INT89

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Context Info
Confidence 0.70
First Reported 1976
Last Reported 2010
Negated 12
Speculated 2
Reported most in Abstract
Documents 187
Total Number 189
Disease Relevance 80.49
Pain Relevance 42.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gast) extracellular region (Gast)
Anatomy Link Frequency
plasma 27
neurons 4
parietal cell 4
blood 3
stomach 3
Gast (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 295 100.00 Very High Very High Very High
Cholecystokinin 148 100.00 Very High Very High Very High
Neuropeptide 22 100.00 Very High Very High Very High
vagus nerve 5 100.00 Very High Very High Very High
Serotonin 5 100.00 Very High Very High Very High
substance P 5 100.00 Very High Very High Very High
cytokine 8 99.96 Very High Very High Very High
Nicotine 138 99.84 Very High Very High Very High
qutenza 68 99.84 Very High Very High Very High
abdominal pain 27 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Skin Infection 112 100.00 Very High Very High Very High
Appetite Loss 3 99.96 Very High Very High Very High
Syndrome 72 99.88 Very High Very High Very High
Gastritis 45 99.88 Very High Very High Very High
Hypoglycemia 1 99.80 Very High Very High Very High
Abdominal Pain 27 99.78 Very High Very High Very High
Duodenal Ulcer 90 99.76 Very High Very High Very High
Achlorhydria 17 99.76 Very High Very High Very High
Disease 198 99.72 Very High Very High Very High
Cancer 52 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naloxone had no effect on the noncholinergic, nonadrenergic stimulation of gastrin levels.
Positive_regulation (stimulation) of gastrin associated with narcan
1) Confidence 0.70 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3614557 Disease Relevance 0 Pain Relevance 0.85
Sodium taurocholate and deoxycholate (> 2.5 mM) significantly increased the serum levels of gastrin.
Positive_regulation (increased) of gastrin
2) Confidence 0.70 Published 1995 Journal J. Gastroenterol. Section Abstract Doc Link 7719401 Disease Relevance 0 Pain Relevance 0.60
Stimulation of both cervical vagi (10V, 5Hz, 5ms) elicited an increase of arterial plasma gastrin levels at intragastric pH7 or pH2.
Positive_regulation (increase) of gastrin in plasma
3) Confidence 0.70 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3614557 Disease Relevance 0 Pain Relevance 0.39
In anesthetized rats graded gastric distention by 5, 10 and 15 ml saline for 20 min caused a significant volume-dependent increase of plasma gastrin levels by 12+/-6 pg/ml (5 ml saline, n = 8, P =0.05), 26+/-7 pg/ml (10 ml saline, n = 10, P < 0.05) and 37+/-7 pg/ml (15 ml saline, n = 8, P < 0.01 ), respectively.
Positive_regulation (increase) of gastrin in plasma
4) Confidence 0.70 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9163580 Disease Relevance 0 Pain Relevance 0.12
In man the increase of gastrin is less marked even after administration of omeprazole, the most potent inhibitor of acid secretion known.
Positive_regulation (increase) of gastrin
5) Confidence 0.70 Published 1985 Journal Schweiz Med Wochenschr Suppl Section Abstract Doc Link 2865808 Disease Relevance 0.66 Pain Relevance 0.08
"Soft" antiulcer drugs like prostaglandins do not increase gastrin levels.
Neg (not) Positive_regulation (increase) of gastrin
6) Confidence 0.70 Published 1986 Journal Klin. Wochenschr. Section Abstract Doc Link 3104657 Disease Relevance 0.76 Pain Relevance 0.26
The increase of serum gastrin levels by luminal alkalization was significantly inhibited (50%) after administration of 4% lidocaine.
Positive_regulation (increase) of gastrin associated with lidocaine
7) Confidence 0.69 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10877240 Disease Relevance 0 Pain Relevance 0.67
Scorpion toxin induced a significant increase in volume, acid output and pepsin output of gastric juice and gastrin serum levels 15-60 min after injection.
Positive_regulation (increase) of gastrin in gastric juice
8) Confidence 0.69 Published 1998 Journal Toxicon Section Abstract Doc Link 9839667 Disease Relevance 0 Pain Relevance 0
Scorpion toxin significantly increased serum gastrin; levels in rats.
