INT89026

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 7.25
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nt5e) cytoplasm (Nt5e)
Anatomy Link Frequency
lung 2
lower respiratory tract 1
fibroblast 1
epithelium 1
endothelium 1
Nt5e (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 292 100.00 Very High Very High Very High
Inflammatory stimuli 4 99.54 Very High Very High Very High
Inflammation 208 97.60 Very High Very High Very High
antagonist 60 96.88 Very High Very High Very High
Inflammatory response 40 93.04 High High
gABA 12 87.16 High High
chemokine 36 82.00 Quite High
anesthesia 10 75.00 Quite High
Potency 4 59.52 Quite High
agonist 52 54.32 Quite High
Disease Link Frequency Relevance Heat
Iron Overload 3 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 244 99.90 Very High Very High Very High
Respiratory Syncytial Virus 198 99.76 Very High Very High Very High
Infection 202 99.60 Very High Very High Very High
INFLAMMATION 178 99.36 Very High Very High Very High
Hypoxia 54 98.90 Very High Very High Very High
Sepsis 21 98.56 Very High Very High Very High
Pneumonia 121 94.88 High High
Sprains And Strains 48 93.92 High High
Osteoporosis 42 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results are compatible either with a structural model of the binding site that can accommodate 3alpha5alphaP, 3alpha5betaP, and ent-3alpha5betaP, but not ent-3alpha5alphaP, or with two different binding sites for steroid anesthetics.
Positive_regulation (accommodate) of ent
1) Confidence 0.49 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10869405 Disease Relevance 0 Pain Relevance 0.29
The results are compatible either with a structural model of the binding site that can accommodate 3alpha5alphaP, 3alpha5betaP, and ent-3alpha5betaP, but not ent-3alpha5alphaP, or with two different binding sites for steroid anesthetics.
Positive_regulation (accommodate) of ent
2) Confidence 0.49 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10869405 Disease Relevance 0 Pain Relevance 0.29
This increase is paralleled by induction of the rate-limiting enzymes for extracellular adenosine generation CD39 and CD73 on pulmonary endothelium and epithelium.
Positive_regulation (induction) of CD73 in epithelium associated with adenocard
3) Confidence 0.41 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.62 Pain Relevance 0.41
ALI was enhanced in CD39-/- and CD73-/- mice, as indicated by impaired oxygenation and increased protein content of the BAL fluid, increased PMN infiltration, and increased lung water content [35].
Positive_regulation (enhanced) of CD73 in lung associated with adult respiratory distress syndrome
4) Confidence 0.29 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.64 Pain Relevance 0.40
Interestingly, pulmonary PMN infiltration after hypoxia, a potent inflammatory stimulus in the lung, was also increased in CD39-/- and CD73-/- mice [36].
Positive_regulation (increased) of CD73 in lung associated with hypoxia and inflammatory stimuli
5) Confidence 0.29 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.65 Pain Relevance 0.46
This increase is paralleled by induction of the rate-limiting enzymes for extracellular adenosine generation CD39 and CD73 on pulmonary endothelium and epithelium.
Positive_regulation (induction) of CD73 in endothelium associated with adenocard
6) Confidence 0.14 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.62 Pain Relevance 0.41
-regulated genes (VEGF, CD73, FN-1, COX-2) were induced with RSV infection of wild-type cells.
Positive_regulation (induced) of CD73 associated with infection and respiratory syncytial virus
7) Confidence 0.12 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2556398 Disease Relevance 2.07 Pain Relevance 0.07
Alternatively, if K. pneumoniae reaches the lower respiratory tract where it can replicate to high numbers (>109 CFU/gm) [22], there may be a dramatic increase in Ent-Lcn2 formation with a more significant effect of Lcn2 on the immune response.
Positive_regulation (increase) of Ent in lower respiratory tract
8) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.57 Pain Relevance 0.10
When bacterial growth outpaces Fe availability, an increased proportion of Ent will be aferric.
Positive_regulation (increased) of Ent
9) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.23 Pain Relevance 0.21
Bacterial growth can be restored by the addition of excess iron [2] or Ent [3].
Positive_regulation (excess) of Ent associated with iron overload
10) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.52 Pain Relevance 0
These studies revealed significant induction of HIF-1-target genes (VEGF, CD73 or FN1) in control cells, while these responses were abolished in HIF-1?
Positive_regulation (induction) of CD73
11) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.06 Pain Relevance 0.03
The cell surfaces were positive for mesenchymal stem cell markers, CD105, CD90, and CD73, and negative for the marker of the hematopoietic origin, CD34 [Figure 1].
Positive_regulation (positive) of CD73 in stem cell
12) Confidence 0.03 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.09 Pain Relevance 0
Isolated PB-hMSCs showed fibroblast-like morphology and were positive for MSC surface molecules (CD90, CD105, CD73) and negative for markers of hematopoietic progenitors (CD34).
Positive_regulation (positive) of CD73 in fibroblast
13) Confidence 0.03 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.18 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox