INT89045

Context Info Confidence 0.41 First Reported 2000 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 2.75 Pain Relevance 2.88

Anatomy Link Frequency sensory neurons 2 P2RX2 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 40 99.82 Cancer pain 10 98.84 Analgesic 4 96.44 Spinal cord 18 95.12 Root ganglion neuron 2 94.96 Acute pain 2 94.56 painful pain 2 93.72 adenocard 4 88.68 antagonist 6 85.60 Central nervous system 2 84.24

Disease Link Frequency Relevance Heat Bone Cancer 12 99.04 Pain 35 97.60 Carcinoma 6 96.60 Ganglion Cysts 2 94.64 Nociception 3 93.12 Metastasis 2 92.92 Neuropathic Pain 46 73.28 Disease 2 69.00 Nervous System Injury 20 68.40 Diabetes Mellitus 2 64.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats.

Negative_regulation (blockade) of P2X2 associated with pain, cancer pain and bone cancer

1) Confidence 0.41 Published 2010 Journal Brain Section Title Doc Link 20802203 Disease Relevance 0.71 Pain Relevance 1.07

These data suggest that blockade of P2X3 and P2X2/3 receptors on both the peripheral and central terminals of nocioceptors contributes to analgesic efficacy in a model of bone cancer pain.

Negative_regulation (blockade) of P2X2 associated with cancer pain, analgesic and bone cancer

2) Confidence 0.41 Published 2010 Journal Brain Section Abstract Doc Link 20802203 Disease Relevance 0.80 Pain Relevance 0.80

Following the pharmacological definition of distinct P2X and P2Y purinergic receptor subtypes by Burnstock and his collaborators, molecular cloning studies have identified the gene products that underlie the effects of ATP on peripheral sensory neurons.

Negative_regulation (definition) of P2X in sensory neurons

3) Confidence 0.37 Published 2000 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 10869734 Disease Relevance 0.41 Pain Relevance 0.27

However, neither blocking P2X/Y receptors pharmacologically nor suppressing the expression of P2X/Y receptors molecularly in sensory neurons or in the spinal cord had an effect on acute physiological pain.

Negative_regulation (blocking) of P2X in sensory neurons associated with pain, painful pain and spinal cord

4) Confidence 0.03 Published 2005 Journal Purinergic Signal Section Abstract Doc Link PMC2096535 Disease Relevance 0.83 Pain Relevance 0.74

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