Positive_regulation (increased) of gastrin
9) Confidence 0.69 Published 1998 Journal Toxicon Section Abstract Doc Link 9839667 Disease Relevance 0 Pain Relevance 0
The results obtained after repeated oral administration for 15 days of ebrotidine and ranitidine at the doses of 15 and 50 mg/kg demonstrated that ebrotidine did not increase significantly serum gastrin levels with respect to control 2 h after administration, and no dose-related effect was observed.
Neg (not) Positive_regulation (increase) of gastrin
10) Confidence 0.69 Published 1997 Journal Arzneimittelforschung Section Abstract Doc Link 9205740 Disease Relevance 0 Pain Relevance 0.22
In contrast, ranitidine increased serum gastrin levels significantly and in a dose-dependent manner with respect to control group.
Positive_regulation (increased) of gastrin
11) Confidence 0.69 Published 1997 Journal Arzneimittelforschung Section Abstract Doc Link 9205740 Disease Relevance 0 Pain Relevance 0.24
In contrast, ranitidine at a single oral dose of 100 mg/kg increased serum gastrin levels more markedly within 2 and 5 h after administration, while after 8 h, this increase still persisted although without significant differences with respect to control, and after 24 h levels returned to normal values.
Positive_regulation (increased) of gastrin
12) Confidence 0.69 Published 1997 Journal Arzneimittelforschung Section Abstract Doc Link 9205740 Disease Relevance 0 Pain Relevance 0.15
It was noted that ulcer occurrence was preceded by the increased serum gastrin level.
Positive_regulation (increased) of gastrin associated with ulcers
13) Confidence 0.69 Published 1982 Journal Biull Eksp Biol Med Section Abstract Doc Link 7115528 Disease Relevance 0.46 Pain Relevance 0.35
Following removal of burimamide, 3 X 10(-6) M tetrodotoxin did not block gastrin stimulation of H+ secretion indicating that neural mechanisms are not required.
Positive_regulation (stimulation) of gastrin in neural associated with tetrodotoxin
14) Confidence 0.69 Published 1978 Journal Experientia Section Abstract Doc Link 658248 Disease Relevance 0 Pain Relevance 0.17
Circumstantial evidence suggests that the abnormal gastrin release could also explain the upregulation of the parietal cell to the acid stimulatory effect and the consequent increase in gastrin sensitivity in patients suffering from duodenal ulcer disease.
Positive_regulation (increase) of gastrin in parietal cell associated with duodenal ulcer
15) Confidence 0.69 Published 1991 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 1940201 Disease Relevance 0.90 Pain Relevance 0.12
DMPP caused lesser, though significant, increases in gastrin (166%) and somatostatin (83%) secretion that were nearly abolished by hexamethonium (84-91%) but were not significantly affected by atropine.
Positive_regulation (increases) of gastrin associated with somatostatin
16) Confidence 0.69 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2892415 Disease Relevance 0 Pain Relevance 0.47
Field stimulation caused an increase in gastrin and somatostatin secretion that was dependent on the strength of the stimulus (10-30 V).
Positive_regulation (increase) of gastrin associated with somatostatin
17) Confidence 0.69 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2892415 Disease Relevance 0 Pain Relevance 0.35
Field stimulation at 30 V, 10 Hz, 4 ms caused a sixfold increase in gastrin and a twofold increase in somatostatin secretion that were nearly abolished by tetrodotoxin (85-89% inhibition).
Positive_regulation (increase) of gastrin associated with tetrodotoxin and somatostatin
18) Confidence 0.69 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2892415 Disease Relevance 0 Pain Relevance 0.41
The slight increase in plasma gastrin concentration following proximal gastric vagotomy despite a lesser reduction in intragastric acidity may be the result of additional effects on gastrin release by the vagotomy.
Positive_regulation (increase) of gastrin in plasma
19) Confidence 0.68 Published 1990 Journal Gastroenterology Section Abstract Doc Link 2227275 Disease Relevance 0.26 Pain Relevance 0.06
Serum gastrin levels significantly increased during treatment but returned to normal levels after the treatment was discontinued.
Positive_regulation (increased) of gastrin
20) Confidence 0.68 Published 1986 Journal Drugs Exp Clin Res Section Abstract Doc Link 3530677 Disease Relevance 0.25 Pain Relevance 0.09

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