INT89053

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Context Info
Confidence 0.70
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 8.89
Pain Relevance 9.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 8
afferent neurons 2
ovary 2
Trpv1 (Rattus norvegicus)
Trpv1 - S800A (2)
Pain Link Frequency Relevance Heat
Kinase C 81 100.00 Very High Very High Very High
agonist 42 99.96 Very High Very High Very High
qutenza 249 99.44 Very High Very High Very High
dorsal root ganglion 164 99.08 Very High Very High Very High
Inflammation 18 98.00 Very High Very High Very High
substance P 11 94.76 High High
Lasting pain 7 92.04 High High
Cannabinoid 7 90.16 High High
Neuropathic pain 13 88.92 High High
diabetic neuropathy 4 88.80 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 22 99.72 Very High Very High Very High
Ganglion Cysts 172 99.08 Very High Very High Very High
INFLAMMATION 22 98.00 Very High Very High Very High
Herpes Simplex Virus 1 97.16 Very High Very High Very High
Hypoxia 4 93.04 High High
Hypersensitivity 10 92.44 High High
Hyperglycemia 2 92.08 High High
Pain 46 92.04 High High
Syndrome 2 89.32 High High
Neuropathic Pain 39 88.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased phosphorylation levels of VR1 were also observed in DRG neurons from diabetic rats.
Positive_regulation (levels) of Phosphorylation (phosphorylation) of VR1 in neurons associated with dorsal root ganglion and diabetes mellitus
1) Confidence 0.70 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15513920 Disease Relevance 1.75 Pain Relevance 1.27
Increased phosphorylation levels of VR1 were also observed in DRG neurons from diabetic rats.
Positive_regulation (Increased) of Phosphorylation (phosphorylation) of VR1 in neurons associated with dorsal root ganglion and diabetes mellitus
2) Confidence 0.70 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15513920 Disease Relevance 1.75 Pain Relevance 1.27
The acute effects of oxaliplatin observed in this study may have been brought about by activation of adenylyl cyclase and a consequent increase in cAMP leading to TRPV1 phosphorylation and sensitization.
Positive_regulation (leading) of Phosphorylation (phosphorylation) of TRPV1
3) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC3003244 Disease Relevance 0.25 Pain Relevance 0.34
Furthermore, protein kinase C-dependent phosphorylation of Ser800 in the TRPV1 C terminus potentiated agonist-evoked ionic selectivity changes.
Positive_regulation (potentiated) of Phosphorylation (phosphorylation) of TRPV1 associated with kinase c and agonist
4) Confidence 0.50 Published 2008 Journal Nat. Neurosci. Section Abstract Doc Link 18391945 Disease Relevance 0 Pain Relevance 0.43
At this concentration, chelerythrine effectively blocked the tachyphylaxis of TRPV1 upon repetitive stimulation [see Additional file 1], which is known to be caused by PKC phosphorylation of TRPV1 [27].
Positive_regulation (caused) of Phosphorylation (phosphorylation) of TRPV1 associated with kinase c
5) Confidence 0.50 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.08 Pain Relevance 0.26
The potentiation seems to be caused by phosphorylation of the serine residues of TRPV1 by PKC.
Positive_regulation (caused) of Phosphorylation (phosphorylation) of TRPV1
6) Confidence 0.49 Published 2010 Journal Yakugaku Zasshi Section Abstract Doc Link 20190512 Disease Relevance 1.18 Pain Relevance 0.57
The potentiation seems to be caused by phosphorylation of the serine residues of TRPV1 by PKC.
Positive_regulation (residues) of Phosphorylation (phosphorylation) of TRPV1
7) Confidence 0.49 Published 2010 Journal Yakugaku Zasshi Section Abstract Doc Link 20190512 Disease Relevance 1.18 Pain Relevance 0.57
to the cell membrane triggers TRPV1 phosphorylation and sensitization [24].
Positive_regulation (triggers) of Phosphorylation (phosphorylation) of TRPV1
8) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 0.42 Pain Relevance 0.65
We also confirm the importance of TRPA1 in WIN-induced dephosphorylation of TRPV1 in Chinese hamster ovary cells through targeted expression of one or both receptor channels.
Positive_regulation (importance) of Phosphorylation (dephosphorylation) of TRPV1 in ovary
9) Confidence 0.47 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16954222 Disease Relevance 0.32 Pain Relevance 0.51
Here, we employ a highly defective herpes simplex virus vector (vHDNP) that expresses dominant negative PKCepsilon (DNPKCepsilon) as a strategy to demonstrate that PKCepsilon is essential for: (i) maintenance of basal phosphorylation and normal TRPV1 responses to capsaicin (CAPS), a TRPV1 agonist and (ii) enhancement of TRPV1 responses by phorbol esters.
Positive_regulation (maintenance) of Phosphorylation (phosphorylation) of TRPV1 associated with qutenza, herpes simplex virus and agonist
10) Confidence 0.47 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18973552 Disease Relevance 0.42 Pain Relevance 0.88
Immunofluorescence and western blot analysis showed a significant decrease in CB1 and a reciprocal increase in TRPV1 expression and phosphorylation in DRG neurons from stressed rats.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of TRPV1 in neurons
11) Confidence 0.46 Published 2009 Journal Gut Section Body Doc Link 18936104 Disease Relevance 0.13 Pain Relevance 0
These data suggest that activation of NK2 receptors in afferent neurons leads to PKC-induced phosphorylation of TRPV1, resulting in sensitization of CAPS-evoked currents and slower desensitization.
Positive_regulation (leads) of Phosphorylation (phosphorylation) of TRPV1 in afferent neurons
12) Confidence 0.46 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18598261 Disease Relevance 0 Pain Relevance 0.39
A short-term (10min) exposure to GR73632 resulted in an increase in the TRPV1 phosphorylation.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of TRPV1
13) Confidence 0.46 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18809416 Disease Relevance 0.07 Pain Relevance 1.02
To investigate the role of PKC-mediated phosphorylation of TRPV1, a plasmid was generated, which encodes a mutant TRPV1 in which serine 800 is replaced by alanine (TRPV1-S800A).
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of TRPV1
14) Confidence 0.40 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0.33 Pain Relevance 0.25
To investigate the role of PKC-mediated phosphorylation of TRPV1, a plasmid was generated, which encodes a mutant TRPV1 in which serine 800 is replaced by alanine (TRPV1-S800A).
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of TRPV1-S800A (S800A, S800A)
15) Confidence 0.40 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0.33 Pain Relevance 0.25
To investigate the role of PKC-mediated phosphorylation of TRPV1, a plasmid was generated, which encodes a mutant TRPV1 in which serine 800 is replaced by alanine (TRPV1-S800A).
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of TRPV1
16) Confidence 0.40 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0.33 Pain Relevance 0.25
Our results raise two possibilities. (1) Direct phosphorylation of VR1 by PKA may not be responsible for the sensitization; instead, phosphorylation of regulatory proteins associated with VR1 would account for the sensitization of I(CAP) evoked by prostaglandin E(2) in dorsal root ganglion (DRG) neurons. (2) DRG neurons may have a different PKA signaling mechanism that is not replicable in Xenopus oocytes or Aplysia R2 neurons.
Neg (not) Spec (may) Positive_regulation (responsible) of Phosphorylation (phosphorylation) of VR1 in neurons associated with ganglion cysts and dorsal root ganglion
17) Confidence 0.35 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10869815 Disease Relevance 0.35 Pain Relevance 0.51

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