INT89016

Context Info Confidence 0.06 First Reported 2000 Last Reported 2000 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

plasma membrane (Oprd1, Drd1a) signal transducer activity (Oprd1, Drd1a) endoplasmic reticulum (Drd1a) nucleus (Drd1a) intracellular (Drd1a) cytoplasm (Oprd1)

Oprd1 (Rattus norvegicus) Drd1a (Rattus norvegicus)

Pain Link Frequency Relevance Heat agonist 1 50.00 cocaine 1 50.00 Eae 1 50.00 Kappa opioid receptor 1 50.00 Analgesic 1 10.00 Opioid 1 5.00

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Unlike U69593 and U50488H, bremazocine is also an antagonist at mu- and delta-opioid receptors, as well as an agonist at a subtype of delta-opioid receptors inhibiting dopamine D1 receptor-stimulated adenylate cyclase.

delta-opioid Negative_regulation (inhibiting) of dopamine D1 receptor

1) Confidence 0.06 Published 2000 Journal Psychopharmacology (Berl.) Section Body Doc Link 10867974 Disease Relevance 0 Pain Relevance 0

General Comments

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