INT88957

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Context Info
Confidence 0.42
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 7.34
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (VWF) cell adhesion (VWF) endoplasmic reticulum (VWF)
proteinaceous extracellular matrix (VWF)
Anatomy Link Frequency
endothelial cells 4
plasma 2
tube 2
blood 2
platelet 2
VWF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 126 99.56 Very High Very High Very High
agonist 3 96.60 Very High Very High Very High
abdominal pain 2 90.04 High High
Inflammatory response 21 83.84 Quite High
cytokine 26 80.88 Quite High
Arthritis 1 71.12 Quite High
metalloproteinase 15 66.80 Quite High
Migraine 6 50.00 Quite Low
Angina 26 29.08 Quite Low
ischemia 30 20.24 Low Low
Disease Link Frequency Relevance Heat
Adhesions 55 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 69 99.96 Very High Very High Very High
INFLAMMATION 160 99.92 Very High Very High Very High
Congenital Anomalies 13 98.52 Very High Very High Very High
Diabetes Mellitus 303 97.36 Very High Very High Very High
Thrombosis 16 96.64 Very High Very High Very High
Renal Disease 6 96.04 Very High Very High Very High
Hypoalbuminemia 1 95.96 Very High Very High Very High
Atherosclerosis 93 95.20 Very High Very High Very High
Thrombophilia 4 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased circulating levels of vWF, PAI-1, t-PA, TFPI, and s-TM have been reported in patients with NIDDM (Collier et al 1992; McGill et al 1994; Bagg et al 2001; Aso et al 2002; Leurs et al 2002; Rigla et al 2006).
Positive_regulation (Increased) of Gene_expression (levels) of vWF associated with diabetes mellitus
1) Confidence 0.42 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 1.21 Pain Relevance 0.04
This was paralleled by elevated levels of vWF, immediately and 24 hours after ROSC, compared with normal values.
Positive_regulation (elevated) of Gene_expression (levels) of vWF
2) Confidence 0.41 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 0.08 Pain Relevance 0.04
In one study, circulating t-PA antigen correlated strongly with circulating levels of von Willebrand factor (vWF), another endothelial release product, as well as with risk markers associated with endothelial dysfunction.
Positive_regulation (circulating) of Gene_expression (levels) of vWF
3) Confidence 0.29 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 0.28 Pain Relevance 0.11
In one study, circulating t-PA antigen correlated strongly with circulating levels of von Willebrand factor (vWF), another endothelial release product, as well as with risk markers associated with endothelial dysfunction.
Positive_regulation (circulating) of Gene_expression (levels) of von Willebrand factor
4) Confidence 0.29 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 0.28 Pain Relevance 0.11
Increased levels of factor VIII and von Willebrand factor may play a pathogenetic role in the development of portal, splenic, and mesenteric thrombosis.
Positive_regulation (Increased) of Gene_expression (levels) of von Willebrand factor associated with thrombosis
5) Confidence 0.29 Published 2002 Journal Z Gastroenterol Section Abstract Doc Link 12055664 Disease Relevance 0.89 Pain Relevance 0.17
Furthermore, it has been recently demonstrated that monocytes can acquire endothelial markers in vitro by uptake of platelet microparticles, as a simple transfer of antigens CD31 and vWF [28].
Positive_regulation (transfer) of Gene_expression (transfer) of vWF in platelet
6) Confidence 0.29 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0.18 Pain Relevance 0.06
Resuscitated patients showed significant elevated plasma levels of vWF immediately (296.5 ± 73.4%; P < 0.05) and 24 hours after ROSC (304.4 ± 22.8%; P < 0.001), compared with normal values of our institutional laboratory (50 to 160%), indicating endothelial damage or dysfunction.
Positive_regulation (elevated) of Gene_expression (levels) of vWF in plasma
7) Confidence 0.28 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 0.14 Pain Relevance 0
A variety of markers indicate endothelial dysfunction including: poor EC-dependent vasodilation, increased blood levels of von Willebrand factor (vWF), thrombomodulin, selectin, PAI-1, type IV collagen and t-PA were demonstrated in this patients population (Yaqoob et al 1993; Dosquet et al 1994; Myrup et al 1994; Makimattila et al 1996; Huszka et al 1997; Cosentino and Luscher 1998; Elhadd et al 1998; Malamitsi et al 1998; Huvers et al 1999).
Positive_regulation (increased) of Gene_expression (levels) of vWF in blood associated with increased venous pressure under development
8) Confidence 0.23 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.61 Pain Relevance 0
Compared with controls, women with migraine had higher adjusted odds ratios for elevated von Willebrand factor activity of 6.51 (95% CI, 1.94 to 21.83) in those with MA and of 4.59 (95% CI, 1.37 to 15.38) in those with MO, elevated high-sensitivity C-reactive protein of 7.99 (95% CI, 2.32 to 27.61) in those with MA and of 2.63 (95% CI, 0.73 to 9.45) in those with MO, and for lower nitrate/nitrite levels of 6.60 (95% CI, 2.06 to 21.16) in those with MA and of 3.03 (95% CI, 0.90 to 10.15) in those with MO.
Positive_regulation (elevated) of Gene_expression (activity) of von Willebrand factor
9) Confidence 0.13 Published 2009 Journal Stroke Section Body Doc Link 19608996 Disease Relevance 0.07 Pain Relevance 0
Compared with controls, women with migraine had higher adjusted odds ratios for elevated von Willebrand factor activity of 6.51 (95% CI, 1.94 to 21.83) in those with MA and of 4.59 (95% CI, 1.37 to 15.38) in those with MO, elevated high-sensitivity C-reactive protein of 7.99 (95% CI, 2.32 to 27.61) in those with MA and of 2.63 (95% CI, 0.73 to 9.45) in those with MO, and for lower nitrate/nitrite levels of 6.60 (95% CI, 2.06 to 21.16) in those with MA and of 3.03 (95% CI, 0.90 to 10.15) in those with MO.
Positive_regulation (elevated) of Gene_expression (activity) of von Willebrand factor
10) Confidence 0.13 Published 2009 Journal Stroke Section Body Doc Link 19608996 Disease Relevance 0.07 Pain Relevance 0
In order to study the phenotype of CD31+ cells thus obtained, we confirmed the endothelial phenotype of our CD31+ twice-purified hESC-ECs by flow cytometry analysis for the expression of vWF, CD31, and VE-cadherin (BD Biosciences), DiI-ac-LDL uptake assay, and Matrigel tube formation assay as previously described [15].


Positive_regulation (purified) of Gene_expression (expression) of vWF in tube
11) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 0.08 Pain Relevance 0
Although prothrombin time and activated partial thromboplastin time were within normal limits, the increased levels of FDP-E, D-dimer, and von Willebrand factor activity were observed, which suggested the endothelial cell activation and the coagulation/fibrinolysis system activation.
Positive_regulation (increased) of Gene_expression (levels) of von Willebrand factor in endothelial cell
12) Confidence 0.07 Published 2000 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Abstract Doc Link 10863331 Disease Relevance 0.94 Pain Relevance 0.13
Von Willebrand factor, mainly synthesized by endothelial cells and involved in platelet adhesion, is increased, reflecting endothelial activation or damage [61].
Positive_regulation (increased) of Gene_expression (synthesized) of Von Willebrand factor in endothelial cells associated with adhesions
13) Confidence 0.07 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.34 Pain Relevance 0.10

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