INT89045

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Context Info
Confidence 0.41
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.75
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sensory neurons 2
P2RX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 40 99.82 Very High Very High Very High
Cancer pain 10 98.84 Very High Very High Very High
Analgesic 4 96.44 Very High Very High Very High
Spinal cord 18 95.12 Very High Very High Very High
Root ganglion neuron 2 94.96 High High
Acute pain 2 94.56 High High
painful pain 2 93.72 High High
adenocard 4 88.68 High High
antagonist 6 85.60 High High
Central nervous system 2 84.24 Quite High
Disease Link Frequency Relevance Heat
Bone Cancer 12 99.04 Very High Very High Very High
Pain 35 97.60 Very High Very High Very High
Carcinoma 6 96.60 Very High Very High Very High
Ganglion Cysts 2 94.64 High High
Nociception 3 93.12 High High
Metastasis 2 92.92 High High
Neuropathic Pain 46 73.28 Quite High
Disease 2 69.00 Quite High
Nervous System Injury 20 68.40 Quite High
Diabetes Mellitus 2 64.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats.
Negative_regulation (blockade) of P2X2 associated with pain, cancer pain and bone cancer
1) Confidence 0.41 Published 2010 Journal Brain Section Title Doc Link 20802203 Disease Relevance 0.71 Pain Relevance 1.07
These data suggest that blockade of P2X3 and P2X2/3 receptors on both the peripheral and central terminals of nocioceptors contributes to analgesic efficacy in a model of bone cancer pain.
Negative_regulation (blockade) of P2X2 associated with cancer pain, analgesic and bone cancer
2) Confidence 0.41 Published 2010 Journal Brain Section Abstract Doc Link 20802203 Disease Relevance 0.80 Pain Relevance 0.80
Following the pharmacological definition of distinct P2X and P2Y purinergic receptor subtypes by Burnstock and his collaborators, molecular cloning studies have identified the gene products that underlie the effects of ATP on peripheral sensory neurons.
Negative_regulation (definition) of P2X in sensory neurons
3) Confidence 0.37 Published 2000 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 10869734 Disease Relevance 0.41 Pain Relevance 0.27
However, neither blocking P2X/Y receptors pharmacologically nor suppressing the expression of P2X/Y receptors molecularly in sensory neurons or in the spinal cord had an effect on acute physiological pain.
Negative_regulation (blocking) of P2X in sensory neurons associated with pain, painful pain and spinal cord
4) Confidence 0.03 Published 2005 Journal Purinergic Signal Section Abstract Doc Link PMC2096535 Disease Relevance 0.83 Pain Relevance 0.74

General Comments

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