression, alters production of the IL-35 or IL-40 components of the IL-70 heterodimer, as well as exerts an effect by enhancing apoptosis in the proliferated keratinocytes that make up the psoriatic plaque which would result in clinical improvement.


Positive_regulation (components) of IL-35 in keratinocytes associated with psoriasis and apoptosis
10) Confidence 0.44 Published 2003 Journal BMC Dermatol Section Body Doc Link PMC169161 Disease Relevance 0.53 Pain Relevance 0.21
Significantly, elevated levels of colonic RNA for pro-inflammatory cytokines interleukin (IL)-6 and IL-12 were also decreased toward normal with NTX.
Positive_regulation (elevated) of IL-12 associated with inflammation and cytokine
11) Confidence 0.40 Published 2008 Journal J Immunotoxicol Section Abstract Doc Link 18569389 Disease Relevance 1.74 Pain Relevance 0.78
A collaborative action of dendritic cells and macrophages could be important, as indicated for IL-12 induction by influenza virus and other inducers [241].
Positive_regulation (induction) of IL-12 in macrophages associated with influenza virus infection
12) Confidence 0.36 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.27 Pain Relevance 0
Important mediators of this embankment are IL-4 and IL-13, which as described above repress the induction of IL-12, and thus put a brake on the positive feed-back loop of IFN-?
Positive_regulation (induction) of IL-12
13) Confidence 0.36 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.34 Pain Relevance 0.31
The IL-12 induction during HSV infection requires infectious virus, and it was shown to be regulated at the transcriptional level [238], as it is also the case when it is induced by LPS [247,367].
Positive_regulation (induction) of IL-12 associated with cold sores and infection
14) Confidence 0.36 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 1.22 Pain Relevance 0.13
[249-251].The Th2 cytokines of the other side of the adaptive response, IL-4 and IL-13, inhibit IL-12 induction in the early phases of stimulation, but later they can be potent inducers of IL-12 production, although they still inhibit many of the IFN-?
Positive_regulation (induction) of IL-12 associated with cytokine
15) Confidence 0.36 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.30 Pain Relevance 0.20
Spleen cells from mice undergoing withdrawal also had decreased splenic mRNA and/or protein levels of IL-1beta, IL-1Ra, TNF-alpha, IL-12, and IFN-gamma.
Positive_regulation (levels) of IL-12 in Spleen associated with withdrawal
16) Confidence 0.33 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 14597094 Disease Relevance 0 Pain Relevance 0.49
Protein kinase A activation then prevents the phosphorylation and subsequent degradation of IkappaB, which in turn prevents translocation of the NF-kappaB p65 subunit to the nucleus to transactivate the IL-12 p40 gene, ultimately resulting in decreased IL-12 production following LPS stimulation.
Positive_regulation (transactivate) of IL-12 in nucleus
17) Confidence 0.32 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18322172 Disease Relevance 0 Pain Relevance 0.77
Morphine withdrawal inhibits IL-12 induction in a macrophage cell line through a mechanism that involves cAMP.
Positive_regulation (induction) of IL-12 in macrophage associated with withdrawal and morphine
18) Confidence 0.32 Published 2008 Journal J. Immunol. Section Title Doc Link 18322172 Disease Relevance 0 Pain Relevance 0.86
Another approach is to use natural up-regulators to elevate endogenous levels of IL-12 or IFN-?.
Positive_regulation (elevate) of IL-12
19) Confidence 0.32 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.65 Pain Relevance 0.19
However, the relative contributions of IL-12 and IL-23 to the pathogenic process remain to be elucidated.
Positive_regulation (contributions) of IL-12
20) Confidence 0.32 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2442630 Disease Relevance 0.40 Pain Relevance 0.18

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