INT89011

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Context Info
Confidence 0.19
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 6
Disease Relevance 2.41
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Insr) intracellular (Lep) lipid metabolic process (Lep)
cytosol (Insr) extracellular space (Lep) extracellular region (Lep)
Anatomy Link Frequency
Arc 2
DMH 2
brainstem 2
Lep (Rattus norvegicus)
Insr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 18 98.56 Very High Very High Very High
Dynorphin 6 95.36 Very High Very High Very High
parabrachial 6 95.24 Very High Very High Very High
cocaine 6 94.64 High High
Cholecystokinin 6 87.44 High High
Central nervous system 6 70.56 Quite High
Neuropeptide 6 47.76 Quite Low
Enkephalin 6 25.00 Low Low
Disease Link Frequency Relevance Heat
Aids-related Complex 30 99.80 Very High Very High Very High
Body Weight 12 66.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the Arc and DMH, leptin-induced Fos-IR was observed in neurons that expressed neurotensin mRNA.
leptin Positive_regulation (induced) of Fos-IR in Arc associated with aids-related complex
1) Confidence 0.19 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10867658 Disease Relevance 0.43 Pain Relevance 0.30
In addition, leptin-induced Fos-IR was found in several nuclei of the brainstem, including the superior lateral and external lateral subdivisions of the parabrachial nucleus (slPB and elPB, respectively), the supragenual nucleus, and the nucleus of the solitary tract (NTS).
leptin Positive_regulation (induced) of Fos-IR in brainstem associated with medulla and parabrachial
2) Confidence 0.19 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10867658 Disease Relevance 0.34 Pain Relevance 0.19
In the Arc and DMH, leptin-induced Fos-IR was observed in neurons that expressed neurotensin mRNA.
leptin Positive_regulation (induced) of Fos-IR in Arc associated with aids-related complex
3) Confidence 0.13 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10867658 Disease Relevance 0.43 Pain Relevance 0.30
In addition, leptin-induced Fos-IR was found in several nuclei of the brainstem, including the superior lateral and external lateral subdivisions of the parabrachial nucleus (slPB and elPB, respectively), the supragenual nucleus, and the nucleus of the solitary tract (NTS).
leptin Positive_regulation (induced) of Fos-IR in brainstem associated with medulla and parabrachial
4) Confidence 0.13 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10867658 Disease Relevance 0.34 Pain Relevance 0.19
In the Arc and DMH, leptin-induced Fos-IR was observed in neurons that expressed neurotensin mRNA.
leptin Positive_regulation (induced) of Fos-IR in DMH associated with aids-related complex
5) Confidence 0.06 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10867658 Disease Relevance 0.43 Pain Relevance 0.30
In the Arc and DMH, leptin-induced Fos-IR was observed in neurons that expressed neurotensin mRNA.
leptin Positive_regulation (induced) of Fos-IR in DMH associated with aids-related complex
6) Confidence 0.05 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10867658 Disease Relevance 0.43 Pain Relevance 0.30

General Comments

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