INT88995

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 3.05
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTA2) small molecule metabolic process (GSTA2) cytoplasm (GSTA2)
Anatomy Link Frequency
liver 2
upper 2
hepatocyte 1
GSTA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 6 99.92 Very High Very High Very High
ischemia 12 99.46 Very High Very High Very High
lidocaine 4 88.60 High High
peptic ulcer disease 2 85.80 High High
Paracetamol 2 68.20 Quite High
Ultiva 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 12 99.46 Very High Very High Very High
Infection 8 99.40 Very High Very High Very High
Hepatic Encephalopathy 2 93.24 High High
Enteropathy 2 92.00 High High
Disease 4 88.04 High High
Ulcers 6 85.48 High High
Hepatotoxicity 6 85.36 High High
Reperfusion Injury 2 75.00 Quite High
Poisoning 2 68.60 Quite High
Injury 4 67.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that H. pylori infection and/or eradication treatment increased the releasing of alpha-glutathione S-transferase (alpha-GST).
Positive_regulation (increased) of alpha-glutathione S-transferase associated with infection
1) Confidence 0.49 Published 2007 Journal Current drug safety Section Abstract Doc Link 18690949 Disease Relevance 0.88 Pain Relevance 0.09
We hypothesized that H. pylori infection and/or eradication treatment increased the releasing of alpha-glutathione S-transferase (alpha-GST).
Positive_regulation (increased) of alpha-GST associated with infection
2) Confidence 0.43 Published 2007 Journal Current drug safety Section Abstract Doc Link 18690949 Disease Relevance 0.88 Pain Relevance 0.09
In contrast, patients receiving desflurane showed a transient slight, but significant, increase of alpha-GST to above the normal upper limit after anaesthesia, although this was without further clinical relevance.


Positive_regulation (increase) of alpha-GST in upper
3) Confidence 0.32 Published 2005 Journal Eur J Anaesthesiol Section Body Doc Link 15852994 Disease Relevance 0 Pain Relevance 0
RESULTS: alpha-GST increased significantly in the desflurane group from TO (3.0 +/- 2.2 microg L(-1)) to T1 and T2 (5.5 +/- 4.3 and 5.6 +/- 3.7 microg L(-1), respectively), whereas no changes were seen in the TIVA group. alpha-GST values above the normal upper limit (> 7.5 microg L(-1)) were seen in 24% of the patients receiving desflurane.
Positive_regulation (increased) of alpha-GST in upper
4) Confidence 0.30 Published 2005 Journal Eur J Anaesthesiol Section Body Doc Link 15852994 Disease Relevance 0 Pain Relevance 0
Increased serum levels of alpha GST and changes of gastric tonometry-derived variables imply a reduction in splanchnic perfusion, leading to a temporary impairment of hepatocyte oxygenation.
Positive_regulation (Increased) of alpha GST in hepatocyte
5) Confidence 0.25 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 10866914 Disease Relevance 0 Pain Relevance 0.31
Liver function was well preserved, whereas increased alpha glutathione S-transferase levels and changes in tonometry-derived variables indicated a reduction in splanchnic blood flow and a temporary impairment of hepatocyte oxygenation for both anesthetics.
Positive_regulation (increased) of alpha glutathione S-transferase in Liver
6) Confidence 0.25 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 10866914 Disease Relevance 0 Pain Relevance 0.24
In addition, only levels of alpha-GST significantly correlated with the Pringle duration. (3) The ischemia/reperfusion-induced early rise in alpha-GST was completely prevented by ischemic preconditioning.
Positive_regulation (rise) of alpha-GST associated with ischemia
7) Confidence 0.07 Published 2005 Journal World J Surg Section Abstract Doc Link 15776301 Disease Relevance 0.59 Pain Relevance 0.25
The major findings are as follows: (1) ALT, AST, and alpha-GST increased upon liver manipulation as early as prior to resection, with a rapid return of alpha-GST values to preoperative levels, whereas ALT and AST further increased on the first postoperative day. (2) In the PR group, alpha-GST, but not ALT and AST, was significantly elevated compared with that in the NPR group at 15 and 30 minutes and 2 hours after resection/reperfusion.
Positive_regulation (elevated) of alpha-GST in liver
8) Confidence 0.07 Published 2005 Journal World J Surg Section Abstract Doc Link 15776301 Disease Relevance 0.70 Pain Relevance 0.28

General Comments

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