INT89033

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.60
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grpr) plasma membrane (Grpr) signal transducer activity (Grpr)
Grpr (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 99.80 Very High Very High Very High
Pain 6 96.40 Very High Very High Very High
Neuropathic pain 2 95.84 Very High Very High Very High
Inflammation 2 95.00 High High
Spinal cord 8 92.20 High High
Root ganglion neuron 2 88.48 High High
antagonist 2 86.32 High High
Central nervous system 2 76.40 Quite High
pruritus 3 75.00 Quite High
Eae 2 68.64 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 2 95.84 Very High Very High Very High
INFLAMMATION 2 95.00 High High
Ganglion Cysts 2 88.16 High High
Pruritus 19 81.88 Quite High
Eczema 2 73.44 Quite High
Skin Diseases 2 72.40 Quite High
Pain 2 71.92 Quite High
Liver Disease 2 70.72 Quite High
Renal Disease 2 69.96 Quite High
Anxiety Disorder 2 35.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Male mice lacking the gastrin-releasing peptide receptor (GRP-R) display elevated preference for conspecific odors and increased social investigatory behaviors.
Negative_regulation (lacking) of gastrin-releasing peptide receptor associated with anesthesia
1) Confidence 0.43 Published 2000 Journal Brain Res. Section Title Doc Link 10869497 Disease Relevance 0 Pain Relevance 0.13
Male mice lacking the gastrin-releasing peptide receptor (GRP-R) display elevated preference for conspecific odors and increased social investigatory behaviors.
Negative_regulation (lacking) of GRP-R associated with anesthesia
2) Confidence 0.42 Published 2000 Journal Brain Res. Section Title Doc Link 10869497 Disease Relevance 0 Pain Relevance 0.13
In contrast, induction of scratching behaviour was significantly reduced in GRPR mutant mice in response to pruritogenic stimuli, whereas normal responses were evoked by painful stimuli.
Negative_regulation (reduced) of GRPR associated with pain
3) Confidence 0.37 Published 2007 Journal Nature Section Abstract Doc Link 17653196 Disease Relevance 1.27 Pain Relevance 0.65
In contrast, induction of scratching behaviour was significantly reduced in GRPR mutant mice in response to pruritogenic stimuli, whereas normal responses were evoked by painful stimuli.
Negative_regulation (reduced) of GRPR associated with pain
4) Confidence 0.37 Published 2008 Journal J. Hepatol. Section Abstract Doc Link 18280606 Disease Relevance 1.33 Pain Relevance 0.68

General Comments

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