INT88987

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2007
Negated 0
Speculated 2
Reported most in Abstract
Documents 8
Total Number 11
Disease Relevance 10.46
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (HMGA2) protein binding transcription factor activity (HMGA2) DNA binding (HMGA2)
mitosis (HMGA2) nucleus (HMGA2) nucleic acid binding transcription factor activity (HMGA2)
Anatomy Link Frequency
neck 1
pancreas 1
head 1
HMGA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 11 91.44 High High
pruritus 4 85.28 High High
Pain 20 78.40 Quite High
headache 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 96 99.76 Very High Very High Very High
Pancreatic Cancer 35 99.72 Very High Very High Very High
Skin Cancer 2 99.28 Very High Very High Very High
Carcinoma 21 99.20 Very High Very High Very High
Cancer 128 98.92 Very High Very High Very High
Malignant Neoplastic Disease 17 98.20 Very High Very High Very High
Adenocarcinoma 13 97.60 Very High Very High Very High
Adenoma 16 97.44 Very High Very High Very High
Immunization 36 95.08 Very High Very High Very High
Genetic Translocation 6 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Abe et al, Cancer Res., 59: 1169-1174, 1999), we demonstrated that the expression level of the HMGI(Y) gene/proteins was significantly increased in colorectal adenocarcinoma and colorectal adenoma with severe cellular atypia.
Gene_expression (expression) of HMGI associated with adenoma, adenocarcinoma and cancer
1) Confidence 0.77 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10866296 Disease Relevance 0.57 Pain Relevance 0.05
Thus, an increased expression level of the HMGI(Y) proteins was clearly associated with the malignant phenotype in pancreatic tissue.
Gene_expression (expression) of HMGI associated with malignant neoplastic disease
2) Confidence 0.77 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10866296 Disease Relevance 1.25 Pain Relevance 0.08
In the current study, we analyzed HMGI(Y) expression in several human pancreatic lesions to investigate (a) whether HMGI(Y) overexpression is also observed in pancreatic carcinoma, and (b) the role of HMGI(Y) in the diagnosis of pancreatic neoplasms.
Spec (whether) Gene_expression (overexpression) of HMGI associated with pancreatic cancer
3) Confidence 0.77 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10866296 Disease Relevance 0.93 Pain Relevance 0.07
To this end, HMGI(Y) expression was determined at the protein level by immunohistochemistry using a HMGI(Y)-specific antibody in 6 surgically resected specimens of nonneoplastic tissue (4 specimens of normal pancreatic tissue and 2 specimens of chronic pancreatitis tissue), 8 pancreatic cystic neoplasms (5 intraductal papillary mucinous adenomas, 1 serous cystadenoma, and 2 solid pseudopapillary tumors), and 15 duct cell carcinomas of the pancreas.
Gene_expression (expression) of HMGI in pancreas associated with adenoma, serous cystadenoma, cancer, carcinoma and chronic pancreatitis
4) Confidence 0.77 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10866296 Disease Relevance 1.11 Pain Relevance 0.09
There was a strong correlation between HMGI(Y) protein overexpression and a diagnosis of carcinoma (P = 0.000018).
Gene_expression (overexpression) of HMGI associated with carcinoma
5) Confidence 0.77 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10866296 Disease Relevance 1.28 Pain Relevance 0.08
Hebert et al. reported that Hmga2 expression in head and neck squamous cell carcinoma cells was regulated in part by miR-98.
Gene_expression (expression) of Hmga2 in head associated with skin cancer
6) Confidence 0.72 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.09 Pain Relevance 0
In the current study, we analyzed HMGI(Y) expression in several human pancreatic lesions to investigate (a) whether HMGI(Y) overexpression is also observed in pancreatic carcinoma, and (b) the role of HMGI(Y) in the diagnosis of pancreatic neoplasms.
Gene_expression (role) of HMGI associated with pancreatic cancer
7) Confidence 0.67 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10866296 Disease Relevance 1.01 Pain Relevance 0.08
In the current study, we analyzed HMGI(Y) expression in several human pancreatic lesions to investigate (a) whether HMGI(Y) overexpression is also observed in pancreatic carcinoma, and (b) the role of HMGI(Y) in the diagnosis of pancreatic neoplasms.
Spec (analyzed) Gene_expression (expression) of HMGI associated with pancreatic cancer
8) Confidence 0.60 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10866296 Disease Relevance 0.89 Pain Relevance 0.06
Hebert et al. reported that Hmga2 expression in head and neck squamous cell carcinoma cells was regulated in part by miR-98.
Gene_expression (expression) of Hmga2 in neck associated with skin cancer
9) Confidence 0.25 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.09 Pain Relevance 0
As in previous clinical trials evaluating HIV lipopeptides [29], our LIPO-4 vaccine was well tolerated.
Gene_expression (vaccine) of LIPO-4 associated with acquired immune deficiency syndrome or hiv infection
10) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1942115 Disease Relevance 0.60 Pain Relevance 0.12
All the HIV-1 epitopes contained in LIPO-4 were tested independently of the volunteer's HLA haplotype.
Gene_expression (contained) of LIPO-4 associated with acquired immune deficiency syndrome or hiv infection
11) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1942115 Disease Relevance 0.64 Pain Relevance 0

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