INT89052

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 2.92
Pain Relevance 7.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)
Anatomy Link Frequency
neurons 6
visceral 4
spinal nerve 2
cardiomyocytes 2
sciatic nerve 2
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 85 100.00 Very High Very High Very High
Kinase C 41 99.88 Very High Very High Very High
Peripheral nerve injury 1 99.80 Very High Very High Very High
Spinal nerve ligature 2 98.88 Very High Very High Very High
Visceral pain 104 98.80 Very High Very High Very High
Lasting pain 1 98.44 Very High Very High Very High
projection neuron 4 98.20 Very High Very High Very High
Neuropathic pain 9 97.68 Very High Very High Very High
spinal dorsal horn 14 96.76 Very High Very High Very High
Pain 145 96.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 1 99.80 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

108 98.80 Very High Very High Very High
Pain 138 98.44 Very High Very High Very High
Neuropathic Pain 16 97.68 Very High Very High Very High
Ganglion Cysts 3 92.72 High High
Arthritis 69 91.40 High High
Hyperalgesia 4 75.00 Quite High
Nociception 142 72.04 Quite High
Targeted Disruption 13 70.96 Quite High
Hypertrophic Cardiomyopathy 3 52.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The heat transducer VR-1 is therefore suggested as the molecular target of PKA phosphorylation, and potentiation of current responses to heat depends on phosphorylation at predicted PKA consensus sites.
Positive_regulation (depends) of Phosphorylation (phosphorylation) of PKA
1) Confidence 0.37 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12040081 Disease Relevance 0.14 Pain Relevance 0.21
NMDA receptor phosphorylation by PKA or PKC also accelerates the rise and decay times of the ion channel [69,78], which explains the absence of apparent differences in the kinetics of NMDA EPSC and compound EPSC in the present study.
Positive_regulation (accelerates) of Phosphorylation (phosphorylation) of PKA associated with nmda receptor
2) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.32 Pain Relevance 0.60
In contrast with isoproterenol, ethanol exposure did not increase cAMP accumulation, PKA activity, or the phosphorylated form of CREB.
Neg (not) Positive_regulation (increase) of Phosphorylation (phosphorylated) of PKA
3) Confidence 0.21 Published 2000 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 10923996 Disease Relevance 0 Pain Relevance 0
We employed inhibitors and activators of protein kinase A (PKA), protein kinase C (PKC), extracellular signal-regulated kinase 1 and 2 (ERK1/2) and calcium/calmodulin-dependent kinase II (CaMKII) to examine whether these kinases individually or in concert mediate the increase in CREB phosphorylation that is evident as early as 2 h after loose ligation of the sciatic nerve.
Positive_regulation (employed) of Phosphorylation (inhibitors) of PKA in sciatic nerve associated with kinase c and sciatic nerve
4) Confidence 0.18 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15882794 Disease Relevance 0.20 Pain Relevance 0.38
Their results at submaximal activation indicate that ablation of murine cardiac cMyBP-C and PKA phosphorylation of cMyBP-C both accelerate the rate of force generation.
Positive_regulation (accelerate) of Phosphorylation (phosphorylation) of PKA
5) Confidence 0.15 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0.07 Pain Relevance 0.08
Accordingly, the PKA-mediated phosphorylation of cMyBP-C might contribute to the increased cardiac output in response to ?
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of PKA
6) Confidence 0.14 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0.12 Pain Relevance 0
To assess the time course and magnitude of PKA-induced phosphorylation of cMyBP-C and cTnI, suspensions of cardiomyocytes from a sample of the Quiescence group, where phosphorylation was low, were incubated with recombinant PKA as described in the Methods.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of PKA-induced in cardiomyocytes
7) Confidence 0.14 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0
NMDA receptor phosphorylation by PKA or PKC also accelerates the rise and decay times of the ion channel [67,68], which would explain the absence of apparent differences in kinetics in the present study [for discussion see [34]].
Positive_regulation (accelerates) of Phosphorylation (phosphorylation) of PKA associated with nmda receptor
8) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 0.14 Pain Relevance 0.77
Increased phosphorylation of CREB through the activated PKA was involved in CGRP-induced NK1 receptor gene expression in spinal neurons [46].
Positive_regulation (activated) of Phosphorylation (phosphorylation) of PKA in neurons
9) Confidence 0.12 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.19 Pain Relevance 0.87
Additionally, it has been demonstrated that sex steroid hormones, such as estrogen, increased the activity of spinal NMDA receptors via PKA-mediated phosphorylation of NR1 subunits in an animal visceral pain model [44].
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of PKA in visceral associated with visceral pain and nmda receptor
10) Confidence 0.12 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.07 Pain Relevance 0.88
Increased phosphorylation of CREB through the activated PKA was involved in CGRP-induced NK1 receptor gene expression in spinal neurons [46].
Positive_regulation (Increased) of Phosphorylation (phosphorylation) of PKA in neurons
11) Confidence 0.12 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.19 Pain Relevance 0.87
Additionally, it has been demonstrated that sex steroid hormones, such as estrogen, increased the activity of spinal NMDA receptors via PKA-mediated phosphorylation of NR1 subunits in an animal visceral pain model [44].
Positive_regulation (increased) of Phosphorylation (phosphorylation) of PKA in visceral associated with visceral pain and nmda receptor
12) Confidence 0.12 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.07 Pain Relevance 0.95
The data suggest that PKA mediated NMDA receptor phosphorylation plays an important role in spinal nerve ligation induced neuropathic pain.
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of PKA in spinal nerve associated with spinal nerve ligature, nmda receptor and neuropathic pain
13) Confidence 0.11 Published 2005 Journal Pain Section Abstract Doc Link 15936881 Disease Relevance 0.64 Pain Relevance 0.93
Our results raise two possibilities. (1) Direct phosphorylation of VR1 by PKA may not be responsible for the sensitization; instead, phosphorylation of regulatory proteins associated with VR1 would account for the sensitization of I(CAP) evoked by prostaglandin E(2) in dorsal root ganglion (DRG) neurons. (2) DRG neurons may have a different PKA signaling mechanism that is not replicable in Xenopus oocytes or Aplysia R2 neurons.
Neg (not) Spec (may) Positive_regulation (responsible) of Phosphorylation (phosphorylation) of PKA in neurons associated with ganglion cysts and dorsal root ganglion
14) Confidence 0.09 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10869815 Disease Relevance 0.35 Pain Relevance 0.51

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