INT89048

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 28
Total Number 28
Disease Relevance 8.75
Pain Relevance 7.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
bladder 8
sensory neurons 3
neurons 2
Neuronal 1
nerve 1
P2RX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 114 100.00 Very High Very High Very High
agonist 56 100.00 Very High Very High Very High
adenocard 40 100.00 Very High Very High Very High
antagonist 28 100.00 Very High Very High Very High
qutenza 11 99.84 Very High Very High Very High
Thermal hyperalgesia 1 99.44 Very High Very High Very High
primary afferent fibers 1 98.96 Very High Very High Very High
interstitial cystitis 26 98.82 Very High Very High Very High
Cancer pain 10 98.78 Very High Very High Very High
Spinal cord 34 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 115 100.00 Very High Very High Very High
Ganglion Cysts 38 99.60 Very High Very High Very High
Hyperalgesia 1 99.44 Very High Very High Very High
Nociception 23 99.24 Very High Very High Very High
Nasal Polyps 19 99.24 Very High Very High Very High
Interstitial Cystitis 26 98.82 Very High Very High Very High
Bone Cancer 12 98.68 Very High Very High Very High
Neuropathic Pain 96 96.44 Very High Very High Very High
Frailty 1 95.56 Very High Very High Very High
Ulcers 1 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heteromeric P2X2/3 (P2X2 and P2X3) receptor is expressed in capsaicin-insensitive primary afferent fibers, and its activation leads to the generation of slow desensitizing currents and induction of mechanical allodynia.
Gene_expression (expressed) of P2X2 associated with allodynia, qutenza and primary afferent fibers
1) Confidence 0.75 Published 2000 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 11188502 Disease Relevance 0.45 Pain Relevance 0.76
Here, we tested the hypothesis that adenosine triphosphate is one such key mediator through actions on P2X3 and P2X2/3 receptors, which are expressed selectively on primary afferent nocioceptors, including those innervating the bone.
Gene_expression (expressed) of P2X2 associated with adenocard
2) Confidence 0.75 Published 2010 Journal Brain Section Abstract Doc Link 20802203 Disease Relevance 0.71 Pain Relevance 0.67
Neuronal cell bodies in vagal ganglia express P2X2 and P2X3 receptors [28], and P2X receptors have been identified on afferent nerve processes that innervate airway neuroepithelial bodies [28,29].
Gene_expression (express) of P2X2 in Neuronal
3) Confidence 0.75 Published 2001 Journal Respir Res Section Body Doc Link PMC59581 Disease Relevance 0.25 Pain Relevance 0.10
CONCLUSION: This is the first report of the expression of the P2X(2) receptor in human bladder urothelium.
Gene_expression (expression) of P2X in bladder
4) Confidence 0.73 Published 2004 Journal BJU Int. Section Body Doc Link 15180635 Disease Relevance 0 Pain Relevance 0
P2X and P2X receptor expression in human bladder urothelium and changes in interstitial cystitis.
Gene_expression (expression) of P2X in bladder associated with interstitial cystitis
5) Confidence 0.73 Published 2004 Journal BJU Int. Section Title Doc Link 15180635 Disease Relevance 0.37 Pain Relevance 0.37
Changes in expression of P2X(2) and P2X(3) receptors may contribute to the pain that patients with IC have, and might provide novel drug targets.


Gene_expression (expression) of P2X
6) Confidence 0.73 Published 2004 Journal BJU Int. Section Body Doc Link 15180635 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To investigate whether the expression of P2X(3) receptors (implicated in the pathophysiology of pain) is altered in human bladder urothelium from patients with interstitial cystitis (IC, a major symptom of which is pain), and as P2X(2) receptors can be co-expressed with P2X(3) receptors, to assess their expression also.
Gene_expression (expression) of P2X in bladder associated with pain and interstitial cystitis
7) Confidence 0.73 Published 2004 Journal BJU Int. Section Abstract Doc Link 15180635 Disease Relevance 0.36 Pain Relevance 0.36
P2X and P2X receptor expression in human bladder urothelium and changes in interstitial cystitis.
Gene_expression (expression) of P2X in bladder associated with interstitial cystitis
8) Confidence 0.73 Published 2004 Journal BJU Int. Section Title Doc Link 15180635 Disease Relevance 0.37 Pain Relevance 0.37
There was less gene expression of P2X(3) in IC urothelium, whereas P2X(2) gene expression was unchanged.
Gene_expression (expression) of P2X
9) Confidence 0.73 Published 2004 Journal BJU Int. Section Body Doc Link 15180635 Disease Relevance 0 Pain Relevance 0
Changes in expression of P2X(2) and P2X(3) receptors may contribute to the pain that patients with IC have, and might provide novel drug targets.


