INT8905

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2011
Negated 3
Speculated 9
Reported most in Abstract
Documents 215
Total Number 226
Disease Relevance 157.10
Pain Relevance 34.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EDN1) extracellular region (EDN1) cell-cell signaling (EDN1)
cytoplasm (EDN1)
Anatomy Link Frequency
plasma 23
endothelial cells 14
CSF 7
smooth muscle cells 7
blood 7
EDN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1958 100.00 Very High Very High Very High
cytokine 378 100.00 Very High Very High Very High
Catecholamine 48 100.00 Very High Very High Very High
depression 30 100.00 Very High Very High Very High
qutenza 18 100.00 Very High Very High Very High
calcitonin gene related peptide 1 100.00 Very High Very High Very High
anesthesia 30 99.96 Very High Very High Very High
corticosteroid 40 99.80 Very High Very High Very High
Multiple sclerosis 20 99.80 Very High Very High Very High
Angina 83 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 3713 100.00 Very High Very High Very High
Cancer 1754 100.00 Very High Very High Very High
Metastasis 396 100.00 Very High Very High Very High
Reprotox - General 1 338 100.00 Very High Very High Very High
Myocardial Infarction 274 100.00 Very High Very High Very High
Osteoporosis 237 100.00 Very High Very High Very High
Natriuresis 138 100.00 Very High Very High Very High
Depression 30 100.00 Very High Very High Very High
Endotoxemia 5 100.00 Very High Very High Very High
Ovarian Cancer 683 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to demonstrate the potential role of ET-1 in angina, this paper examines three main factors: (i) that endothelin-1 can cause the pathophysiological states associated with myocardial ischaemia and angina; (ii) that ET-1 is over-expressed in humans and in animal models of myocardial ischaemia, which is associated with angina; and (iii) that modification of the ET-1 system is associated with an improvement in myocardial ischaemia and angina.
Gene_expression (expressed) of ET-1 associated with angina and coronary artery disease
1) Confidence 0.78 Published 2001 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 11811372 Disease Relevance 1.01 Pain Relevance 0.55
Indomethacin treatment produced a small increase in weight (1.4 +/- 0.4 kg; 0.6 to 2.2 kg), a small reduction in renal function (creatinine clearance: 6.8 +/- 1.8 mis/min; 3.3 to 10.3 mis/min) but a significant (83%) increase in daily urinary endothelin-1 production (13.1 +/- 3.4 ng/ml; 6.4 to 19.8 ng/ml) without altering plasma ET-1 concentration, suggesting increased renal synthesis.
Gene_expression (production) of endothelin-1 in plasma associated with disorders of creatine metabolism
2) Confidence 0.78 Published 1996 Journal J Hum Hypertens Section Abstract Doc Link 8736458 Disease Relevance 0.41 Pain Relevance 0.24
We show here that plasma immunoreactive endothelin concentrations are significantly elevated in men with metastatic prostate cancer and that every human prostate cancer cell line tested produces endothelin-1 messenger RNA and secretes immunoreactive endothelin.
Gene_expression (produces) of endothelin-1 messenger RNA in plasma associated with prostate cancer
3) Confidence 0.78 Published 1995 Journal Nat. Med. Section Abstract Doc Link 7585222 Disease Relevance 0.87 Pain Relevance 0.09
Effects of phosphoramidon on endothelin-1 and big endothelin-1 production in human aortic endothelial cells.
Gene_expression (production) of endothelin-1 in endothelial cells associated with analgesic
4) Confidence 0.77 Published 1995 Journal Biol. Pharm. Bull. Section Title Doc Link 7550091 Disease Relevance 0 Pain Relevance 0.10
Thus, ET-1 generation from exogenously applied big ET-1 reflects the functional phosphoramidon-sensitive ECE activities in human aortic endothelial cells.
Gene_expression (generation) of ET-1 in endothelial cells
5) Confidence 0.77 Published 1995 Journal Biol. Pharm. Bull. Section Abstract Doc Link 7550091 Disease Relevance 0 Pain Relevance 0
Effects of phosphoramidon on endothelin-1 and big endothelin-1 production in human aortic endothelial cells.
Gene_expression (production) of endothelin-1 in endothelial cells associated with analgesic
6) Confidence 0.77 Published 1995 Journal Biol. Pharm. Bull. Section Title Doc Link 7550091 Disease Relevance 0 Pain Relevance 0.10
METHODS: Cultured human umbilical vein endothelial cells were exposed to cyclic strain in the presence of propofol, and ET-1 expression was examined by Northern blotting and enzyme-linked immunosorbent assay kit.
Gene_expression (expression) of ET-1 in endothelial cells
7) Confidence 0.75 Published 2009 Journal Anesthesiology Section Body Doc Link 19104173 Disease Relevance 0 Pain Relevance 0
Effects of propofol on cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells.
