INT8904

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 66
Total Number 76
Disease Relevance 65.40
Pain Relevance 14.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EDN1) extracellular region (EDN1) cell-cell signaling (EDN1)
cytoplasm (EDN1)
Anatomy Link Frequency
forearm 20
plasma 13
smooth muscle cells 8
endothelial cells 8
platelet 4
EDN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 58 100.00 Very High Very High Very High
noradrenaline 2 100.00 Very High Very High Very High
cytokine 139 99.98 Very High Very High Very High
anesthesia 6 99.96 Very High Very High Very High
Inflammation 263 99.78 Very High Very High Very High
narcan 2 99.70 Very High Very High Very High
Bioavailability 28 99.58 Very High Very High Very High
Cancer pain 6 99.50 Very High Very High Very High
fibrosis 127 99.36 Very High Very High Very High
Osteoarthritis 151 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 1139 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 644 100.00 Very High Very High Very High
Cancer 503 100.00 Very High Very High Very High
Disease 459 100.00 Very High Very High Very High
Pressure And Volume Under Development 132 100.00 Very High Very High Very High
Coronary Artery Disease 94 100.00 Very High Very High Very High
Depression 58 100.00 Very High Very High Very High
Atherosclerosis 22 100.00 Very High Very High Very High
Sprains And Strains 38 99.98 Very High Very High Very High
Breast Cancer 48 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indomethacin treatment produced a small increase in weight (1.4 +/- 0.4 kg; 0.6 to 2.2 kg), a small reduction in renal function (creatinine clearance: 6.8 +/- 1.8 mis/min; 3.3 to 10.3 mis/min) but a significant (83%) increase in daily urinary endothelin-1 production (13.1 +/- 3.4 ng/ml; 6.4 to 19.8 ng/ml) without altering plasma ET-1 concentration, suggesting increased renal synthesis.
Positive_regulation (increase) of Gene_expression (production) of endothelin-1 in plasma associated with disorders of creatine metabolism
1) Confidence 0.70 Published 1996 Journal J Hum Hypertens Section Abstract Doc Link 8736458 Disease Relevance 0.41 Pain Relevance 0.24
Effects of propofol on cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells.
Positive_regulation (induced) of Gene_expression (expression) of endothelin-1 in umbilical vein associated with sprains and strains
2) Confidence 0.67 Published 2009 Journal Anesthesiology Section Title Doc Link 19104173 Disease Relevance 0.28 Pain Relevance 0.10
RESULTS: The authors show that propofol inhibits strain-induced ET-1 expression, strain-increased reactive oxygen species formation, and extracellular signal-regulated protein kinase phosphorylation.
Positive_regulation (induced) of Gene_expression (expression) of ET-1
3) Confidence 0.67 Published 2009 Journal Anesthesiology Section Body Doc Link 19104173 Disease Relevance 0 Pain Relevance 0
A locally increased endothelin production in coronary artery disease or other atherosclerotic diseases may increase circulating endothelin plasma concentrations before symptoms of disease are manifest.
Positive_regulation (increased) of Gene_expression (production) of endothelin in plasma associated with coronary artery disease, atherosclerosis and disease
4) Confidence 0.67 Published 1993 Journal Res Exp Med (Berl) Section Abstract Doc Link 8235075 Disease Relevance 0.98 Pain Relevance 0
Here we show that in a murine osteolytic 2472 sarcoma model of bone cancer pain, the 2472 sarcoma cells express high levels of ET-1, but express low or undetectable levels of endothelin A (ETAR) or B (ETBR) receptors whereas a subpopulation of sensory neurons express the ETAR and non-myelinating Schwann cells express the ETBR.
Positive_regulation (levels) of Gene_expression (express) of ET-1 in sensory neurons associated with sarcoma and cancer pain
5) Confidence 0.66 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207337 Disease Relevance 1.17 Pain Relevance 0.60
In pathological situations circulating pro-inflammatory cytokines induce the expression of iNOS and ET-1 in smooth muscle cells, also downregulating endothelial eNOS expression, resulting in an elevated ET-1 production and a decrease of NO [18,39].
Positive_regulation (elevated) of Gene_expression (production) of ET-1 in smooth muscle cells associated with inflammation and cytokine
6) Confidence 0.60 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693561 Disease Relevance 0.89 Pain Relevance 0.38
Several studies have demonstrated increased plasma ET-1 levels in NTG patients (Sugiyama et al 1995; Kaiser et al 1995), but these results have not been reproduced in patients with high tension glaucoma (HTG) (Tezel et al 1997).
Positive_regulation (increased) of Gene_expression (levels) of ET-1 in plasma associated with low tension glaucoma and glaucoma
7) Confidence 0.58 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 1.19 Pain Relevance 0
As expected, elevated ET-1 levels were observed in patients with IPF and scleroderma but not in those with chronic obstructive pulmonary disease or healthy control individuals (Figure 2).