Gene_expression (expression) of P2X
10) Confidence 0.73 Published 2004 Journal BJU Int. Section Body Doc Link 15180635 Disease Relevance 0 Pain Relevance 0
Using a well-established rat model of bone cancer pain, AF-353, a recently described potent and selective P2X3 and P2X2/3 receptor antagonist, was administered orally to rats and found to produce highly significant prevention and reversal of bone cancer pain behaviour.
Gene_expression (produce) of P2X2 associated with cancer pain, antagonist and bone cancer
11) Confidence 0.65 Published 2010 Journal Brain Section Abstract Doc Link 20802203 Disease Relevance 0.80 Pain Relevance 0.76
There was greater protein expression of both P2X(2) and P2X(3) in IC bladder urothelium which did not directly correlate with the gene expression.
Gene_expression (expression) of P2X in bladder
12) Confidence 0.64 Published 2004 Journal BJU Int. Section Body Doc Link 15180635 Disease Relevance 0 Pain Relevance 0
There was greater protein expression of both P2X(2) and P2X(3) in IC bladder urothelium which did not directly correlate with the gene expression.
Gene_expression (expression) of P2X in bladder
13) Confidence 0.64 Published 2004 Journal BJU Int. Section Body Doc Link 15180635 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To investigate whether the expression of P2X(3) receptors (implicated in the pathophysiology of pain) is altered in human bladder urothelium from patients with interstitial cystitis (IC, a major symptom of which is pain), and as P2X(2) receptors can be co-expressed with P2X(3) receptors, to assess their expression also.
Gene_expression (co-expressed) of P2X in bladder associated with pain and interstitial cystitis
14) Confidence 0.64 Published 2004 Journal BJU Int. Section Abstract Doc Link 15180635 Disease Relevance 0.37 Pain Relevance 0.37
OBJECTIVE: To investigate whether the expression of P2X(3) receptors (implicated in the pathophysiology of pain) is altered in human bladder urothelium from patients with interstitial cystitis (IC, a major symptom of which is pain), and as P2X(2) receptors can be co-expressed with P2X(3) receptors, to assess their expression also.
Gene_expression (co-expressed) of P2X in bladder associated with pain and interstitial cystitis
15) Confidence 0.64 Published 2004 Journal BJU Int. Section Abstract Doc Link 15180635 Disease Relevance 0.37 Pain Relevance 0.37
It is widely accepted that P2X receptors, especially P2X3 and P2X2/3 selectively expressed in small DRG neurons, play an important role in pain transmission.
Gene_expression (expressed) of P2X2 in neurons associated with ganglion cysts and pain
16) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0.61 Pain Relevance 0.25
P2X(3) is a novel ATP-gated cation channel that is selectively expressed by small-diameter sensory neurones in rodents, and may play a role in nociception by binding ATP released from damaged or inflamed tissues.
Gene_expression (expressed) of P2X associated with nociception
17) Confidence 0.56 Published 2001 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 11576396 Disease Relevance 0.26 Pain Relevance 0.08
One particular receptor, P2X(3), is of particular interest in the context of pain pathways, because it is relatively selectively expressed at high levels by nociceptive sensory neurons.
Gene_expression (expressed) of P2X in sensory neurons associated with nociception and pain
18) Confidence 0.51 Published 2000 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 10869734 Disease Relevance 0.51 Pain Relevance 0.44
RESULTS: P2X(2) was expressed in the human urothelium, in a glycosylated form.
Gene_expression (expressed) of P2X
19) Confidence 0.50 Published 2004 Journal BJU Int. Section Body Doc Link 15180635 Disease Relevance 0 Pain Relevance 0
There was less gene expression of P2X(3) in IC urothelium, whereas P2X(2) gene expression was unchanged.
Gene_expression (expression) of P2X
20) Confidence 0.50 Published 2004 Journal BJU Int. Section Body Doc Link 15180635 Disease Relevance 0 Pain Relevance 0

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