Gene_expression (expression) of endothelin-1 in umbilical vein associated with sprains and strains
8) Confidence 0.75 Published 2009 Journal Anesthesiology Section Title Doc Link 19104173 Disease Relevance 0.28 Pain Relevance 0.10
RESULTS: The authors show that propofol inhibits strain-induced ET-1 expression, strain-increased reactive oxygen species formation, and extracellular signal-regulated protein kinase phosphorylation.
Gene_expression (expression) of ET-1
9) Confidence 0.75 Published 2009 Journal Anesthesiology Section Body Doc Link 19104173 Disease Relevance 0 Pain Relevance 0
The endothelin-B (ETB) receptor is expressed in primary and metastatic malignant melanoma, and increased expression of ETB correlates with tumor progression in malignant melanoma [15].
Gene_expression (expressed) of endothelin associated with cancer and skin cancer
10) Confidence 0.75 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2856553 Disease Relevance 0.85 Pain Relevance 0.04
Plasma levels of atrial natriuretic peptide (ANP), endothelin, vasopressin, and catecholamines were measured before, during, and after cardiopulmonary bypass (CPB) until the first postoperative day.
Gene_expression (levels) of endothelin in Plasma associated with natriuresis and catecholamine
11) Confidence 0.75 Published 1994 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 7520297 Disease Relevance 0.10 Pain Relevance 0.15
A locally increased endothelin production in coronary artery disease or other atherosclerotic diseases may increase circulating endothelin plasma concentrations before symptoms of disease are manifest.
Gene_expression (production) of endothelin in plasma associated with coronary artery disease, atherosclerosis and disease
12) Confidence 0.75 Published 1993 Journal Res Exp Med (Berl) Section Abstract Doc Link 8235075 Disease Relevance 0.98 Pain Relevance 0
Several recent studies have shifted the focus from solely examining ET-1 expression to investigating the role of ETA and ETB receptors in ocular blood flow.
Spec (examining) Gene_expression (expression) of ET-1 in blood
13) Confidence 0.74 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 0.74 Pain Relevance 0
It has been determined that ET-1 provokes forceful contractions of isolated ophthalmic arteries with smaller vessels expressing greater ET-1 sensitivity (Haefliger et al 1992; Polak et al 2003).
Gene_expression (expressing) of ET-1 in vessels
14) Confidence 0.74 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 1.10 Pain Relevance 0
Ocular tissues, eg, vascular and extravascular sites in the retina are a rich source of ET-1 expression, and ET-1 contributes to abnormal retinal hemodynamics in diabetic retinopathy (Kohner et al 1995; Pang et al 1997).
Gene_expression (expression) of ET-1 in retina associated with diabetic retinopathy
15) Confidence 0.74 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605330 Disease Relevance 1.58 Pain Relevance 0.18
Endothelin (ET)-1 is synthesized in human amnion and immunoreactive (ir) ET is present in amniotic fluid in concentrations 10- to 100-times those found in plasma.
Gene_expression (synthesized) of Endothelin in amniotic fluid
16) Confidence 0.74 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8501173 Disease Relevance 0.08 Pain Relevance 0.08
Here we show that in a murine osteolytic 2472 sarcoma model of bone cancer pain, the 2472 sarcoma cells express high levels of ET-1, but express low or undetectable levels of endothelin A (ETAR) or B (ETBR) receptors whereas a subpopulation of sensory neurons express the ETAR and non-myelinating Schwann cells express the ETBR.
Gene_expression (express) of ET-1 in sensory neurons associated with sarcoma and cancer pain
17) Confidence 0.73 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207337 Disease Relevance 1.17 Pain Relevance 0.60
As tumor expression and release of ET-1 has been shown to be regulated by the local environment, location specific expression and release of ET-1 by tumor cells may provide insight into the mechanisms that underlie the heterogeneity of bone cancer pain that is frequently observed in humans with multiple skeletal metastases.
Gene_expression (expression) of ET-1 associated with cancer pain, cancer and metastasis
18) Confidence 0.73 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207337 Disease Relevance 1.23 Pain Relevance 0.73
Moreover, during 24 hours incubation we have investigated the production of endothelin 1 (ET-1), E-selectin and Interleukin 8 (IL-8) and it appears that ozonation enhances IL-8, inhibits E-selectin and hardly modifies ET-1 production.
Spec (investigated) Gene_expression (production) of ET-1
19) Confidence 0.73 Published 2000 Journal Mediators Inflamm Section Abstract Doc Link PMC1781775 Disease Relevance 0.23 Pain Relevance 0.18
Moreover, during 24 hours incubation we have investigated the production of endothelin 1 (ET-1), E-selectin and Interleukin 8 (IL-8) and it appears that ozonation enhances IL-8, inhibits E-selectin and hardly modifies ET-1 production.
Gene_expression (production) of ET-1
20) Confidence 0.73 Published 2000 Journal Mediators Inflamm Section Abstract Doc Link PMC1781775 Disease Relevance 0.10 Pain Relevance 0.08

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