Positive_regulation (elevated) of Gene_expression (levels) of ET-1 associated with fibrosis, pulmonary disease and systemic sclerosis
8) Confidence 0.54 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2072890 Disease Relevance 1.60 Pain Relevance 0.25
Although the study did not document clinical outcome in these patients, elevated ET-1 levels were observed in approximately 25% (Figure 3).
Positive_regulation (elevated) of Gene_expression (levels) of ET-1
9) Confidence 0.54 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2072890 Disease Relevance 1.44 Pain Relevance 0.22
Pretreatment of subjects with the selective histamine H1-receptor antagonist cetirizine, 10 mg orally 4 h before intradermal injections, inhibited vasodilatation caused by the intradermal injection of histamine (750 pmol), endothelin-1 (63 pmol), and carbachol (750 pmol).
Positive_regulation (caused) of Gene_expression (injection) of endothelin-1 associated with antagonist and increased venous pressure under development
10) Confidence 0.50 Published 1992 Journal Br. J. Dermatol. Section Abstract Doc Link 1382539 Disease Relevance 0.52 Pain Relevance 0.18
Thus, ET-1 generation from exogenously applied big ET-1 reflects the functional phosphoramidon-sensitive ECE activities in human aortic endothelial cells.
Positive_regulation (generation) of Gene_expression (generation) of ET-1 in endothelial cells
11) Confidence 0.50 Published 1995 Journal Biol. Pharm. Bull. Section Abstract Doc Link 7550091 Disease Relevance 0 Pain Relevance 0
This increase in big ET-1 release appeared to be partly due to a transient stimulation of the expression of prepro ET-1 mRNA.
Positive_regulation (stimulation) of Gene_expression (expression) of ET-1
12) Confidence 0.50 Published 1995 Journal Biol. Pharm. Bull. Section Abstract Doc Link 7550091 Disease Relevance 0 Pain Relevance 0
Thus, ET-1 generation from exogenously applied big ET-1 reflects the functional phosphoramidon-sensitive ECE activities in human aortic endothelial cells.
Positive_regulation (generation) of Gene_expression (generation) of ET-1 in endothelial cells
13) Confidence 0.50 Published 1995 Journal Biol. Pharm. Bull. Section Abstract Doc Link 7550091 Disease Relevance 0 Pain Relevance 0
A locally increased endothelin production in coronary artery disease or other atherosclerotic diseases may increase circulating endothelin plasma concentrations before symptoms of disease are manifest.
Spec (may) Positive_regulation (increase) of Gene_expression (production) of endothelin in plasma associated with coronary artery disease, atherosclerosis and disease
14) Confidence 0.49 Published 1993 Journal Res Exp Med (Berl) Section Abstract Doc Link 8235075 Disease Relevance 1.02 Pain Relevance 0
This suggests a hyperactive production and/or release of ET-1 in response to vasospastic stimuli in predisposed patients (Nicolela et al 2003).
Positive_regulation (response) of Gene_expression (production) of ET-1
15) Confidence 0.48 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 0.77 Pain Relevance 0
Ocular tissues, eg, vascular and extravascular sites in the retina are a rich source of ET-1 expression, and ET-1 contributes to abnormal retinal hemodynamics in diabetic retinopathy (Kohner et al 1995; Pang et al 1997).
Positive_regulation (source) of Gene_expression (expression) of ET-1 in retina associated with diabetic retinopathy
16) Confidence 0.48 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605330 Disease Relevance 1.64 Pain Relevance 0.20
The aims of this study were to test the hypothesis that propofol may alter strain-induced endothelin-1 (ET-1) secretion and nitric oxide production, and to identify the putative underlying signaling pathways in human umbilical vein endothelial cells.
Positive_regulation (induced) of Gene_expression (production) of endothelin-1 in endothelial cells associated with sprains and strains
17) Confidence 0.45 Published 2009 Journal Anesthesiology Section Abstract Doc Link 19104173 Disease Relevance 0.27 Pain Relevance 0.09
A feature of endothelial dysfunction is an increased expression of arterial vasoconstrictor endothelin (ET) and angiotensin (AT) receptors.
Positive_regulation (increased) of Gene_expression (expression) of endothelin
18) Confidence 0.45 Published 2009 Journal Heart Vessels Section Abstract Doc Link 20108069 Disease Relevance 0.74 Pain Relevance 0.16
MMP-1 production, MMP-13 production and NO production were studied in the absence of and in the presence of ET-1, using various inhibitors: 1 ?
Positive_regulation (studied) of Gene_expression (presence) of ET-1
19) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0 Pain Relevance 0.04
upregulates the synthesis of ET-1 [3], which in turn can induce IL-1?
Positive_regulation (upregulates) of Gene_expression (synthesis) of ET-1
20) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.46 Pain Relevance 0.23

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