INT88988

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2000
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 4.05
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (HMGA2) protein binding transcription factor activity (HMGA2) DNA binding (HMGA2)
mitosis (HMGA2) nucleus (HMGA2) nucleic acid binding transcription factor activity (HMGA2)
HMGA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 83.88 Quite High
Disease Link Frequency Relevance Heat
Adenocarcinoma 4 99.40 Very High Very High Very High
Carcinoma 12 99.20 Very High Very High Very High
Pancreatic Cancer 12 99.16 Very High Very High Very High
Cancer 16 98.92 Very High Very High Very High
Adenoma 8 98.20 Very High Very High Very High
Malignant Neoplastic Disease 4 98.20 Very High Very High Very High
Serous Cystadenoma 4 88.04 High High
Pancreatitis 4 83.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the current study, we analyzed HMGI(Y) expression in several human pancreatic lesions to investigate (a) whether HMGI(Y) overexpression is also observed in pancreatic carcinoma, and (b) the role of HMGI(Y) in the diagnosis of pancreatic neoplasms.
Spec (whether) Positive_regulation (overexpression) of Spec (whether) Gene_expression (overexpression) of HMGI associated with pancreatic cancer
1) Confidence 0.69 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10866296 Disease Relevance 0.93 Pain Relevance 0.07
Thus, an increased expression level of the HMGI(Y) proteins was clearly associated with the malignant phenotype in pancreatic tissue.
Positive_regulation (increased) of Gene_expression (expression) of HMGI associated with malignant neoplastic disease
2) Confidence 0.69 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10866296 Disease Relevance 1.26 Pain Relevance 0.08
Abe et al, Cancer Res., 59: 1169-1174, 1999), we demonstrated that the expression level of the HMGI(Y) gene/proteins was significantly increased in colorectal adenocarcinoma and colorectal adenoma with severe cellular atypia.
Positive_regulation (increased) of Gene_expression (expression) of HMGI associated with adenoma, adenocarcinoma and cancer
3) Confidence 0.69 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10866296 Disease Relevance 0.58 Pain Relevance 0.05
There was a strong correlation between HMGI(Y) protein overexpression and a diagnosis of carcinoma (P = 0.000018).
Positive_regulation (overexpression) of Gene_expression (overexpression) of HMGI associated with carcinoma
4) Confidence 0.46 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10866296 Disease Relevance 1.28 Pain Relevance 0.08

General Comments

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