INT8903

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Context Info
Confidence 0.71
First Reported 1983
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 58
Total Number 60
Disease Relevance 38.23
Pain Relevance 8.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNA2) extracellular region (IFNA2) cell-cell signaling (IFNA2)
Anatomy Link Frequency
blood 6
liver 2
lymphocyte 2
lymph nodes 1
ventricle 1
IFNA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 25 100.00 Very High Very High Very High
Opioid 10 100.00 Very High Very High Very High
palliative 4 100.00 Very High Very High Very High
Central nervous system 9 99.68 Very High Very High Very High
Arthritis 65 99.56 Very High Very High Very High
methotrexate 6 99.08 Very High Very High Very High
local anesthetic 2 98.92 Very High Very High Very High
vincristine 2 98.52 Very High Very High Very High
imagery 6 98.00 Very High Very High Very High
narcan 6 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Metastasis 56 100.00 Very High Very High Very High
Neuroendocrine Cancer 1 99.98 Very High Very High Very High
Recurrence 14 99.92 Very High Very High Very High
Lung Cancer 13 99.84 Very High Very High Very High
Pleural Effusion 6 99.84 Very High Very High Very High
Disease 151 99.80 Very High Very High Very High
Arthritis 66 99.56 Very High Very High Very High
Dengue 26 99.48 Very High Very High Very High
Hepatitis B Virus Infection 345 99.24 Very High Very High Very High
Systemic Lupus Erythematosus 19 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Psychosis results from in situ viral stimulation of aIFN production in the CNS of a vulnerable host having defective regulation of either sensitivity or production.
Gene_expression (production) of aIFN in CNS associated with psychosis and central nervous system
1) Confidence 0.71 Published 1990 Journal J. Nerv. Ment. Dis. Section Abstract Doc Link 2246646 Disease Relevance 0.81 Pain Relevance 0.28
Finally the production of interferon-alpha and of prostaglandin E2 induced by stimulation of the cells with endotoxin (LPS) was diminished.
Gene_expression (production) of interferon-alpha
2) Confidence 0.70 Published 1997 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 9278179 Disease Relevance 0.08 Pain Relevance 0.40
Positive interrelation has been found out between individual ME concentrations and lymphocyte abilities to a-IFN production with the coefficient of correlation equal to 0.69.
Gene_expression (production) of a-IFN in lymphocyte associated with enkephalin
3) Confidence 0.68 Published 1990 Journal Biull Eksp Biol Med Section Abstract Doc Link 2143090 Disease Relevance 0 Pain Relevance 0.61
The levels of met-enkephalin (ME), beta-endorphin (BE), and alpha-interferon (a-IFN) have been determined in the human blood 1 day after dipyridamole administration.
Spec (determined) Gene_expression (levels) of a-IFN in blood associated with enkephalin
4) Confidence 0.68 Published 1990 Journal Biull Eksp Biol Med Section Abstract Doc Link 2143090 Disease Relevance 0 Pain Relevance 0.47
Interferon-alpha was administered after nephrectomy and following palliative irradiation of the metastasis, but could not be continued because of allograft dysfunction.
Neg (not) Gene_expression (continued) of Interferon-alpha associated with metastasis and palliative
5) Confidence 0.68 Published 2009 Journal Int. J. Clin. Oncol. Section Abstract Doc Link 19856059 Disease Relevance 0.79 Pain Relevance 0.15
[Blood levels of opioid peptides and alpha interferon under the action of dipyridamole].
Gene_expression (levels) of alpha interferon in Blood associated with opioid
6) Confidence 0.67 Published 1990 Journal Biull Eksp Biol Med Section Title Doc Link 2143090 Disease Relevance 0 Pain Relevance 0.60
The objective of this study was to evaluate intralesional injections of interferon alpha 2B (IFN-alpha-2B) as an effective alternative to the surgical treatment of Peyronie's disease.
Gene_expression (injections) of IFN-alpha-2B associated with disease
7) Confidence 0.67 Published 1999 Journal J. Androl. Section Abstract Doc Link 10452584 Disease Relevance 0.36 Pain Relevance 0.03
The objective of this study was to evaluate intralesional injections of interferon alpha 2B (IFN-alpha-2B) as an effective alternative to the surgical treatment of Peyronie's disease.
Gene_expression (injections) of interferon alpha 2B associated with disease
8) Confidence 0.67 Published 1999 Journal J. Androl. Section Abstract Doc Link 10452584 Disease Relevance 0.36 Pain Relevance 0.03
Pharmacokinetic studies showed i.p. levels of rIFN-alpha 2 were 30-1000 times blood levels.
Gene_expression (levels) of rIFN-alpha 2 in blood
9) Confidence 0.66 Published 1985 Journal Cancer Treat. Rev. Section Abstract Doc Link 3833327 Disease Relevance 0.73 Pain Relevance 0.08
Pharmacokinetic studies show that i.p. levels of rIFN-alpha 2 were 30-1000 times blood levels. rIFN-alpha 2 i.p. may act by increasing concentrations of drug and augmenting regional host cells in patients with minimal residual ovarian cancer.
Gene_expression (levels) of rIFN-alpha 2 in blood associated with ovarian cancer
10) Confidence 0.66 Published 1985 Journal Cancer Res. Section Abstract Doc Link 4028027 Disease Relevance 0.89 Pain Relevance 0.07
[A case of renal cell carcinoma complicated with interstitial pneumonitis, complete A-V block and pleural effusion during interferon-alpha therapy].
Gene_expression (therapy) of interferon-alpha associated with pleural effusion, interstitial lung diseases and renal cancer
11) Confidence 0.65 Published 2001 Journal Nihon Kokyuki Gakkai Zasshi Section Title Doc Link 11855092 Disease Relevance 1.19 Pain Relevance 0.09
Recombinant human alpha-interferon infused intravenously into rats at doses of 10(6) (1st infusion) and 10(5) IU (2nd and 3rd infusion) produced marginal evidence of liver damage but no serious toxicity.
Gene_expression (produced) of alpha-interferon in liver associated with toxicity and hepatotoxicity
12) Confidence 0.62 Published 1990 Journal Toxicol. Lett. Section Abstract Doc Link 2296775 Disease Relevance 0.36 Pain Relevance 0.11
The levels of met-enkephalin (ME), beta-endorphin (BE), and alpha-interferon (a-IFN) have been determined in the human blood 1 day after dipyridamole administration.
Spec (determined) Gene_expression (levels) of alpha-interferon in blood associated with enkephalin
13) Confidence 0.60 Published 1990 Journal Biull Eksp Biol Med Section Abstract Doc Link 2143090 Disease Relevance 0 Pain Relevance 0.47
The (mu) opiate receptor antagonist, naloxone, was found to decrease the amount of EEG synchronization and blocked the increases in synchronized sleep produced by 250 U alpha-IFN.
Gene_expression (produced) of alpha-IFN associated with antagonist, narcan and opiate
14) Confidence 0.56 Published 1990 Journal J. Neurol. Sci. Section Abstract Doc Link 1965206 Disease Relevance 0 Pain Relevance 0.50
The main purpose of this article is to discuss the advances in medical therapy for Peyronie's disease, in particular intralesional injection of interferon-alpha-2b (IFN-alpha-2b).
Gene_expression (injection) of IFN-alpha-2b associated with disease
15) Confidence 0.55 Published 2002 Journal Int. J. Impot. Res. Section Abstract Doc Link 12454683 Disease Relevance 0.91 Pain Relevance 0.20
Conventional interferon alpha
Gene_expression (Conventional) of interferon alpha
16) Confidence 0.55 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2426802 Disease Relevance 0.79 Pain Relevance 0.04
Interferon-alpha(IFN-alpha) is used clinically in the treatment of several pathologies such as hepatitis C and various cancers.
Gene_expression (used) of IFN-alpha associated with cancer and hepatitis
17) Confidence 0.54 Published 2002 Journal Physiol. Behav. Section Abstract Doc Link 12020742 Disease Relevance 0.38 Pain Relevance 0.11
Interferon-alpha(IFN-alpha) is used clinically in the treatment of several pathologies such as hepatitis C and various cancers.
Gene_expression (used) of Interferon-alpha associated with cancer and hepatitis
18) Confidence 0.54 Published 2002 Journal Physiol. Behav. Section Abstract Doc Link 12020742 Disease Relevance 0.38 Pain Relevance 0.11
Recombinant human alpha-interferon infused intravenously into rats at doses of 10(6) (1st infusion) and 10(5) IU (2nd and 3rd infusion) produced marginal evidence of liver damage but no serious toxicity.
Gene_expression (produced) of alpha-interferon in liver associated with toxicity and hepatotoxicity
19) Confidence 0.54 Published 1990 Journal Toxicol. Lett. Section Abstract Doc Link 2296775 Disease Relevance 0.36 Pain Relevance 0.11
Dipyridamole led to an increase in serum a-IFN concentration up to 3 times, and to simultaneous rise of the lymphocytes ability to produce a-IFN.
Gene_expression (produce) of a-IFN in lymphocytes
20) Confidence 0.52 Published 1990 Journal Biull Eksp Biol Med Section Abstract Doc Link 2143090 Disease Relevance 0 Pain Relevance 0.57

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